AiPD: Autoinhibited Protein Database

P62333

Gene name	PSMC6 (SUG2)
Protein name	26S proteasome regulatory subunit 10B
Names	26S proteasome AAA-ATPase subunit RPT4, Proteasome 26S subunit ATPase 6, Proteasome subunit p42
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5706
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

11-82 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

11-82 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

39 structures for P62333

Entry ID	Method	Resolution	Chain	Position	Source
5GJQ	EM	450 A	L	1-389	PDB
5GJR	EM	350 A	L/z	1-389	PDB
5L4G	EM	402 A	L	1-389	PDB
5LN3	EM	680 A	L	1-389	PDB
5M32	EM	380 A	f	1-379	PDB
5T0C	EM	380 A	AE/BE	1-389	PDB
5T0G	EM	440 A	E	1-389	PDB
5T0H	EM	680 A	E	1-389	PDB
5T0I	EM	800 A	E	1-389	PDB
5T0J	EM	800 A	E	1-389	PDB
5VFP	EM	420 A	E	15-389	PDB
5VFQ	EM	420 A	E	15-389	PDB
5VFR	EM	490 A	E	15-389	PDB
5VFS	EM	360 A	E	1-389	PDB
5VFT	EM	700 A	E	37-389	PDB
5VFU	EM	580 A	E	37-389	PDB
5VGZ	EM	370 A	E	11-114	PDB
5VHF	EM	570 A	E	11-389	PDB
5VHH	EM	610 A	E	11-389	PDB
5VHI	EM	680 A	E	11-389	PDB
5VHJ	EM	850 A	E	128-389	PDB
5VHM	EM	830 A	E	128-389	PDB
5VHN	EM	730 A	E	115-389	PDB
5VHO	EM	830 A	E	128-389	PDB
5VHP	EM	790 A	E	128-389	PDB
5VHQ	EM	890 A	E	128-389	PDB
5VHR	EM	770 A	E	128-389	PDB
5VHS	EM	880 A	E	11-389	PDB
6MSB	EM	300 A	E	1-389	PDB
6MSD	EM	320 A	E	1-389	PDB
6MSE	EM	330 A	E	1-389	PDB
6MSG	EM	350 A	E	1-389	PDB
6MSH	EM	360 A	E	1-389	PDB
6MSJ	EM	330 A	E	1-389	PDB
6MSK	EM	320 A	E	1-389	PDB
6WJN	EM	570 A	E	15-389	PDB
7QY7	EM	470 A	E	1-389	PDB
8CVT	EM	300 A	E	1-389	PDB
AF-P62333-F1	Predicted				AlphaFoldDB

141 variants for P62333

Variant ID(s)	Position	Change	Diseaes Association	Provenance
CA7189581 rs142367793	4	P>A	No	ClinGen ESP ExAC TOPMed gnomAD
rs1489346771 CA389724314	4	P>L	No	ClinGen TOPMed gnomAD
CA389724313 rs1489346771	4	P>R	No	ClinGen TOPMed gnomAD
CA7189580 rs142367793	4	P>S	No	ClinGen ESP ExAC TOPMed gnomAD
CA7189583 rs753009195	5	R>K	No	ClinGen ExAC
rs777973212 CA389724324	6	D>G	No	ClinGen ExAC gnomAD
CA7189584 rs542227590	6	D>H	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA389724321 rs542227590	6	D>N	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs777973212 CA7189585	6	D>V	No	ClinGen ExAC gnomAD
CA7189586 rs749384722	7	K>E	No	ClinGen ExAC gnomAD
CA7189587 rs771076814	8	A>V	No	ClinGen ExAC TOPMed gnomAD
CA260933969 rs999793856	10	Q>E	No	ClinGen gnomAD
rs779585393 CA7189588	10	Q>R	No	ClinGen ExAC gnomAD
CA389724358 rs1436451444	11	D>E	No	ClinGen gnomAD
rs1394464421 CA389724351	11	D>N	No	ClinGen gnomAD
CA389724360 rs1290570124	12	Y>H	No	ClinGen TOPMed
CA7189589 rs151244912	13	R>C	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs772535111 CA7189591	14	K>R	No	ClinGen ExAC gnomAD
rs1594845503 CA389724406	18	E>D	No	ClinGen Ensembl
rs1415690800 CA389724420	20	K>R	No	ClinGen TOPMed
rs745763726 CA389724433	22	I>F	No	ClinGen gnomAD
rs745763726 CA260934002	22	I>L	No	ClinGen gnomAD
CA260934009 rs922789384	23	D>A	No	ClinGen TOPMed
CA389724481 rs1594845522	29	L>V	No	ClinGen Ensembl
rs1255526988 CA389724516	32	Q>E	No	ClinGen TOPMed
rs956227504 CA260934888	37	T>A	No	ClinGen TOPMed gnomAD
CA389724554 rs1309950808	37	T>N	No	ClinGen TOPMed gnomAD
CA389724581 rs1228178955	41	E>K	No	ClinGen TOPMed
rs1252120720 CA389724589	42	K>Q	No	ClinGen gnomAD
rs747859403 CA7189631	52	S>R	No	ClinGen ExAC TOPMed gnomAD
rs769435277 CA7189632	55	Q>P	No	ClinGen ExAC gnomAD
rs1286744683 CA389724729	60	V>G	No	ClinGen TOPMed
CA389724737 rs1451339304	62	K>E	No	ClinGen gnomAD
CA389724748 rs1166387708	63	Q>R	No	ClinGen gnomAD
CA389724763 rs766447066	65	T>I	No	ClinGen ExAC gnomAD
CA7189645 rs766447066	65	T>S	No	ClinGen ExAC gnomAD
CA389724817 rs1316992233	71	V>F	No	ClinGen gnomAD
CA389724829 rs1340761664	73	A>T	No	ClinGen gnomAD
rs773343252 CA7189663	75	N>S	No	ClinGen ExAC TOPMed
CA389724911 rs1290989286	85	R>Q	No	ClinGen gnomAD
rs1479550485 CA389724998	88	D>H	No	ClinGen gnomAD
rs1478092160 CA389725066	92	L>P	No	ClinGen gnomAD
rs761150165 CA7189689	95	G>E	No	ClinGen ExAC gnomAD
rs1379647559 CA389725108	96	T>K	No	ClinGen TOPMed
CA260937045 rs541834964	107	I>V	No	ClinGen Ensembl
rs781214722 CA7189717	112	P>L	No	ClinGen ExAC TOPMed gnomAD
rs11545962 CA260937294	114	E>G	No	ClinGen Ensembl
CA7189719 rs755978557	116	D>H	No	ClinGen ExAC gnomAD
rs1336685592 CA389725491	126	D>E	No	ClinGen gnomAD
CA389725552 rs1456317179	130	V>A	No	ClinGen TOPMed
CA389725568 rs1231171751	131	S>C	No	ClinGen gnomAD
rs1351487758 CA389725584	132	Y>F	No	ClinGen TOPMed
rs1803069 CA260937317	133	S>F	No	ClinGen Ensembl
CA7189720 rs777523457	135	I>S	No	ClinGen ExAC gnomAD
CA389725645 rs1165217588	137	G>R	No	ClinGen TOPMed
rs1239858090 CA389725686	140	E>G	No	ClinGen gnomAD
CA260937331 rs899785613	142	I>M	No	ClinGen Ensembl
rs775631269 CA7189723	143	R>G	No	ClinGen ExAC TOPMed gnomAD
rs747132261 CA7189724	143	R>Q	No	ClinGen ExAC TOPMed gnomAD
rs775631269 CA389725720	143	R>W	No	ClinGen ExAC TOPMed gnomAD
rs1259121416 CA389725728	144	E>K	No	ClinGen gnomAD
CA389726034 rs1282074078	153	L>F	No	ClinGen gnomAD
CA389726042 rs753642513	154	T>I	No	ClinGen ExAC gnomAD
CA7189739 rs753642513	154	T>R	No	ClinGen ExAC gnomAD
rs1335408835 CA389726054	156	P>Q	No	ClinGen TOPMed
rs747167339 CA7189742	157	E>K	No	ClinGen ExAC gnomAD
rs1383242307 CA389726076	159	F>L	No	ClinGen TOPMed
rs779580328 CA260938991	159	F>L	No	ClinGen TOPMed gnomAD
CA7189743 rs768826722	160	Q>R	No	ClinGen ExAC
rs1400222509 CA389726088	161	R>H	No	ClinGen gnomAD
CA389726104 rs1457445565	164	I>V	No	ClinGen TOPMed
CA7189747 rs773800840	173	Y>C	No	ClinGen ExAC gnomAD
rs1162198807 CA389726166	173	Y>H	No	ClinGen TOPMed
CA389726207 rs1435670828	177	G>A	No	ClinGen TOPMed
CA7189763 rs756217809	178	T>M	No	ClinGen ExAC TOPMed gnomAD
CA389726228 rs1594851579	181	T>P	No	ClinGen Ensembl
rs771473061 CA7189766	185	R>*	No	ClinGen ExAC TOPMed gnomAD
rs771473061 CA389726253	185	R>G	No	ClinGen ExAC TOPMed gnomAD
rs1220814053 CA389726254	185	R>Q	No	ClinGen TOPMed
CA389726265 rs1156992215	187	V>I	No	ClinGen gnomAD
CA389726299 rs1278687625	192	D>Y	No	ClinGen TOPMed
CA260941740 rs866595005	193	C>Y	No	ClinGen Ensembl
CA389726317 rs1368171298	194	N>S	No	ClinGen gnomAD
rs967216694 CA260941795	203	I>V	No	ClinGen gnomAD
CA389726407 rs1294461109	205	D>E	No	ClinGen TOPMed gnomAD
rs977361462 CA260941814	213	R>H	No	ClinGen Ensembl
CA260941819 rs377094174	220	N>S	No	ClinGen ESP gnomAD
rs1283345320 CA389726522	221	Y>F	No	ClinGen TOPMed
rs1275641635 CA389726531	223	R>G	No	ClinGen gnomAD
CA7189787 rs775045062	227	P>L	No	ClinGen ExAC gnomAD
rs746641590 CA7189788	229	I>T	No	ClinGen ExAC gnomAD
rs1241698659 CA389726644	238	I>V	No	ClinGen TOPMed gnomAD
rs780762950 CA7189809	247	T>A	No	ClinGen ExAC gnomAD
CA260942247 rs749681528	251	R>G	No	ClinGen Ensembl
CA260943315 rs1042135398	264	M>V	No	ClinGen TOPMed
CA389726885 rs1594853263	269	T>N	No	ClinGen Ensembl
rs1384005369 CA389726895	271	H>Y	No	ClinGen TOPMed
CA389726955 rs1362691659	279	T>A	No	ClinGen TOPMed
rs1331187743 CA389726956	279	T>K	No	ClinGen gnomAD
CA7189831 rs369082655	284	T>I	No	ClinGen ESP ExAC gnomAD
rs143101806 CA7189833	287	P>S	No	ClinGen ESP ExAC TOPMed gnomAD
CA260943360 rs61734473	290	L>V	No	ClinGen Ensembl
rs1191175608 CA389727056	295	L>S	No	ClinGen TOPMed gnomAD
CA389727089 rs1266296760	299	I>M	No	ClinGen gnomAD
rs1394008432 CA389727107	300	H>L	No	ClinGen TOPMed
rs1370989311 CA389727091	300	H>Y	No	ClinGen TOPMed
rs779026305 CA7189855	301	I>T	No	ClinGen ExAC gnomAD
rs756781602 CA7189854	301	I>V	No	ClinGen ExAC gnomAD
rs745777005 CA7189856	302	D>N	No	ClinGen ExAC gnomAD
rs772049323 CA7189857	303	L>V	No	ClinGen ExAC gnomAD
rs1454329535 CA389727124	303	L>W	No	ClinGen gnomAD
CA389727142 rs1171191828	306	E>K	No	ClinGen TOPMed
rs1360092477 CA389727161	308	A>E	No	ClinGen gnomAD
CA7189860 rs770064263	318	G>D	No	ClinGen ExAC gnomAD
rs770064263 CA389727230	318	G>V	No	ClinGen ExAC gnomAD
CA260943487 rs141153483	321	T>R	No	ClinGen ESP
rs1234585672 CA389727327	330	A>E	No	ClinGen gnomAD
rs1234585672 CA389727328	330	A>G	No	ClinGen gnomAD
rs150366196 CA7189874	331	I>V	No	ClinGen ESP ExAC TOPMed gnomAD
rs1486874597 CA389727338	332	V>L	No	ClinGen gnomAD
rs556787109 CA7189875	333	K>R	No	ClinGen ExAC TOPMed gnomAD
CA389727358 rs1438582072	335	S>L	No	ClinGen gnomAD
CA260945121 rs369530713	342	D>E	No	ClinGen ESP
CA389727410 rs1481240614	343	L>M	No	ClinGen gnomAD
CA260945126 rs1035876368	344	R>S	No	ClinGen Ensembl
rs1179096966 CA389727429	346	V>I	No	ClinGen gnomAD
CA7189877 rs768293547	351	G>S	No	ClinGen ExAC gnomAD
CA7189890 rs753582556	352	M>V	No	ClinGen ExAC gnomAD
rs1400637963 CA389727497	354	A>T	No	ClinGen gnomAD
CA389727510 rs1411400060	356	R>G	No	ClinGen TOPMed gnomAD
CA7189892 rs764914580	356	R>H	No	ClinGen ExAC gnomAD
CA389727512 rs1411400060	356	R>S	No	ClinGen TOPMed gnomAD
rs1441066205 CA389727529	359	H>N	No	ClinGen gnomAD
rs757929903 CA7189894	360	D>Y	No	ClinGen ExAC gnomAD
rs560603755 CA260946582	365	E>G	No	ClinGen Ensembl
rs1435316510 CA389727594	367	F>L	No	ClinGen gnomAD
rs1309623315 CA389727635	373	K>R	No	ClinGen TOPMed
rs368977300 CA260946587	375	A>D	No	ClinGen ESP TOPMed gnomAD
rs368977300 CA260946589	375	A>G	No	ClinGen ESP TOPMed gnomAD
CA389727659 rs1363122948	377	S>A	No	ClinGen gnomAD
CA389727733 rs1275129779	387	K>R	No	ClinGen gnomAD

No associated diseases with P62333

5 regional properties for P62333

Type	Name	Position	InterPro Accession
domain	AAA+ ATPase domain	166 - 305	IPR003593
domain	ATPase, AAA-type, core	171 - 302	IPR003959
conserved_site	ATPase, AAA-type, conserved site	273 - 291	IPR003960
domain	Proteasomal ATPase OB C-terminal domain	57 - 112	IPR032501
domain	AAA ATPase, AAA+ lid domain	326 - 368	IPR041569

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

10 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
cytosolic proteasome complex	A proteasome complex found in the cytosol of a cell.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
inclusion body	A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
proteasome accessory complex	A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex.
proteasome complex	A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
proteasome regulatory particle, base subcomplex	The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.

5 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
identical protein binding	Binding to an identical protein or proteins.
proteasome-activating activity	Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.
protein-macromolecule adaptor activity	The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.

5 GO annotations of biological process

Name	Definition
positive regulation of inclusion body assembly	Any process that increases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body.
positive regulation of proteasomal protein catabolic process	Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process.
positive regulation of RNA polymerase II transcription preinitiation complex assembly	Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.
proteasome-mediated ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
ubiquitin-dependent ERAD pathway	The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P17980	PSMC3	26S proteasome regulatory subunit 6A	Homo sapiens (Human)	PR
P43686	PSMC4	26S proteasome regulatory subunit 6B	Homo sapiens (Human)	PR
P35998	PSMC2	26S proteasome regulatory subunit 7	Homo sapiens (Human)	PR
P62195	PSMC5	26S proteasome regulatory subunit 8	Homo sapiens (Human)	PR
O17071	rpt-4	Probable 26S proteasome regulatory subunit 10B	Caenorhabditis elegans	PR

10	20	30	40	50	60
MADPRDKALQ	DYRKKLLEHK	EIDGRLKELR	EQLKELTKQY	EKSENDLKAL	QSVGQIVGEV
70	80	90	100	110	120
LKQLTEEKFI	VKATNGPRYV	VGCRRQLDKS	KLKPGTRVAL	DMTTLTIMRY	LPREVDPLVY
130	140	150	160	170	180
NMSHEDPGNV	SYSEIGGLSE	QIRELREVIE	LPLTNPELFQ	RVGIIPPKGC	LLYGPPGTGK
190	200	210	220	230	240
TLLARAVASQ	LDCNFLKVVS	SSIVDKYIGE	SARLIREMFN	YARDHQPCII	FMDEIDAIGG
250	260	270	280	290	300
RRFSEGTSAD	REIQRTLMEL	LNQMDGFDTL	HRVKMIMATN	RPDTLDPALL	RPGRLDRKIH
310	320	330	340	350	360
IDLPNEQARL	DILKIHAGPI	TKHGEIDYEA	IVKLSDGFNG	ADLRNVCTEA	GMFAIRADHD
370	380
FVVQEDFMKA	VRKVADSKKL	ESKLDYKPV