O82733
Gene name |
TOPP7 |
Protein name |
Serine/threonine-protein phosphatase PP1 isozyme 7 |
Names |
Type one protein phosphatase 7 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G43380 |
EC number |
3.1.3.16: Phosphoric monoester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O82733
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O82733-F1 | Predicted | AlphaFoldDB |
30 variants for O82733
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00700830 | 5 | T>S | No | 1000Genomes | |
| ENSVATH12439391 | 7 | N>K | No | 1000Genomes | |
| ENSVATH07316829 | 40 | D>E | No | 1000Genomes | |
| ENSVATH12439389 | 53 | A>T | No | 1000Genomes | |
| tmp_5_17421548_G_A | 66 | P>L | No | 1000Genomes | |
| ENSVATH03334917 | 80 | N>S | No | 1000Genomes | |
| tmp_5_17421493_C_A | 84 | L>F | No | 1000Genomes | |
| ENSVATH12439386 | 84 | L>M | No | 1000Genomes | |
| tmp_5_17421456_G_C | 97 | L>V | No | 1000Genomes | |
| ENSVATH14577208 | 157 | V>I | No | 1000Genomes | |
| ENSVATH00700822 | 166 | F>I | No | 1000Genomes | |
| ENSVATH12439374 | 183 | R>K | No | 1000Genomes | |
| ENSVATH00700819 | 183 | R>S | No | 1000Genomes | |
| tmp_5_17421168_C_T | 193 | D>N | No | 1000Genomes | |
| tmp_5_17421165_G_A | 194 | R>C | No | 1000Genomes | |
| ENSVATH12439373 | 207 | K>R | No | 1000Genomes | |
| tmp_5_17421116_C_T | 210 | R>K | No | 1000Genomes | |
| ENSVATH03334916 | 214 | P>S | No | 1000Genomes | |
| ENSVATH14577206 | 226 | D>E | No | 1000Genomes | |
| ENSVATH00700815 | 237 | L>F | No | 1000Genomes | |
| ENSVATH00700811 | 260 | V>L | No | 1000Genomes | |
| ENSVATH00700810 | 294 | S>P | No | 1000Genomes | |
| ENSVATH03334913 | 295 | N>K | No | 1000Genomes | |
| ENSVATH14577183 | 296 | D>E | No | 1000Genomes | |
| tmp_5_17420776_C_A | 297 | K>N | No | 1000Genomes | |
| tmp_5_17420772_A_T | 299 | S>T | No | 1000Genomes | |
| tmp_5_17420767_C_A | 300 | K>N | No | 1000Genomes | |
| ENSVATH14577182 | 309 | A>T | No | 1000Genomes | |
| ENSVATH00700809 | 318 | V>M | No | 1000Genomes | |
| ENSVATH00700803 | 323 | S>N | No | 1000Genomes |
No associated diseases with O82733
3 regional properties for O82733
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.3.16 | Phosphoric monoester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| myosin phosphatase activity | Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. |
| protein serine/threonine phosphatase activity | Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P62136 | PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | Homo sapiens (Human) | PR |
| P62140 | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit | Homo sapiens (Human) | PR |
| P62137 | Ppp1ca | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | Mus musculus (Mouse) | PR |
| P62141 | Ppp1cb | Serine/threonine-protein phosphatase PP1-beta catalytic subunit | Mus musculus (Mouse) | PR |
| P62142 | Ppp1cb | Serine/threonine-protein phosphatase PP1-beta catalytic subunit | Rattus norvegicus (Rat) | PR |
| P34430 | F44B9.9 | Uncharacterized protein F44B9.9 | Caenorhabditis elegans | PR |
| P48459 | C23G10.1 | Serine/threonine-protein phosphatase C23G10.1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDPGTLNSVI | NRLLEAREKP | GKIVQLSETE | IKQLCFVSRD | IFLRQPNLLE | LEAPVKICGD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IHGQYPDLLR | LFEHGGYPPN | SNYLFLGDYV | DRGKQSLETI | CLLLAYKIKF | PENFFLLRGN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HESASINRIY | GFYDECKRRF | SVKIWRIFTD | CFNCLPVAAL | IDERIFCMHG | GLSPELLSLR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QIRDIRRPTD | IPDRGLLCDL | LWSDPDKDVR | GWGPNDRGVS | YTFGSDIVSG | FLKRLDLDLI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CRAHQVVEDG | FEFFANKQLV | TIFSAPNYCG | EFDNAGAMMS | VSEDLTCSFQ | ILKSNDKKSK |
| 310 | 320 | 330 | |||
| FSFGSRGGAK | TSFPYPKVKS | ILSSQNSKEY | N |