O18413
Gene name |
Rpt6 (DUG, Pros45, Ug, CG1489) |
Protein name |
26S proteasome regulatory subunit 8 |
Names |
|
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG1489 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O18413
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O18413-F1 | Predicted | AlphaFoldDB |
No variants for O18413
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O18413 | |||||
No associated diseases with O18413
5 regional properties for O18413
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | AAA+ ATPase domain | 181 - 320 | IPR003593 |
| domain | ATPase, AAA-type, core | 185 - 317 | IPR003959 |
| conserved_site | ATPase, AAA-type, conserved site | 288 - 306 | IPR003960 |
| domain | Proteasomal ATPase OB C-terminal domain | 72 - 127 | IPR032501 |
| domain | AAA ATPase, AAA+ lid domain | 341 - 383 | IPR041569 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| proteasome regulatory particle | A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex. |
| proteasome regulatory particle, base subcomplex | The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| proteasome-activating activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| proteasome-mediated ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q01939 | RPT6 | 26S proteasome regulatory subunit 8 homolog | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P62194 | PSMC5 | 26S proteasome regulatory subunit 8 | Bos taurus (Bovine) | PR |
| P62195 | PSMC5 | 26S proteasome regulatory subunit 8 | Homo sapiens (Human) | PR |
| P62196 | Psmc5 | 26S proteasome regulatory subunit 8 | Mus musculus (Mouse) | PR |
| P62197 | PSMC5 | 26S proteasome regulatory subunit 8 | Sus scrofa (Pig) | PR |
| P62198 | Psmc5 | 26S proteasome regulatory subunit 8 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTVTNRMEIE | SAYHKGEGFR | SYYIQKIEEL | QLVVAEKHQN | LRRLQAQRNE | LNAKVRMLRE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ELQLLQEQGS | YVGEVVKPMD | KKKVLVKVHP | EGKFVVDLDK | NIDINDVTPN | CRVALRNESY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TLHKILPNKV | DPLVSLMMVE | KVPDSTYEMV | GGLDKQIKEI | KEVIELPVKH | PELFDALGIA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QPKGVLLYGP | PGTGKTLLAR | AVAHHTECTF | IRVSGSELVQ | KFIGEGSRMV | RELFVMAREH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| APSIIFMDEI | DSIGSSRIES | GSGGDSEVQR | TMLELLNQLD | GFEATKNIKV | IMATNRIDIL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DPALLRPGRI | DRKIEFPPPN | EEARLDILKI | HSRKMNLTRG | INLRKIAELM | PGASGAEVKG |
| 370 | 380 | 390 | 400 | ||
| VCTEAGMYAL | RERRVHVTQE | DFEMAVAKVM | QKDSEKNMSI | KKLWK |