P48459

PR
Gene name
C23G10.1
Protein name
Serine/threonine-protein phosphatase C23G10.1
Names
Species
Caenorhabditis elegans
KEGG Pathway
EC number
3.1.3.16: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-67 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P48459

Entry ID Method Resolution Chain Position Source
AF-P48459-F1 Predicted AlphaFoldDB

No variants for P48459

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P48459

No associated diseases with P48459

2 regional properties for P48459

Type Name Position InterPro Accession
domain Calcineurin-like phosphoesterase domain, ApaH type 191 - 384 IPR004843
domain Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 162 - 441 IPR006186

Functions

Description
EC Number 3.1.3.16 Phosphoric monoester hydrolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
myosin phosphatase activity Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.
protein serine/threonine phosphatase activity Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.

1 GO annotations of biological process

Name Definition
defense response to Gram-negative bacterium Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P62140 PPP1CB Serine/threonine-protein phosphatase PP1-beta catalytic subunit Homo sapiens (Human) PR
P62136 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit Homo sapiens (Human) PR
P62141 Ppp1cb Serine/threonine-protein phosphatase PP1-beta catalytic subunit Mus musculus (Mouse) PR
P62137 Ppp1ca Serine/threonine-protein phosphatase PP1-alpha catalytic subunit Mus musculus (Mouse) PR
P62142 Ppp1cb Serine/threonine-protein phosphatase PP1-beta catalytic subunit Rattus norvegicus (Rat) PR
P34430 F44B9.9 Uncharacterized protein F44B9.9 Caenorhabditis elegans PR
O82733 TOPP7 Serine/threonine-protein phosphatase PP1 isozyme 7 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSKKTRVPEV ADDCTKTVYP DPIPMPTCPQ LINDGTSCFL NIILQMLKRA NFHDHFKGDW
70 80 90 100 110 120
QKGKQKMLMH KELQQIFNGK PGPKDVSRLR EMFSNEALKD GPHPLLVALK CLIKMSAVSD
130 140 150 160 170 180
NDVIKEKGAR DKMFQKQSDE SNKMFAEHFI KTLLACKGMT KIRTMDIFRL IHICKKIFTV
190 200 210 220 230 240
QKSMVEIDGP VRICGDLHGQ YPDLIRLFAQ GGFPPDSNYL FLGDYVDRGS FNLEVILLCL
250 260 270 280 290 300
AYKARYPNNF MMLRGNHEVI HINEKYGFKD EVFNRKGEYH DELYPEFNEM MDMMPLVALV
310 320 330 340 350 360
GGRILCMHGG LSQHIKSLDD LRNLRRPFHS EDECLENDIM WSDPAKVSGW TANPRGASVQ
370 380 390 400 410 420
FGENEVKEMC KLLDIDLIVR GHQVVQDGYE FFAGKKLVTV FSAPHYMQSF TNSAAVCKVS
430 440 450
AGLEVSFEVL KPEDIRVEEI KCSAESSCAS DMQQ