AiPD: Autoinhibited Protein Database

P62136

Gene name	PPP1CA (PPP1A)
Protein name	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Names	PP-1A
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5499
EC number	3.1.3.16: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

277-330 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

277-330 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

43 structures for P62136

Entry ID	Method	Resolution	Chain	Position	Source
3E7A	X-ray	163 A	A/B	7-300	PDB
3E7B	X-ray	170 A	A/B	7-300	PDB
3EGG	X-ray	185 A	A/B	7-330	PDB
3EGH	X-ray	200 A	A/B	7-330	PDB
3HVQ	X-ray	220 A	A/B	7-330	PDB
3N5U	X-ray	320 A	A/B	1-300	PDB
3V4Y	X-ray	210 A	A/C/E/G	7-307	PDB
4G9J	X-ray	310 A	A/B	1-330	PDB
4MOV	X-ray	145 A	A/B	7-300	PDB
4MOY	X-ray	220 A	A	7-300	PDB
4MP0	X-ray	210 A	A/C	7-300	PDB
4XPN	X-ray	229 A	A/C	7-300	PDB
5IOH	X-ray	257 A	A/C	7-300	PDB
6ALZ	X-ray	221 A	A/B	7-300	PDB
6CZO	X-ray	295 A	A/C	7-300	PDB
6DCX	X-ray	341 A	A/B	1-330	PDB
6DNO	X-ray	145 A	A	7-300	PDB
6G0I	X-ray	200 A	A	1-330	PDB
6G0J	X-ray	210 A	A	1-330	PDB
6GHM	X-ray	215 A	A/B	7-330	PDB
6OBN	X-ray	270 A	A/B	1-300	PDB
6OBP	X-ray	270 A	A	1-300	PDB
6OBQ	X-ray	184 A	A/B	7-300	PDB
6OBR	X-ray	150 A	A/B	7-300	PDB
6OBS	X-ray	180 A	A/B	7-300	PDB
6OBU	X-ray	195 A	A/B	7-300	PDB
6ZEE	X-ray	190 A	A/B/I/K/P/Q	7-300	PDB
6ZEF	X-ray	194 A	A/B	7-300	PDB
6ZEG	X-ray	109 A	A/B	7-304	PDB
6ZEH	X-ray	130 A	A/B	7-304	PDB
6ZEI	X-ray	139 A	A/B	7-304	PDB
6ZEJ	X-ray	178 A	A/D/F/I/L/O	7-304	PDB
6ZK6	X-ray	190 A	A	1-330	PDB
7QFB	X-ray	205 A	A	7-300	PDB
7QM2	X-ray	269 A	A/C	7-300	PDB
7T0Y	X-ray	180 A	A/C	7-300	PDB
7TVF	X-ray	217 A	C/F	2-330	PDB
7TXH	X-ray	195 A	C/F	7-300	PDB
7UPI	EM	289 A	B	1-330	PDB
8DWK	X-ray	250 A	A/B	7-300	PDB
8DWL	X-ray	200 A	A/C	7-300	PDB
8U5G	X-ray	320 A	A	7-300	PDB
AF-P62136-F1	Predicted				AlphaFoldDB

170 variants for P62136

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA381538288 rs1195927448	2	S>F		No	ClinGen TOPMed
TCGA novel	2	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA381538219 rs1277027424	5	E>D		No	ClinGen gnomAD
rs1040508170 CA224150621	6	K>N		No	ClinGen Ensembl
rs777809830 CA6137069	6	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA6137068 rs758536530	7	L>P		No	ClinGen ExAC gnomAD
rs943825563 CA224150606	9	L>P		No	ClinGen gnomAD
CA224150600 rs908292931	10	D>E		No	ClinGen Ensembl
rs766387418 CA6137066	10	D>G		No	ClinGen ExAC TOPMed gnomAD
rs756043412 CA6137065	11	S>L		No	ClinGen ExAC gnomAD
CA224150599 rs982441873	11	S>T		No	ClinGen Ensembl
CA381538124 rs1421197088	12	I>L		No	ClinGen TOPMed
rs767314521 CA6137063	13	I>V		No	ClinGen ExAC TOPMed gnomAD
rs927377317 CA224150591	14	G>E		No	ClinGen TOPMed
CA6137062 rs761547123	14	G>R		No	ClinGen ExAC gnomAD
CA6137061 rs774088798	15	R>L		No	ClinGen ExAC TOPMed gnomAD
CA381538009 rs1326473191	19	V>M		No	ClinGen TOPMed
rs759063176 CA6137035	22	S>L		No	ClinGen ExAC gnomAD
CA6137034 rs777308177	23	R>Q		No	ClinGen ExAC
CA381537427 rs1453818439	29	Q>E		No	ClinGen gnomAD
TCGA novel	32	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1286863709 CA381537271	34	E>K		No	ClinGen gnomAD
CA381537237 rs1198051383	36	R>G		No	ClinGen gnomAD
CA6137029 rs748334344	37	G>D		No	ClinGen ExAC gnomAD
CA6137031 rs547598243	37	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6137030 rs547598243	37	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA381537025 rs1232429537	45	I>M		No	ClinGen TOPMed
CA224150156 rs895929309	46	F>I		No	ClinGen TOPMed
CA224150148 rs749938499	48	S>T		No	ClinGen Ensembl
CA6137024 rs781160417	52	L>F		No	ClinGen ExAC
rs868163307 CA224150145	56	E>G		No	ClinGen TOPMed
rs1252820051 CA381536818	58	P>L		No	ClinGen TOPMed
rs777432845 CA381536741	61	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1464677331 CA381536722	63	G>S		No	ClinGen gnomAD
CA381536632 rs1438383154	65	I>V		No	ClinGen TOPMed gnomAD
CA381536529 rs1425209726	70	Y>H		No	ClinGen TOPMed
rs1565122218 CA381536486	72	L>F		No	ClinGen Ensembl
CA224150031 rs950965471	78	Y>F		No	ClinGen Ensembl
CA6137001 rs752509154 COSM95044	80	G>S	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA6136997 rs368335875	82	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6136998 rs753463549	82	P>S		No	ClinGen ExAC gnomAD
rs910432711 CA224149996	84	E>D		No	ClinGen TOPMed gnomAD
TCGA novel	84	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750924472 CA6136995	84	E>Q		No	ClinGen ExAC gnomAD
CA381536236 rs768037763	87	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs768037763 CA6136994	87	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA6136992 rs774688459	89	F>L		No	ClinGen ExAC gnomAD
CA381536140 rs1486112747	94	V>M		No	ClinGen gnomAD
rs1167404909 CA381536124	95	D>V		No	ClinGen TOPMed gnomAD
rs1488340584 CA381535948	104	I>T		No	ClinGen TOPMed
CA381535953 rs1320600778	104	I>V		No	ClinGen gnomAD
CA381535861 rs1186521556	109	A>V		No	ClinGen TOPMed
CA381535782 rs1398575142	112	I>M		No	ClinGen gnomAD
CA381535805 rs1298016292	112	I>V		No	ClinGen gnomAD
CA381535779 rs1473710985	113	K>E		No	ClinGen TOPMed
CA224149920 rs368449642	113	K>R		No	ClinGen ESP TOPMed gnomAD
CA381535736 rs1590937260	114	Y>S		No	ClinGen Ensembl
rs971784412 CA381535729	115	P>A		No	ClinGen TOPMed gnomAD
CA381535726 rs1244315422	115	P>R		No	ClinGen gnomAD
CA224149919 rs971784412	115	P>S		No	ClinGen TOPMed gnomAD
TCGA novel	116	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1366852262 CA381535659	118	F>Y		No	ClinGen TOPMed gnomAD
CA224149909 rs866677695	123	G>R		No	ClinGen Ensembl
rs1205717276 CA381535480	128	A>T		No	ClinGen gnomAD
CA381535378 rs1354137773	133	I>M		No	ClinGen TOPMed
TCGA novel	136	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751999455 CA6136975	138	D>G		No	ClinGen ExAC gnomAD
TCGA novel	138	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	139	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1200226054 CA381533972	143	R>C		No	ClinGen TOPMed
COSM1221719 CA381533968 rs1465379397 COSM1221720	143	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA381533936 rs1232562330	145	N>D		No	ClinGen gnomAD
CA381533938 rs1232562330	145	N>H		No	ClinGen gnomAD
rs1175444311 CA381533898	147	K>R		No	ClinGen gnomAD
rs1355877895 CA381533863	149	W>*		No	ClinGen gnomAD
rs758799561 CA6136956	151	T>I		No	ClinGen ExAC TOPMed gnomAD
rs758799561 CA381533824	151	T>S		No	ClinGen ExAC TOPMed gnomAD
CA224149160 rs935023103	160	P>S		No	ClinGen TOPMed
CA6136953 rs759797722	162	A>T		No	ClinGen ExAC gnomAD
CA224149147 rs867868948	163	A>T		No	ClinGen gnomAD
rs1307229649 CA381533557	164	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA381533566 rs1353594037	164	I>V		No	ClinGen gnomAD
CA381533437 rs1590936228	169	I>M		No	ClinGen Ensembl
CA6136951 rs760799660	170	F>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1016779857 CA224149124	170	F>I		No	ClinGen Ensembl
TCGA novel	179	D>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1218172889 CA381533031	183	M>I		No	ClinGen gnomAD
CA6136926 rs776300680	183	M>T		No	ClinGen ExAC gnomAD
CA6136925 rs559186487	184	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs1268181440 CA381532945	186	I>M		No	ClinGen TOPMed gnomAD
rs1429835614 CA381532934	187	R>Q		No	ClinGen TOPMed
rs746578350 CA6136923	187	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1439073072 CA381532916	188	R>Q		No	ClinGen gnomAD
rs777258366 CA6136921	189	I>V		No	ClinGen ExAC gnomAD
rs771504128 CA6136920	191	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
COSM1492685 rs1459437708 COSM1492684 CA381532848	191	R>W	kidney [Cosmic]	No	ClinGen cosmic curated gnomAD
CA381532574 rs1444687650	203	D>G		No	ClinGen TOPMed
TCGA novel	210	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1188634488 CA381532394	212	D>G		No	ClinGen gnomAD
CA381532401 rs1367068828	212	D>Y		No	ClinGen TOPMed
TCGA novel	213	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6136917 rs755411315	214	Q>R		No	ClinGen ExAC gnomAD
CA224148832 rs1020255917	215	G>A		No	ClinGen Ensembl
CA381532266 rs1273880415	218	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA381532200 rs1305960330	221	R>C		No	ClinGen gnomAD
CA381532183 rs1216144898	223	V>I		No	ClinGen gnomAD
TCGA novel	224	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1362342633 CA381532156	225	F>V		No	ClinGen gnomAD
CA6136912 rs767723695	226	T>A		No	ClinGen ExAC gnomAD
CA381532143 rs767723695	226	T>P		No	ClinGen ExAC gnomAD
CA224148783 rs893381757	229	A>T		No	ClinGen Ensembl
rs1204847934 CA381532039	230	E>K		No	ClinGen TOPMed
rs752708519 CA6136910	231	V>L		No	ClinGen ExAC gnomAD
rs772136139 CA224148741	234	K>R		No	ClinGen Ensembl
rs141390658 CA6136906	238	K>R		No	ClinGen ESP ExAC
rs771391700 CA224148733	240	D>N		No	ClinGen Ensembl
CA6136904 rs772793107	246	R>Q		No	ClinGen ExAC gnomAD
CA381531588 rs1200914410	247	A>V		No	ClinGen TOPMed
rs1288805861	250	V>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs758412700 CA6136872	254	G>D		No	ClinGen ExAC gnomAD
CA381531327 rs1475027542	256	E>K		No	ClinGen gnomAD
CA381531303 rs1284030697	257	F>I		No	ClinGen TOPMed
rs779926444 CA6136870	257	F>L		No	ClinGen ExAC gnomAD
rs755953452 CA6136869	260	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1257961099 CA381531197	261	R>Q		No	ClinGen TOPMed gnomAD
CA381531123 rs1590935343	264	V>G		No	ClinGen Ensembl
rs1213510625 CA381531138	264	V>L		No	ClinGen TOPMed gnomAD
rs779839364 CA6136866	270	P>S		No	ClinGen ExAC TOPMed gnomAD
CA381531051 rs1590935313	271	N>H		No	ClinGen Ensembl
rs1270903141 CA381530962	276	F>Y		No	ClinGen gnomAD
rs1439194638 CA381530929	278	N>D		No	ClinGen TOPMed
CA381530921 rs1156845734	278	N>S		No	ClinGen TOPMed
CA381530860 rs1381071014	281	A>T		No	ClinGen gnomAD
CA224148557 rs866152678	281	A>V		No	ClinGen Ensembl
CA381530834 rs1387207762	282	M>L		No	ClinGen TOPMed
CA381530827 rs1364661974	282	M>T		No	ClinGen gnomAD
CA381530841 rs1387207762	282	M>V		No	ClinGen TOPMed
CA381530638 rs760031545	287	E>D		No	ClinGen ExAC TOPMed gnomAD
rs776853710 CA6136859	288	T>I		No	ClinGen ExAC gnomAD
rs1336990447 CA381530575	290	M>L		No	ClinGen TOPMed
rs758115919 CA6136825	295	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6136822 rs754460287	297	K>E		No	ClinGen ExAC gnomAD
rs548987693 CA6136821	297	K>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1389382438 CA381530217	298	P>R		No	ClinGen TOPMed
CA6136818 rs773623660	299	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6136815 rs774510465	300	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	301	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA381530120 rs1478078546 CA381530123	302	N>K		No	ClinGen TOPMed gnomAD
rs1420479869 CA381530071	305	K>T		No	ClinGen gnomAD
CA6136812 rs776485148	307	G>R		No	ClinGen ExAC gnomAD
CA6136810 rs746842596	310	S>G		No	ClinGen ExAC TOPMed gnomAD
CA224148242 rs746842596	310	S>R		No	ClinGen ExAC TOPMed gnomAD
rs777712768 CA6136809	313	N>S		No	ClinGen ExAC TOPMed gnomAD
rs777712768 CA381529904	313	N>T		No	ClinGen ExAC TOPMed gnomAD
CA381529885 rs1289868938	314	P>S		No	ClinGen TOPMed gnomAD
CA381529876 rs1241512739	315	G>R		No	ClinGen gnomAD
rs747823510 CA6136807	316	G>D		No	ClinGen ExAC gnomAD
rs1565120575 CA381529849	317	R>*		No	ClinGen Ensembl
CA381529843 rs1267409256	317	R>Q		No	ClinGen TOPMed
CA381529805 rs1481728007	318	P>L		No	ClinGen TOPMed
CA6136805 rs754485510	320	T>N		No	ClinGen ExAC gnomAD
CA381529760 rs1590934882	320	T>P		No	ClinGen Ensembl
rs1460734162 CA381529715	321	P>S		No	ClinGen TOPMed
rs1414956585 CA381529696	322	P>L		No	ClinGen gnomAD
CA224148176 rs913302876	322	P>S		No	ClinGen Ensembl
rs753366655 CA6136804	323	R>C		No	ClinGen ExAC gnomAD
CA6136803 rs766862399	323	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA381529595 rs140048086	326	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6136799 rs140048086	326	A>T	Variant assessed as Somatic; 4.64e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA6136798 rs151139917	331	K>Y		No	ClinGen ESP ExAC TOPMed gnomAD

No associated diseases with P62136

3 regional properties for P62136

Type	Name	Position	InterPro Accession
domain	Calcineurin-like phosphoesterase domain, ApaH type	60 - 250	IPR004843
domain	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase	30 - 300	IPR006186
domain	Serine-threonine protein phosphatase, N-terminal	9 - 56	IPR031675

Functions

		Description
EC Number	3.1.3.16	Phosphoric monoester hydrolases
Subcellular Localization	Cytoplasm Nucleus Nucleus, nucleoplasm Nucleus, nucleolus	Primarily nuclear and largely excluded from the nucleolus Highly mobile in cells and can be relocalized through interaction with targeting subunits NOM1 plays a role in targeting this protein to the nucleolus In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles Shuttles toward the cytosol during infection with VEEV (PubMed:29769351)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

15 GO annotations of cellular component

Name	Definition
adherens junction	A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendritic spine	A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
glycogen granule	Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perikaryon	The portion of the cell soma (neuronal cell body) that excludes the nucleus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
presynapse	The part of a synapse that is part of the presynaptic cell.
protein phosphatase type 1 complex	A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity.
PTW/PP1 phosphatase complex	A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

8 GO annotations of molecular function

Name	Definition
cadherin binding involved in cell-cell adhesion	Any cadherin binding that occurs as part of the process of cell-cell adhesion.
metal ion binding	Binding to a metal ion.
myosin phosphatase activity	Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.
phosphatase activity	Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
phosphoprotein phosphatase activity	Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
protein phosphatase 1 binding	Binding to a protein phosphatase 1.
protein serine/threonine phosphatase activity	Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
ribonucleoprotein complex binding	Binding to a complex of RNA and protein.

20 GO annotations of biological process

Name	Definition
beta-catenin destruction complex disassembly	The disaggregation of a beta-catenin destruction complex into its constituent components.
branching morphogenesis of an epithelial tube	The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.
cell cycle	The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
circadian regulation of gene expression	Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
dephosphorylation	The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
entrainment of circadian clock by photoperiod	The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
glycogen metabolic process	The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.
lung development	The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
negative regulation of protein binding	Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
peptidyl-serine dephosphorylation	The removal of phosphoric residues from peptidyl-O-phospho-L-serine to form peptidyl-serine.
peptidyl-threonine dephosphorylation	The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.
protein dephosphorylation	The process of removing one or more phosphoric residues from a protein.
regulation of canonical Wnt signaling pathway	Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
regulation of circadian rhythm	Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
regulation of glycogen biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.
regulation of glycogen catabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.
regulation of translational initiation by eIF2 alpha dephosphorylation	Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the dephosphorylation of eIF2 alpha.
response to lead ion	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.

7 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P62140	PPP1CB	Serine/threonine-protein phosphatase PP1-beta catalytic subunit	Homo sapiens (Human)	PR
P62141	Ppp1cb	Serine/threonine-protein phosphatase PP1-beta catalytic subunit	Mus musculus (Mouse)	PR
P62137	Ppp1ca	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	Mus musculus (Mouse)	PR
P62142	Ppp1cb	Serine/threonine-protein phosphatase PP1-beta catalytic subunit	Rattus norvegicus (Rat)	PR
P34430	F44B9.9	Uncharacterized protein F44B9.9	Caenorhabditis elegans	PR
P48459	C23G10.1	Serine/threonine-protein phosphatase C23G10.1	Caenorhabditis elegans	PR
O82733	TOPP7	Serine/threonine-protein phosphatase PP1 isozyme 7	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MSDSEKLNLD	SIIGRLLEVQ	GSRPGKNVQL	TENEIRGLCL	KSREIFLSQP	ILLELEAPLK
70	80	90	100	110	120
ICGDIHGQYY	DLLRLFEYGG	FPPESNYLFL	GDYVDRGKQS	LETICLLLAY	KIKYPENFFL
130	140	150	160	170	180
LRGNHECASI	NRIYGFYDEC	KRRYNIKLWK	TFTDCFNCLP	IAAIVDEKIF	CCHGGLSPDL
190	200	210	220	230	240
QSMEQIRRIM	RPTDVPDQGL	LCDLLWSDPD	KDVQGWGEND	RGVSFTFGAE	VVAKFLHKHD
250	260	270	280	290	300
LDLICRAHQV	VEDGYEFFAK	RQLVTLFSAP	NYCGEFDNAG	AMMSVDETLM	CSFQILKPAD
310	320
KNKGKYGQFS	GLNPGGRPIT	PPRNSAKAKK