AiPD: Autoinhibited Protein Database

P43686

Gene name	PSMC4 (MIP224, TBP7)
Protein name	26S proteasome regulatory subunit 6B
Names	26S proteasome AAA-ATPase subunit RPT3, MB67-interacting protein, MIP224, Proteasome 26S subunit ATPase 4, Tat-binding protein 7, TBP-7
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5704
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-60 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

61 structures for P43686

Entry ID	Method	Resolution	Chain	Position	Source
2DVW	X-ray	230 A	B	337-418	PDB
5GJQ	EM	450 A	K	1-418	PDB
5GJR	EM	350 A	K/y	1-418	PDB
5L4G	EM	402 A	K	1-418	PDB
5LN3	EM	680 A	K	1-418	PDB
5M32	EM	380 A	e	1-418	PDB
5T0C	EM	380 A	AD/BD	1-418	PDB
5T0G	EM	440 A	D	1-418	PDB
5T0H	EM	680 A	D	1-418	PDB
5T0I	EM	800 A	D	1-418	PDB
5T0J	EM	800 A	D	1-418	PDB
5VFP	EM	420 A	D	39-418	PDB
5VFQ	EM	420 A	D	39-418	PDB
5VFR	EM	490 A	D	39-418	PDB
5VFS	EM	360 A	D	1-418	PDB
5VFT	EM	700 A	D	39-418	PDB
5VFU	EM	580 A	D	39-418	PDB
5VGZ	EM	370 A	D	39-145	PDB
5VHF	EM	570 A	D	39-406	PDB
5VHH	EM	610 A	D	39-406	PDB
5VHI	EM	680 A	D	39-406	PDB
5VHJ	EM	850 A	D	145-406	PDB
5VHM	EM	830 A	D	145-406	PDB
5VHN	EM	730 A	D	145-406	PDB
5VHO	EM	830 A	D	145-406	PDB
5VHP	EM	790 A	D	145-406	PDB
5VHQ	EM	890 A	D	145-406	PDB
5VHR	EM	770 A	D	145-406	PDB
5VHS	EM	880 A	D	39-406	PDB
6MSB	EM	300 A	D	1-418	PDB
6MSD	EM	320 A	D	1-418	PDB
6MSE	EM	330 A	P/p	152-198	PDB
6MSG	EM	350 A	D	1-418	PDB
6MSH	EM	360 A	D	1-418	PDB
6MSJ	EM	330 A	D	1-418	PDB
6MSK	EM	320 A	D	1-418	PDB
6WJD	EM	480 A	D	1-418	PDB
6WJN	EM	570 A	D	39-418	PDB
7QXN	EM	370 A	D	1-418	PDB
7QXP	EM	360 A	D	1-418	PDB
7QXU	EM	430 A	D	1-418	PDB
7QXW	EM	410 A	D	1-418	PDB
7QXX	EM	440 A	D	1-418	PDB
7QY7	EM	470 A	D	1-418	PDB
7QYA	EM	480 A	D	1-418	PDB
7QYB	EM	410 A	D	1-418	PDB
7W37	EM	300 A	D	1-418	PDB
7W38	EM	310 A	D	1-418	PDB
7W39	EM	320 A	D	1-418	PDB
7W3A	EM	350 A	D	1-418	PDB
7W3B	EM	360 A	D	1-418	PDB
7W3C	EM	340 A	D	1-418	PDB
7W3F	EM	330 A	D	1-418	PDB
7W3G	EM	320 A	D	1-418	PDB
7W3H	EM	320 A	D	1-418	PDB
7W3I	EM	350 A	D	1-418	PDB
7W3J	EM	350 A	D	1-418	PDB
7W3K	EM	360 A	D	1-418	PDB
7W3M	EM	350 A	D	1-418	PDB
8CVT	EM	300 A	D	1-418	PDB
AF-P43686-F1	Predicted				AlphaFoldDB

189 variants for P43686

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1599725225 CA405845523	3	E>G		No	Ensembl ClinGen
CA9438346 rs755938113	3	E>K		No	ExAC gnomAD ClinGen
rs777701297 CA9438347	4	I>M		No	ClinGen ExAC gnomAD
CA9438348 rs571861723	5	G>R		No	1000Genomes ExAC gnomAD ClinGen
CA405845533 rs571861723	5	G>S		No	ClinGen 1000Genomes ExAC gnomAD
CA9438349 rs532888816	6	I>V		No	1000Genomes ExAC gnomAD ClinGen
rs1599725257 CA405845554	8	V>G		No	Ensembl ClinGen
rs202032108 CA308362320	8	V>M		No	1000Genomes ClinGen
rs1319988474 CA405845568	10	K>R		No	gnomAD ClinGen
TCGA novel	10	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746057682 CA9438351	11	A>S		No	ClinGen ExAC TOPMed gnomAD
rs746057682 CA9438352	11	A>T		No	ExAC TOPMed gnomAD ClinGen
TCGA novel	12	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775717764 CA9438353	12	Q>P		No	ClinGen ExAC gnomAD
rs775717764 CA405845580	12	Q>R		No	ClinGen ExAC gnomAD
rs1260095206 CA405845612	15	I>F		No	gnomAD ClinGen
CA9438376 rs773666439	15	I>N		No	ExAC TOPMed gnomAD ClinGen
CA405845626 rs1409412450	17	A>E		No	gnomAD ClinGen
CA405845627 rs1409412450	17	A>G		No	gnomAD ClinGen
rs1409412450 CA405845628	17	A>V		No	ClinGen gnomAD
rs746609399 CA308362414	20	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA9438378 rs149889186	21	S>A		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA405845651 rs1314952045	22	R>Q		No	ClinGen gnomAD
rs1056775620 CA308362415	22	R>W		No	ClinGen TOPMed gnomAD
rs1407818738 CA405845656	23	P>L		No	TOPMed gnomAD ClinGen
CA9438379 rs752426616	23	P>S		No	ClinGen ExAC gnomAD
CA9438380 rs760361475	25	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA9438383 rs368678447	26	G>S		No	ESP ExAC TOPMed gnomAD ClinGen
CA405845677 rs1275903399	27	L>M		No	ClinGen gnomAD
CA308362416 rs143871854	28	S>F		No	ClinGen ESP gnomAD
CA9438384 rs778917527	28	S>P		No	ExAC gnomAD ClinGen
CA9438385 rs11542842	29	F>L		No	ExAC gnomAD ClinGen
rs1282080774 CA405845698	31	G>S		No	gnomAD ClinGen
CA405845727 rs1406619574	35	E>A		No	ClinGen Ensembl
CA405845732 rs779477313	36	D>N		No	ExAC TOPMed gnomAD ClinGen
rs779477313 CA9438387	36	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA405845751 rs1471451056	38	E>D		No	ClinGen TOPMed gnomAD
rs769054705 CA9438389	39	D>A		No	ExAC ClinGen
rs1056764825 CA308362417	41	Y>C		No	ClinGen TOPMed
rs1056764825 CA9438391	41	Y>S		No	TOPMed ClinGen
CA405845771 rs1454725432	42	S>G		No	ClinGen gnomAD
CA405845770 rs1454725432	42	S>R		No	ClinGen gnomAD
rs267605481 CA9438394	43	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1368991633 CA405845780	43	R>H		No	TOPMed gnomAD ClinGen
TCGA novel	45	K>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA308362431 rs11542835	50	E>*		No	Ensembl ClinGen
CA405845853 rs1568373872	52	E>K		No	Ensembl ClinGen
rs1341005677 CA405845903	56	V>M		No	gnomAD ClinGen
rs941422179 CA308362433	59	E>G		No	ClinGen Ensembl
TCGA novel	63	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405846060 rs1295252189	66	K>R		No	ClinGen TOPMed
CA405846117 rs1193967666	70	K>R		No	gnomAD ClinGen
rs1042989 CA308362435	73	L>F		No	Ensembl ClinGen
rs1348525158 CA405846183	75	A>S		No	TOPMed ClinGen
rs746586299 CA9438419	81	R>*		No	ExAC TOPMed gnomAD ClinGen
CA405846269 rs1475354799	81	R>Q		No	ClinGen TOPMed
rs867139141 CA308362438	98	Q>K		No	Ensembl ClinGen
rs765036607 CA9438423	103	V>L		No	ClinGen ExAC gnomAD
rs1412525811 CA405846572	104	G>D		No	ClinGen gnomAD
CA9438425 rs140491901	106	T>I		No	ClinGen ESP ExAC gnomAD
TCGA novel	108	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405846611 rs1568373999	108	G>R		No	Ensembl ClinGen
CA405847352 rs1221112732	112	Y>S		No	ClinGen TOPMed
CA405847373 rs1212835731	114	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	gnomAD ClinGen NCI-TCGA
CA9438447 rs774471115	115	I>S		No	ClinGen ExAC gnomAD
CA405847451 rs1277582543	120	D>E		No	ClinGen TOPMed
CA405847455 rs1365063456	121	R>G		No	TOPMed gnomAD ClinGen
CA9438449 rs767656273	121	R>Q		No	ExAC gnomAD ClinGen
CA405847457 rs1365063456	121	R>W		No	TOPMed gnomAD ClinGen
CA405847536 rs764287802	127	N>K		No	ClinGen ExAC TOPMed gnomAD
rs867947770 CA308362648	128	A>G		No	ClinGen Ensembl
CA9438454 rs757607736	130	V>M		No	ClinGen ExAC gnomAD
CA308362649 rs11542836	131	A>V		No	ClinGen Ensembl
CA405847659 rs1568374866	137	N>T		No	ClinGen Ensembl
CA308362652 rs548954243	142	V>L		No	TOPMed gnomAD ClinGen
CA308362651 rs548954243	142	V>M		No	TOPMed gnomAD ClinGen
rs1480163606 CA405847758	145	P>L		No	gnomAD ClinGen
TCGA novel	146	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA308362654 rs963297891	146	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	TOPMed ClinGen NCI-TCGA
rs747871663	146	E>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs994627073 CA308362655	148	D>A		No	ClinGen Ensembl
CA405847787 rs1467082214	148	D>H		No	ClinGen gnomAD
TCGA novel	149	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9438463 rs749080344	150	S>T		No	ExAC gnomAD ClinGen
CA405847853 TCGA novel rs1306116698	152	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	gnomAD ClinGen NCI-TCGA
CA9438464 rs369260443	152	M>T		No	ClinGen ESP ExAC gnomAD
rs1455313071 CA405847891	155	T>I		No	ClinGen gnomAD
rs1026112829 CA308362657	156	S>L		No	ClinGen Ensembl
rs1396812510 CA405847951	157	D>G		No	gnomAD ClinGen
CA308362663 rs987953937	161	D>G		No	ClinGen TOPMed gnomAD
rs775335705 CA9438485	163	M>I		No	ClinGen ExAC gnomAD
CA9438484 rs772119099	163	M>T		No	ExAC gnomAD ClinGen
rs781289010 CA9438486	165	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA9438487 rs768573885	165	A>V		No	ExAC TOPMed ClinGen
CA405848084 rs1213112647	167	I>N		No	ClinGen gnomAD
TCGA novel	167	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405848116 rs1485996947	170	M>V		No	ClinGen gnomAD
rs1037387156 CA308362665	172	I>N		No	TOPMed ClinGen
CA9438490 rs373413671	172	I>V		No	ESP ExAC TOPMed gnomAD ClinGen
TCGA novel	174	K>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763358989 CA9438492	176	E>*		No	ClinGen ExAC TOPMed gnomAD
rs1399452896 CA405848230 COSM364471	178	R>Q	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA405848314 rs1199469653	185	L>I		No	TOPMed ClinGen
rs763454110 CA9438496	186	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA405848338 rs1355040101	187	H>Y		No	gnomAD ClinGen
rs1381319283 CA405848368 COSM3823089	189	E>K	Variant assessed as Somatic; 4.626e-05 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA405848380 rs1221942654	190	L>F		No	gnomAD ClinGen
CA9438499 rs778764576	192	K>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA405848495 rs1204244181	195	G>C		No	ClinGen gnomAD
rs754861365 CA9438527	197	D>N		No	ClinGen ExAC gnomAD
CA405848532 rs1394490377	198	P>A		No	ClinGen gnomAD
CA405848533 rs1394490377	198	P>S		No	ClinGen gnomAD
rs372675589 CA9438529	199	P>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA308362677 rs372675589	199	P>L		No	ESP ExAC TOPMed gnomAD ClinGen
CA9438532 rs777852571	200	R>*		No	ClinGen ExAC TOPMed gnomAD
TCGA novel rs765768285	200	R>P	Variant assessed as Somatic; impact. Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1408045834 CA405848560	200	R>Q		No	ClinGen gnomAD
CA308362678 rs576365261	202	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	TOPMed gnomAD ClinGen NCI-TCGA
CA405848750 rs1287075186	216	A>S		No	TOPMed ClinGen
rs774574844 CA9438535	218	A>V		No	ClinGen ExAC gnomAD
rs1337010415 CA405848828	222	H>R		No	gnomAD ClinGen
TCGA novel	226	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9438555 rs776014996	226	A>V		No	ClinGen ExAC gnomAD
rs1185494356 CA405849943 COSM996506	229	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	gnomAD ClinGen cosmic curated NCI-TCGA
CA9438561 rs751185836	234	E>D		No	ClinGen ExAC gnomAD
rs1302621302 CA405849993	235	F>L		No	TOPMed ClinGen
TCGA novel	245	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405850068 rs1435001607	246	M>I		No	ClinGen TOPMed
CA9438564 rs752494519	248	R>Q		No	ExAC gnomAD ClinGen
rs767242949 CA405850077	248	R>W		No	ClinGen ExAC TOPMed gnomAD
CA405850105 rs1428488237	252	R>H		No	TOPMed ClinGen
rs753838327 CA9438567	257	N>I		No	ClinGen ExAC
CA9438568 rs757396939	258	A>P		No	ClinGen ExAC gnomAD
rs1568376985 CA405850149	259	P>S		No	Ensembl ClinGen
CA9438570 rs746051791	261	I>V		No	ClinGen ExAC gnomAD
CA405850182 rs1484813224	264	I>V		No	ClinGen gnomAD
rs1267553715 CA405850197	266	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	269	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	276	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405850282 rs1469223244	278	Q>*		No	gnomAD ClinGen
CA405850281 rs1469223244	278	Q>E		No	ClinGen gnomAD
TCGA novel	278	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1568377136 CA405850318	282	D>N		No	Ensembl ClinGen
rs1599730066 CA405850346	285	V>G		No	ClinGen Ensembl
TCGA novel	297	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1052083828 CA308363201	304	N>I		No	Ensembl ClinGen
rs1599730180 CA405850512	307	V>G		No	ClinGen Ensembl
TCGA novel	312	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9438626 rs766510583	313	R>T		No	ClinGen ExAC gnomAD
rs1265453769 CA405850559	314	A>G		No	TOPMed gnomAD ClinGen
rs1599730196 CA405850569	316	T>P		No	Ensembl ClinGen
rs28366821 CA308363211	318	D>Y		No	Ensembl ClinGen
rs370184381 CA9438627	319	P>L		No	ClinGen ESP ExAC gnomAD
COSM996509 rs756474011 CA9438631	323	R>W	endometrium Variant assessed as Somatic; 4.639e-05 impact. [Cosmic, NCI-TCGA]	No	ExAC gnomAD ClinGen cosmic curated NCI-TCGA
COSM996510 rs753685467 CA9438634	329	R>C	Variant assessed as Somatic; 4.63e-05 impact. endometrium [NCI-TCGA, Cosmic]	No	ExAC gnomAD ClinGen cosmic curated NCI-TCGA
CA405850644 rs1401024659	329	R>H		No	TOPMed ClinGen
rs779468222 CA9438635	332	E>Q		No	ExAC gnomAD ClinGen
TCGA novel	333	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746586422 CA9438636	338	R>C		No	ExAC TOPMed gnomAD ClinGen
TCGA novel	345	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405850796 rs1227604370	351	K>R		No	gnomAD ClinGen
CA405850806 rs1274114311	352	M>I		No	gnomAD ClinGen
rs376905637 CA9438640	355	S>P		No	ESP ExAC gnomAD ClinGen
rs773158269 CA9438641 CA405850834	356	E>D		No	ClinGen ExAC gnomAD
CA405850847 rs1284921126	358	V>A		No	ClinGen gnomAD
CA9438642 rs762917882	363	Y>H		No	ClinGen ExAC gnomAD
rs745847777 CA9438662	365	A>S		No	ExAC gnomAD ClinGen
CA9438663 rs771995511	368	D>G		No	ClinGen ExAC gnomAD
rs777406855 CA9438664	369	K>T		No	ExAC gnomAD ClinGen
rs760738061 CA9438665	375	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs763366030 CA9438688	382	S>G		No	ExAC gnomAD ClinGen
rs766968064 CA9438689	383	G>A		No	ExAC gnomAD ClinGen
TCGA novel	386	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9438690 rs752127743	388	R>C		No	ExAC gnomAD ClinGen
CA405851355 rs1192629472	388	R>H		No	ClinGen gnomAD
CA405851356 rs1192629472	388	R>P		No	gnomAD ClinGen
rs1424317805 CA405851389	391	R>C		No	TOPMed gnomAD ClinGen
CA405851394 rs1478729210	391	R>H		No	gnomAD ClinGen
CA405851407 rs1461456117	392	Y>C		No	TOPMed ClinGen
CA9438692 rs374359098	393	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs374359098 CA9438693	393	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs778782949 CA9438695	394	V>I		No	ClinGen ExAC TOPMed gnomAD
CA405851481 rs1358196230	398	D>G		No	ClinGen gnomAD
rs1415964920 CA405851507	400	E>K		No	TOPMed ClinGen
rs780086067 CA9438699	406	V>I		No	ClinGen ExAC gnomAD
rs1357086595 CA405851660	411	E>G		No	ClinGen gnomAD
CA9438701 rs768676877	411	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1568377715 CA405851680	412	Q>H		No	ClinGen Ensembl
CA405851764 rs1488078565	418	K>T		No	gnomAD ClinGen

No associated diseases with P43686

5 regional properties for P43686

Type	Name	Position	InterPro Accession
domain	AAA+ ATPase domain	198 - 337	IPR003593
domain	ATPase, AAA-type, core	202 - 335	IPR003959
conserved_site	ATPase, AAA-type, conserved site	305 - 323	IPR003960
domain	Proteasomal ATPase OB C-terminal domain	89 - 144	IPR032501
domain	AAA ATPase, AAA+ lid domain	358 - 401	IPR041569

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

10 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
cytosolic proteasome complex	A proteasome complex found in the cytosol of a cell.
inclusion body	A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
proteasome accessory complex	A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex.
proteasome complex	A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
proteasome regulatory particle, base subcomplex	The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.
synapse	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

3 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
proteasome-activating activity	Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.

3 GO annotations of biological process

Name	Definition
blastocyst development	The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.
proteasome-mediated ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
proteolysis	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P33298	RPT3	26S proteasome regulatory subunit 6B homolog	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P62333	PSMC6	26S proteasome regulatory subunit 10B	Homo sapiens (Human)	PR
P17980	PSMC3	26S proteasome regulatory subunit 6A	Homo sapiens (Human)	PR
P35998	PSMC2	26S proteasome regulatory subunit 7	Homo sapiens (Human)	PR
P62195	PSMC5	26S proteasome regulatory subunit 8	Homo sapiens (Human)	PR

10	20	30	40	50	60
MEEIGILVEK	AQDEIPALSV	SRPQTGLSFL	GPEPEDLEDL	YSRYKKLQQE	LEFLEVQEEY
70	80	90	100	110	120
IKDEQKNLKK	EFLHAQEEVK	RIQSIPLVIG	QFLEAVDQNT	AIVGSTTGSN	YYVRILSTID
130	140	150	160	170	180
RELLKPNASV	ALHKHSNALV	DVLPPEADSS	IMMLTSDQKP	DVMYADIGGM	DIQKQEVREA
190	200	210	220	230	240
VELPLTHFEL	YKQIGIDPPR	GVLMYGPPGC	GKTMLAKAVA	HHTTAAFIRV	VGSEFVQKYL
250	260	270	280	290	300
GEGPRMVRDV	FRLAKENAPA	IIFIDEIDAI	ATKRFDAQTG	ADREVQRILL	ELLNQMDGFD
310	320	330	340	350	360
QNVNVKVIMA	TNRADTLDPA	LLRPGRLDRK	IEFPLPDRRQ	KRLIFSTITS	KMNLSEEVDL
370	380	390	400	410
EDYVARPDKI	SGADINSICQ	ESGMLAVREN	RYIVLAKDFE	KAYKTVIKKD	EQEHEFYK