O17071

PR
Gene name
rpt-4 (F23F1.8)
Protein name
Probable 26S proteasome regulatory subunit 10B
Names
26S proteasome AAA-ATPase subunit rpt-4, Proteasome regulatory particle ATPase-like protein 4
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_F23F1.8
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-180 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O17071

Entry ID Method Resolution Chain Position Source
AF-O17071-F1 Predicted AlphaFoldDB

No variants for O17071

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O17071

No associated diseases with O17071

5 regional properties for O17071

Type Name Position InterPro Accession
domain AAA+ ATPase domain 183 - 322 IPR003593
domain ATPase, AAA-type, core 188 - 319 IPR003959
conserved_site ATPase, AAA-type, conserved site 290 - 308 IPR003960
domain Proteasomal ATPase OB C-terminal domain 74 - 129 IPR032501
domain AAA ATPase, AAA+ lid domain 343 - 385 IPR041569

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosolic proteasome complex A proteasome complex found in the cytosol of a cell.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
proteasome regulatory particle, base subcomplex The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
identical protein binding Binding to an identical protein or proteins.
proteasome-activating activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.

4 GO annotations of biological process

Name Definition
positive regulation of RNA polymerase II transcription preinitiation complex assembly Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
regulation of protein stability Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
ubiquitin-dependent ERAD pathway The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P62333 PSMC6 26S proteasome regulatory subunit 10B Homo sapiens (Human) PR
10 20 30 40 50 60
MLLLQFSNMV EPTGPAIVED ERTKALNSYR RKLAECRDIE QKLKDLRKKE SEMTKQFDKS
70 80 90 100 110 120
ENDIKSLQSV GQIVGEVLKQ LSEEKFIVKA TNGPRYVVGC RRSINKEELK QGTRVSLDMT
130 140 150 160 170 180
TLTIMRQLPR EVDPLVYKMS HEDPGNISYS DVGGLAEQIR ELREVVELPL INPELFKRVG
190 200 210 220 230 240
ITPPKGCLLF GPPGTGKTLL ARAVASQLDC NFLKVVSSAI VDKYIGESAR MIREMFNYAR
250 260 270 280 290 300
DHQPCIVFMD EIDAIGGRRF SEGTSADREI QRTLMELLNQ LDGFDSLGKV KVIMATNRPD
310 320 330 340 350 360
TLDPALLRPG RLDRKIEIGL PNEQSRLEIL KIHSNKITKH GEIDFEAVVK LSDGFSAADL
370 380 390 400
RNVCTEAGMF AIRAEREFVI DEDFMKAVRK VGDAKRLETK LDYKPV