Q5E9F9

PR
Gene name
PSMC2
Protein name
26S proteasome regulatory subunit 7
Names
26S proteasome AAA-ATPase subunit RPT1, Proteasome 26S subunit ATPase 2
Species
Bos taurus (Bovine)
KEGG Pathway
bta:530186
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-228 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5E9F9

Entry ID Method Resolution Chain Position Source
AF-Q5E9F9-F1 Predicted AlphaFoldDB

21 variants for Q5E9F9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs477892633 37 G>C No EVA
rs466599553 45 I>L No EVA
rs433669018 45 I>S No EVA
rs448956455 50 D>V No EVA
rs467404942 54 Q>H No EVA
rs445659126 57 K>* No EVA
rs437852793 62 L>H No EVA
rs456407319 63 T>A No EVA
rs468529255 119 A>V No EVA
rs460752009 158 D>N No EVA
rs798509747 181 K>R No EVA
rs449017996 187 L>H No EVA
rs478641939 187 L>V No EVA
rs467608080 190 V>E No EVA
rs448602448 199 E>* No EVA
rs438445049 287 D>Y No EVA
rs436876171 326 T>P No EVA
rs447113865 336 R>G No EVA
rs462423100 386 R>T No EVA
rs441939909 416 V>G No EVA
rs463756144 430 M>T No EVA

No associated diseases with Q5E9F9

4 regional properties for Q5E9F9

Type Name Position InterPro Accession
domain AAA+ ATPase domain 208 - 347 IPR003593
domain ATPase, AAA-type, core 212 - 344 IPR003959
conserved_site ATPase, AAA-type, conserved site 315 - 333 IPR003960
domain AAA ATPase, AAA+ lid domain 367 - 411 IPR041569

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Colocalizes with TRIM5 in cytoplasmic bodies
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
organelle membrane A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.
P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
proteasome accessory complex A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex.
proteasome complex A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
proteasome regulatory particle, base subcomplex The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
proteasome-activating activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.

2 GO annotations of biological process

Name Definition
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P33299 RPT1 26S proteasome regulatory subunit 7 homolog Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P62194 PSMC5 26S proteasome regulatory subunit 8 Bos taurus (Bovine) PR
P35998 PSMC2 26S proteasome regulatory subunit 7 Homo sapiens (Human) PR
P46471 Psmc2 26S proteasome regulatory subunit 7 Mus musculus (Mouse) PR
Q63347 Psmc2 26S proteasome regulatory subunit 7 Rattus norvegicus (Rat) PR
Q0WQM8 At1g53790 F-box protein At1g53790 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MPDYLGADQR KTKEDEKDDK PIRALDEGDI ALLKTYGQST YSRQIKQVED DIQQLLKKIN
70 80 90 100 110 120
ELTGIKESDT GLAPPALWDL AADKQTLQSE QPLQVARCTK IINADSEDPK YIINVKQFAK
130 140 150 160 170 180
FVVDLSDQVA PTDIEEGMRV GVDRNKYQIH IPLPPKIDPT VTMMQVEEKP DVTYSDVGGC
190 200 210 220 230 240
KEQIEKLREV VETPLLHPER FVNLGIEPPK GVLLFGPPGT GKTLCARAVA NRTDACFIRV
250 260 270 280 290 300
IGSELVQKYV GEGARMVREL FEMARTKKAC LIFFDEIDAI GGARFDDGAG GDNEVQRTML
310 320 330 340 350 360
ELINQLDGFD PRGNIKVLMA TNRPDTLDPA LMRPGRLDRK IEFSLPDLEG RTHIFKIHAR
370 380 390 400 410 420
SMSVERDIRF ELLARLCPNS TGAEIRSVCT EAGMFAIRAR RKIATEKDFL EAVNKVIKSY
430
AKFSATPRYM TYN