AiPD: Autoinhibited Protein Database

P35998

Gene name	PSMC2 (MSS1)
Protein name	26S proteasome regulatory subunit 7
Names	26S proteasome AAA-ATPase subunit RPT1, Proteasome 26S subunit ATPase 2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5701
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-228 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-228 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

60 structures for P35998

Entry ID	Method	Resolution	Chain	Position	Source
5GJQ	EM	450 A	H	1-433	PDB
5GJR	EM	350 A	H/v	1-433	PDB
5L4G	EM	402 A	H	1-433	PDB
5LN3	EM	680 A	H	1-433	PDB
5M32	EM	380 A	c	1-433	PDB
5T0C	EM	380 A	AA/BA	1-433	PDB
5T0G	EM	440 A	A	1-433	PDB
5T0H	EM	680 A	A	1-433	PDB
5T0I	EM	800 A	A	1-433	PDB
5T0J	EM	800 A	A	1-433	PDB
5VFP	EM	420 A	A	35-433	PDB
5VFQ	EM	420 A	A	35-433	PDB
5VFR	EM	490 A	A	35-433	PDB
5VFS	EM	360 A	A	1-433	PDB
5VFT	EM	700 A	A	73-433	PDB
5VFU	EM	580 A	A	73-433	PDB
5VGZ	EM	370 A	A	73-155	PDB
5VHF	EM	570 A	A	73-424	PDB
5VHH	EM	610 A	A	73-424	PDB
5VHI	EM	680 A	A	73-424	PDB
5VHJ	EM	850 A	A	180-424	PDB
5VHM	EM	830 A	A	159-424	PDB
5VHN	EM	730 A	A	159-424	PDB
5VHO	EM	830 A	A	158-424	PDB
5VHP	EM	790 A	A	159-424	PDB
5VHQ	EM	890 A	A	159-424	PDB
5VHR	EM	770 A	A	159-424	PDB
5VHS	EM	880 A	A	73-424	PDB
6MSB	EM	300 A	A	1-433	PDB
6MSD	EM	320 A	A	1-433	PDB
6MSE	EM	330 A	M/m	94-136	PDB
6MSG	EM	350 A	A	1-433	PDB
6MSH	EM	360 A	A	1-433	PDB
6MSJ	EM	330 A	A	1-433	PDB
6MSK	EM	320 A	A	1-433	PDB
6WJD	EM	480 A	A	1-433	PDB
6WJN	EM	570 A	A	35-433	PDB
7QXN	EM	370 A	A	1-433	PDB
7QXP	EM	360 A	A	1-433	PDB
7QXU	EM	430 A	A	1-433	PDB
7QXW	EM	410 A	A	1-433	PDB
7QXX	EM	440 A	A	1-433	PDB
7QY7	EM	470 A	A	1-433	PDB
7QYA	EM	480 A	A	1-433	PDB
7QYB	EM	410 A	A	1-433	PDB
7W37	EM	300 A	A	1-433	PDB
7W38	EM	310 A	A	1-433	PDB
7W39	EM	320 A	A	1-433	PDB
7W3A	EM	350 A	A	1-433	PDB
7W3B	EM	360 A	A	1-433	PDB
7W3C	EM	340 A	A	1-433	PDB
7W3F	EM	330 A	A	1-433	PDB
7W3G	EM	320 A	A	1-433	PDB
7W3H	EM	320 A	A	1-433	PDB
7W3I	EM	350 A	A	1-433	PDB
7W3J	EM	350 A	A	1-433	PDB
7W3K	EM	360 A	A	1-433	PDB
7W3M	EM	350 A	A	1-433	PDB
8CVT	EM	300 A	A	1-433	PDB
AF-P35998-F1	Predicted				AlphaFoldDB

162 variants for P35998

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1464465948 CA368761530	2	P>L		No	ClinGen gnomAD
CA4418897 rs751112880	2	P>S		No	ClinGen ExAC TOPMed gnomAD
CA368761540 rs1255101451	3	D>A		No	ClinGen gnomAD
rs754678714 CA4418898	3	D>H		No	ClinGen ExAC TOPMed gnomAD
CA368761535 rs754678714	3	D>N		No	ClinGen ExAC TOPMed gnomAD
CA4418900 rs202147098	5	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs61738529 CA163916491	6	G>S		No	ClinGen Ensembl
rs554292187 CA4418902	7	A>S	Variant assessed as Somatic; 0.0006468 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs554292187 CA368761602	7	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1206757733 CA368761619	8	D>Y		No	ClinGen TOPMed gnomAD
CA4418904 rs772261210	9	Q>K		No	ClinGen ExAC
rs780482695 CA4418905	10	R>G		No	ClinGen ExAC gnomAD
rs981661558 CA163916566	10	R>L		No	ClinGen TOPMed
rs768955364 CA4418907	11	K>N		No	ClinGen ExAC gnomAD
CA4418906 rs747152993	11	K>R		No	ClinGen ExAC gnomAD
rs558519530 CA4418908	12	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201035586 CA163916598	13	K>E		No	ClinGen 1000Genomes
rs1230656057 CA368761731	14	E>A		No	ClinGen gnomAD
rs1365849062 CA368761728	14	E>Q		No	ClinGen gnomAD
rs1329129617 CA368761779	16	E>D		No	ClinGen TOPMed gnomAD
rs943377031 CA163916606	16	E>G		No	ClinGen TOPMed
rs773066092 CA4418911	17	K>T		No	ClinGen ExAC gnomAD
rs751398461 CA4418914	18	D>E		No	ClinGen ExAC TOPMed gnomAD
rs761947375 CA4418913	18	D>N		No	ClinGen ExAC gnomAD
rs767172349 CA4418916	19	D>A		No	ClinGen ExAC gnomAD
rs759287626 CA4418915	19	D>Y		No	ClinGen ExAC gnomAD
CA368761852 rs1184109527	20	K>R		No	ClinGen gnomAD
CA368761863 rs1472260592	21	P>T		No	ClinGen gnomAD
CA368736056 rs1462921430	27	E>D		No	ClinGen TOPMed
rs776196601 CA4418957	31	A>V		No	ClinGen ExAC gnomAD
CA4418959 rs145606402	32	L>F		No	ClinGen ESP ExAC gnomAD
CA4418958 rs761373728	32	L>V		No	ClinGen ExAC TOPMed gnomAD
CA163852538 rs918541706	35	T>S		No	ClinGen TOPMed
CA4418979 rs779920178	38	Q>E		No	ClinGen ExAC gnomAD
CA4418980 rs753258999	39	S>N		No	ClinGen ExAC gnomAD
CA163853285 rs886803788	40	T>A		No	ClinGen gnomAD
CA368736230 rs376614496	40	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA368736226 rs886803788	40	T>S		No	ClinGen gnomAD
rs376614496 CA4418981	40	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1390320032 CA368736300	45	I>N		No	ClinGen gnomAD
CA163853301 rs11545648	46	K>M		No	ClinGen Ensembl
TCGA novel	46	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4418983 CA163853315 rs369823547	47	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1301108328 CA368736338	48	V>I		No	ClinGen gnomAD
rs1352254476 CA368736416	52	I>F		No	ClinGen TOPMed gnomAD
TCGA novel	53	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757447647 CA4418984	53	Q>R		No	ClinGen ExAC gnomAD
TCGA novel	67	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA163853886 rs878927065	71	G>R		No	ClinGen Ensembl
rs758549858 CA4419005	71	G>V		No	ClinGen ExAC gnomAD
CA368737020 rs1484550739	74	P>L		No	ClinGen gnomAD
rs1563486194 CA368737014	74	P>S		No	ClinGen Ensembl
rs751491617 CA4419007	75	P>A		No	ClinGen ExAC gnomAD
rs781229277 CA4419009	79	D>H		No	ClinGen ExAC gnomAD
CA368737100 rs1190707141	79	D>V		No	ClinGen gnomAD
rs1335507977 CA368737238	86	T>I		No	ClinGen TOPMed
rs74998067 CA163853917	90	E>D		No	ClinGen gnomAD
TCGA novel	100	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4419026 rs767340599	100	K>R		No	ClinGen ExAC gnomAD
rs975171821 CA163859514	101	I>V		No	ClinGen Ensembl
rs765537959 CA4419027	103	N>S		No	ClinGen ExAC TOPMed gnomAD
CA163859544 rs200658637	105	D>N		No	ClinGen 1000Genomes gnomAD
rs200658637 CA368739979	105	D>Y		No	ClinGen 1000Genomes gnomAD
CA4419028 rs755796502	106	S>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	114	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA163859590 rs201653763	116	K>N		No	ClinGen 1000Genomes
CA163859596 rs200242883	121	F>L		No	ClinGen 1000Genomes
rs11545647 CA163859604	123	V>A		No	ClinGen Ensembl
CA368740369 rs1446512014	128	Q>H		No	ClinGen TOPMed gnomAD
CA368740517 rs1248705494	134	I>M		No	ClinGen gnomAD
rs745351399 CA4419033	138	M>I		No	ClinGen ExAC TOPMed gnomAD
CA368740567 rs1191610561	138	M>K		No	ClinGen gnomAD
rs771671019 CA4419034	139	R>G		No	ClinGen ExAC gnomAD
rs770391778	141	G>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	143	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4419060 rs771485377	149	I>V		No	ClinGen ExAC gnomAD
rs1444793640 CA368740822	151	I>M		No	ClinGen TOPMed
CA368740848 rs1245452605	154	P>H		No	ClinGen gnomAD
CA368740870 rs1356678980	155	P>L		No	ClinGen gnomAD
rs1289874307 CA368740858	155	P>S		No	ClinGen gnomAD
CA163860256 rs775120634	156	K>R		No	ClinGen TOPMed
TCGA novel	159	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1463144110 CA368740952	160	T>I		No	ClinGen TOPMed gnomAD
TCGA novel	170	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs969789113 CA163861038	178	G>D		No	ClinGen Ensembl
CA4419095 rs775626147	181	K>N		No	ClinGen ExAC gnomAD
CA4419096 rs760735336	188	R>Q		No	ClinGen ExAC TOPMed
rs1470605759 CA368742497	191	V>A		No	ClinGen TOPMed
rs768795269 CA4419097	193	T>I		No	ClinGen ExAC
CA368742580 rs1365791970	196	L>P		No	ClinGen TOPMed
CA368742595 rs1174791601	197	H>L		No	ClinGen gnomAD
CA4419111 rs374959956	200	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1174917757 CA368742720	200	R>S		No	ClinGen TOPMed gnomAD
TCGA novel	201	F>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs199759890 CA163861840	206	I>F		No	ClinGen Ensembl
CA368742766 rs1358239751	207	E>G		No	ClinGen TOPMed
CA368742799 rs1383127080	212	V>A		No	ClinGen gnomAD
rs1158172908 CA368742795	212	V>M		No	ClinGen TOPMed gnomAD
rs776715911 CA4419115	221	G>A		No	ClinGen ExAC gnomAD
CA368742886 rs1239171805	226	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA4419121 rs774084514	232	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
RCV001280764 rs1820573027	251	G>C		No	ClinVar dbSNP
CA163863327 rs6976756	258	R>G		No	ClinGen Ensembl
TCGA novel	259	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1424301674 CA368744834	264	A>S		No	ClinGen TOPMed
CA163863341 rs899314491	266	T>K		No	ClinGen Ensembl
rs774315848 CA4419138	274	F>C		No	ClinGen ExAC gnomAD
rs183644599 CA4419139	280	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA368745453 rs1404896008	282	G>V		No	ClinGen gnomAD
TCGA novel	284	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs4520097 CA368746134	312	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA368746179 rs1172943426	314	N>S		No	ClinGen TOPMed
CA163864236 rs1803992	329	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA163864239 rs989899179	332	M>V		No	ClinGen TOPMed gnomAD
CA368746560 rs1242948525	337	L>M		No	ClinGen gnomAD
TCGA novel	340	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs372290123 CA4419165	344	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs913931764 CA163864287	347	D>E		No	ClinGen TOPMed
rs374218623 CA4419168	347	D>N		No	ClinGen ESP ExAC gnomAD
rs374218623 CA368746811	347	D>Y		No	ClinGen ESP ExAC gnomAD
rs113265696 CA163864314	348	L>P		No	ClinGen gnomAD
CA368746851 rs1453467518	349	E>A		No	ClinGen gnomAD
CA368746950 rs1199999323	351	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	351	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4419178 rs753838245	354	I>V		No	ClinGen ExAC gnomAD
rs757417747 CA4419179	355	F>L		No	ClinGen ExAC gnomAD
CA368747044 rs1586179656	358	H>D		No	ClinGen Ensembl
rs745807754 CA4419181	359	A>T		No	ClinGen ExAC gnomAD
rs771939160 CA4419182	360	R>C	Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs772460361 CA163864431	360	R>H		No	ClinGen Ensembl
CA4419183 rs773539785	362	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1803990 CA163864436	363	S>N		No	ClinGen Ensembl
CA163864437 rs977400893	368	I>T		No	ClinGen TOPMed gnomAD
rs201746080 CA163864442	371	E>K		No	ClinGen 1000Genomes ExAC
rs201746080 CA4419184	371	E>Q		No	ClinGen 1000Genomes ExAC
TCGA novel	375	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA163864446 rs371675280	375	R>Q		No	ClinGen ESP TOPMed
TCGA novel	384	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1337766156 CA368747487	388	V>I		No	ClinGen TOPMed
rs201353285 CA4419210	390	T>I		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	391	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1461546339 CA368747571	394	M>V		No	ClinGen gnomAD
rs974031148 CA163864640	395	F>L		No	ClinGen Ensembl
CA368747621 rs1182603205	396	A>T		No	ClinGen TOPMed gnomAD
COSM461713 rs760946308 CA4419212	397	I>M	cervix Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA4419215 rs762149278	400	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs776663282 CA4419214	400	R>W		No	ClinGen ExAC gnomAD
TCGA novel	401	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765372278 CA4419216	403	I>L		No	ClinGen ExAC gnomAD
rs1586180390 CA368747700	403	I>N		No	ClinGen Ensembl
rs1160902952 CA368747715	404	A>G		No	ClinGen TOPMed
CA4419217 rs377111119	405	T>I		No	ClinGen ESP ExAC gnomAD
rs766216737 CA4419219	407	K>R		No	ClinGen ExAC gnomAD
TCGA novel	409	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751517040 CA4419220	412	A>S		No	ClinGen ExAC TOPMed gnomAD
rs754669233 CA4419221	413	V>I		No	ClinGen ExAC gnomAD
rs1338736968 CA368747935	417	I>M		No	ClinGen gnomAD
CA4419222 rs781059128	419	S>F		No	ClinGen ExAC gnomAD
rs1253679349 CA368748005	422	K>R		No	ClinGen gnomAD
TCGA novel	428	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs370553048 CA163864728	428	R>H		No	ClinGen ESP gnomAD
rs571188683 CA4419225	431	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD

No associated diseases with P35998

4 regional properties for P35998

Type	Name	Position	InterPro Accession
domain	AAA+ ATPase domain	208 - 347	IPR003593
domain	ATPase, AAA-type, core	212 - 344	IPR003959
conserved_site	ATPase, AAA-type, conserved site	315 - 333	IPR003960
domain	AAA ATPase, AAA+ lid domain	367 - 411	IPR041569

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm	Colocalizes with TRIM5 in cytoplasmic bodies
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

13 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic ribonucleoprotein granule	A ribonucleoprotein granule located in the cytoplasm.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
ficolin-1-rich granule lumen	Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
P-body	A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
proteasome accessory complex	A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex.
proteasome complex	A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
proteasome regulatory particle, base subcomplex	The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.
secretory granule lumen	The volume enclosed by the membrane of a secretory granule.

3 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
proteasome-activating activity	Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.

4 GO annotations of biological process

Name	Definition
osteoblast differentiation	The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
positive regulation of proteasomal protein catabolic process	Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process.
proteasome-mediated ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

9 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P33299	RPT1	26S proteasome regulatory subunit 7 homolog	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q5E9F9	PSMC2	26S proteasome regulatory subunit 7	Bos taurus (Bovine)	PR
P62333	PSMC6	26S proteasome regulatory subunit 10B	Homo sapiens (Human)	PR
P43686	PSMC4	26S proteasome regulatory subunit 6B	Homo sapiens (Human)	PR
P17980	PSMC3	26S proteasome regulatory subunit 6A	Homo sapiens (Human)	PR
P62195	PSMC5	26S proteasome regulatory subunit 8	Homo sapiens (Human)	PR
P46471	Psmc2	26S proteasome regulatory subunit 7	Mus musculus (Mouse)	PR
Q63347	Psmc2	26S proteasome regulatory subunit 7	Rattus norvegicus (Rat)	PR
Q0WQM8	At1g53790	F-box protein At1g53790	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MPDYLGADQR	KTKEDEKDDK	PIRALDEGDI	ALLKTYGQST	YSRQIKQVED	DIQQLLKKIN
70	80	90	100	110	120
ELTGIKESDT	GLAPPALWDL	AADKQTLQSE	QPLQVARCTK	IINADSEDPK	YIINVKQFAK
130	140	150	160	170	180
FVVDLSDQVA	PTDIEEGMRV	GVDRNKYQIH	IPLPPKIDPT	VTMMQVEEKP	DVTYSDVGGC
190	200	210	220	230	240
KEQIEKLREV	VETPLLHPER	FVNLGIEPPK	GVLLFGPPGT	GKTLCARAVA	NRTDACFIRV
250	260	270	280	290	300
IGSELVQKYV	GEGARMVREL	FEMARTKKAC	LIFFDEIDAI	GGARFDDGAG	GDNEVQRTML
310	320	330	340	350	360
ELINQLDGFD	PRGNIKVLMA	TNRPDTLDPA	LMRPGRLDRK	IEFSLPDLEG	RTHIFKIHAR
370	380	390	400	410	420
SMSVERDIRF	ELLARLCPNS	TGAEIRSVCT	EAGMFAIRAR	RKIATEKDFL	EAVNKVIKSY
430
AKFSATPRYM	TYN