AiPD: Autoinhibited Protein Database

Gene name	RPT1 (CIM5, YTA3, YKL145W)
Protein name	26S proteasome regulatory subunit 7 homolog
Names	Protein CIM5, Tat-binding homolog 3
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YKL145W
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-230 (Predicted disordered autoinhibitory region) PR

1-230 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
3JCO	EM	480 A	H	1-467	PDB
3JCP	EM	460 A	H	1-467	PDB
3VLF	X-ray	380 A	B/D	381-467	PDB
4A3V	X-ray	380 A	B/D	378-467	PDB
4CR2	EM	770 A	H	1-467	PDB
4CR3	EM	930 A	H	1-467	PDB
4CR4	EM	880 A	H	1-467	PDB
4JPO	X-ray	500 A	C/D	379-467	PDB
5A5B	EM	950 A	H	1-467	PDB
5MP9	EM	410 A	H	1-467	PDB
5MPA	EM	450 A	H	1-467	PDB
5MPB	EM	780 A	H	1-467	PDB
5MPC	EM	770 A	H	1-467	PDB
5WVI	EM	630 A	H	1-467	PDB
5WVK	EM	420 A	H	1-467	PDB
6EF0	EM	443 A	H	201-457	PDB
6EF1	EM	473 A	H	194-455	PDB
6EF2	EM	427 A	H	194-466	PDB
6EF3	EM	417 A	H	1-467	PDB
6FVT	EM	410 A	H	42-467	PDB
6FVU	EM	450 A	H	42-467	PDB
6FVV	EM	540 A	H	42-458	PDB
6FVW	EM	450 A	H	42-467	PDB
6FVX	EM	490 A	H	42-467	PDB
6FVY	EM	610 A	H	42-467	PDB
6J2C	EM	700 A	H	1-467	PDB
6J2N	EM	750 A	H	1-467	PDB
6J2Q	EM	380 A	H	1-467	PDB
6J2X	EM	380 A	H	1-467	PDB
6J30	EM	450 A	H	1-467	PDB
7QO4	EM	700 A	H	1-467	PDB
7QO5	EM	600 A	H	1-467	PDB
AF-P33299-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for P33299

Type	Name	Position	InterPro Accession
domain	AAA+ ATPase domain	242 - 381	IPR003593
domain	ATPase, AAA-type, core	246 - 378	IPR003959
conserved_site	ATPase, AAA-type, conserved site	349 - 367	IPR003960
domain	AAA ATPase, AAA+ lid domain	406 - 444	IPR041569

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
proteasome complex	A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
proteasome regulatory particle, base subcomplex	The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
proteasome-activating activity	Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.
ubiquitin protein ligase binding	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

Name	Definition
positive regulation of protein catabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
positive regulation of RNA polymerase II transcription preinitiation complex assembly	Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.
proteasome regulatory particle assembly	The aggregation, arrangement and bonding together of a mature, active proteasome regulatory particle complex.
proteasome-mediated ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P33298	RPT3	26S proteasome regulatory subunit 6B homolog	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P40327	RPT2	26S proteasome regulatory subunit 4 homolog	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q01939	RPT6	26S proteasome regulatory subunit 8 homolog	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q5E9F9	PSMC2	26S proteasome regulatory subunit 7	Bos taurus (Bovine)	PR
P35998	PSMC2	26S proteasome regulatory subunit 7	Homo sapiens (Human)	PR
P46471	Psmc2	26S proteasome regulatory subunit 7	Mus musculus (Mouse)	PR
Q63347	Psmc2	26S proteasome regulatory subunit 7	Rattus norvegicus (Rat)	PR