P62142
PR
Gene name |
Ppp1cb |
Protein name |
Serine/threonine-protein phosphatase PP1-beta catalytic subunit |
Names |
PP-1B |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:25594 |
EC number |
3.1.3.16: Phosphoric monoester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P62142
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P62142-F1 | Predicted | AlphaFoldDB |
No variants for P62142
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P62142 | |||||
No associated diseases with P62142
3 regional properties for P62142
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.3.16 | Phosphoric monoester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| glycogen granule | Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein phosphatase type 1 complex | A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity. |
| PTW/PP1 phosphatase complex | A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| myosin phosphatase activity | Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. |
| myosin-light-chain-phosphatase activity | Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate. |
| phosphatase activity | Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. |
| phosphoprotein phosphatase activity | Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| protein serine/threonine phosphatase activity | Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| circadian regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. |
| entrainment of circadian clock by photoperiod | The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night). |
| glycogen metabolic process | The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages. |
| protein dephosphorylation | The process of removing one or more phosphoric residues from a protein. |
| regulation of cell adhesion | Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. |
| regulation of circadian rhythm | Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. |
| regulation of glycogen biosynthetic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. |
| regulation of glycogen catabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P62136 | PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | Homo sapiens (Human) | PR |
| P62140 | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit | Homo sapiens (Human) | PR |
| P62137 | Ppp1ca | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | Mus musculus (Mouse) | PR |
| P62141 | Ppp1cb | Serine/threonine-protein phosphatase PP1-beta catalytic subunit | Mus musculus (Mouse) | PR |
| P48459 | C23G10.1 | Serine/threonine-protein phosphatase C23G10.1 | Caenorhabditis elegans | PR |
| P34430 | F44B9.9 | Uncharacterized protein F44B9.9 | Caenorhabditis elegans | PR |
| O82733 | TOPP7 | Serine/threonine-protein phosphatase PP1 isozyme 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADGELNVDS | LITRLLEVRG | CRPGKIVQMT | EAEVRGLCIK | SREIFLSQPI | LLELEAPLKI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CGDIHGQYTD | LLRLFEYGGF | PPEANYLFLG | DYVDRGKQSL | ETICLLLAYK | IKYPENFFLL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RGNHECASIN | RIYGFYDECK | RRFNIKLWKT | FTDCFNCLPI | AAIVDEKIFC | CHGGLSPDLQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SMEQIRRIMR | PTDVPDTGLL | CDLLWSDPDK | DVQGWGENDR | GVSFTFGADV | VSKFLNRHDL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DLICRAHQVV | EDGYEFFAKR | QLVTLFSAPN | YCGEFDNAGG | MMSVDETLMC | SFQILKPSEK |
| 310 | 320 | ||||
| KAKYQYGGLN | SGRPVTPPRT | ANPPKKR |