AiPD: Autoinhibited Protein Database

P51790

Gene name	CLCN3
Protein name	H(+)/Cl(-) exchange transporter 3
Names	Chloride channel protein 3, ClC-3, Chloride transporter ClC-3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:1182
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-143 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-143 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for P51790

Entry ID	Method	Resolution	Chain	Position	Source
AF-P51790-F1	Predicted				AlphaFoldDB

383 variants for P51790

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA358734888 RCV000623942 rs1553965256	11	Y>C	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
VAR_086219	85	Y>C	NEDHYBA [UniProt]	Yes	UniProt
RCV002051932 VAR_086220 rs1732397227 RCV001289539	252	I>T	Neurodevelopmental disorder with hypotonia and brain abnormalities NEDHYBA [ClinVar, UniProt]	Yes	ClinVar UniProt dbSNP
VAR_086221	324	V>A	NEDHYBA [UniProt]	Yes	UniProt
CA358739536 rs1190062987 VAR_086222	413	A>V	NEDHYBA; unknown pathological significance [UniProt]	Yes	ClinGen UniProt TOPMed dbSNP
RCV001267240 rs1732611964	453	S>I	Inborn genetic diseases [ClinVar]	Yes	ClinVar dbSNP
VAR_086223	453	S>R	NEDHYBA [UniProt]	Yes	UniProt
VAR_086224 RCV001195290 RCV001553775 rs1732900321 RCV001597254	570	T>I	Neurodevelopmental disorder Neurodevelopmental disorder with hypotonia and brain abnormalities NEDHYBA [ClinVar, UniProt]	Yes	ClinVar UniProt dbSNP
VAR_086225	607	I>T	NEDHYBA [UniProt]	Yes	UniProt
VAR_086226	772	V>A	NEDHYBA [UniProt]	Yes	UniProt
rs1386616364 CA358734828	2	E>D		No	ClinGen gnomAD
CA3138159 rs750029741	3	S>T		No	ClinGen ExAC TOPMed gnomAD
rs766254279 CA3138161	8	H>L		No	ClinGen ExAC gnomAD
CA3138162 rs751440151	11	Y>*		No	ClinGen ExAC gnomAD
rs938710480 CA109929107	12	Y>S		No	ClinGen TOPMed
rs1432870238 CA358734898	13	R>G		No	ClinGen TOPMed
CA3138163 rs754831858	13	R>T		No	ClinGen ExAC gnomAD
rs780940007 CA3138164	14	N>K		No	ClinGen ExAC gnomAD
CA109929123 rs1057457298	14	N>S		No	ClinGen TOPMed gnomAD
rs757213816 CA3138166	17	N>S		No	ClinGen ExAC TOPMed gnomAD
CA109929134 rs916012724	18	S>G		No	ClinGen TOPMed
rs779026941 CA3138167	19	I>V		No	ClinGen ExAC gnomAD
rs1482637391 CA358734960	22	A>T		No	ClinGen TOPMed
CA358735019 rs1412011228	30	D>H		No	ClinGen gnomAD
rs780368756 CA3138170	32	A>T		No	ClinGen ExAC gnomAD
CA109929178 rs903364926	36	M>T		No	ClinGen Ensembl
CA3138171 rs747298399	37	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1410043115 CA358735095	41	S>P		No	ClinGen gnomAD
CA109929213 rs748721807	42	E>Q		No	ClinGen Ensembl
rs1347716008 CA358735112	43	D>G		No	ClinGen TOPMed
CA3138174 rs762388847	45	N>S		No	ClinGen ExAC gnomAD
TCGA novel	45	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358735140 rs1278355728	47	L>S		No	ClinGen TOPMed
rs769424677 CA3138175	49	G>D		No	ClinGen ExAC TOPMed gnomAD
CA3138213 rs781390349	54	G>V		No	ClinGen ExAC TOPMed gnomAD
CA3138214 rs201334655	55	T>A		No	ClinGen ExAC gnomAD
CA109958407 rs201334655	55	T>S		No	ClinGen ExAC gnomAD
rs756569255 CA3138215	56	H>L		No	ClinGen ExAC gnomAD
CA3138216 rs549590310	56	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA109958413 rs370632344	59	M>V		No	ClinGen ESP TOPMed
rs1581242261 CA358735716	64	S>T		No	ClinGen Ensembl
CA3138218 rs770557420	65	I>T		No	ClinGen ExAC gnomAD
rs1217887183 CA358735735	67	S>G		No	ClinGen TOPMed
CA3138220 rs745483415	68	S>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	68	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3138221 rs771793397	69	T>A		No	ClinGen ExAC gnomAD
CA3138223 rs760416841	70	H>N		No	ClinGen ExAC gnomAD
rs760416841 CA3138224	70	H>Y		No	ClinGen ExAC gnomAD
rs776486775 CA3138225	76	D>E		No	ClinGen ExAC gnomAD
rs761808392 CA3138226	79	I>L		No	ClinGen ExAC gnomAD
rs761808392 CA3138227	79	I>V		No	ClinGen ExAC gnomAD
CA109958502 rs139927169	82	V>I		No	ClinGen ESP
CA358735889 rs1178903765	90	T>I		No	ClinGen gnomAD
rs572011033 CA3138228	91	I>V		No	ClinGen 1000Genomes ExAC gnomAD
COSM1328602 rs767730345 CA3138230	95	R>Q	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs752979519 CA3138231	99	K>E		No	ClinGen ExAC gnomAD
rs756479262 CA3138232	103	R>K		No	ClinGen ExAC gnomAD
CA358735988 rs1365436406	104	H>R		No	ClinGen TOPMed gnomAD
rs1022851734 CA109958559	104	H>Y		No	ClinGen TOPMed
rs368229029 CA358736000	106	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA3138245 COSM1566864 rs769810828	107	I>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC
CA3138247 rs759602220	111	K>T		No	ClinGen ExAC gnomAD
TCGA novel	113	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358736419 rs1234890652	115	A>P		No	ClinGen TOPMed
rs1315731682 CA358736423	115	A>V		No	ClinGen TOPMed
rs1219530656 CA358736430	116	W>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1277144651 CA358736479	122	L>F		No	ClinGen TOPMed
rs1581251098 CA358736485	123	Y>F		No	ClinGen Ensembl
rs1190935186 CA358736501	125	A>V		No	ClinGen gnomAD
CA109963279 rs200318516	139	S>L		No	ClinGen Ensembl
CA3138272 rs765527443	141	A>S		No	ClinGen ExAC gnomAD
TCGA novel	141	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750938737 CA3138273	141	A>V		No	ClinGen ExAC gnomAD
TCGA novel	144	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1399824324 CA358736664	150	A>T		No	ClinGen TOPMed
CA109964153 rs1011368029	150	A>V		No	ClinGen TOPMed
CA109964155 rs1020526305	151	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	152	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1344678532 CA358736697	154	T>I		No	ClinGen gnomAD
rs371498763 CA3138276	154	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1581252557 CA358736708	156	L>V		No	ClinGen Ensembl
CA358736724 rs1259824647	158	E>G		No	ClinGen gnomAD
rs780765011 CA3138278	160	I>V		No	ClinGen ExAC
CA358736762 rs1181522203	164	A>T		No	ClinGen gnomAD
rs755931467 CA3138280	164	A>V		No	ClinGen ExAC TOPMed gnomAD
CA109964194 rs74366331	169	H>L		No	ClinGen Ensembl
rs771029683 CA3138283	170	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs953473166 CA109964204	172	C>S		No	ClinGen TOPMed
rs1465317171 CA358736859	173	C>Y		No	ClinGen gnomAD
rs774456990 CA3138284	175	G>V		No	ClinGen ExAC gnomAD
rs61731290 CA109964232	180	T>R		No	ClinGen Ensembl
rs1581252678 CA358736970	182	E>G		No	ClinGen Ensembl
rs1348012857 CA358737004	185	D>V		No	ClinGen gnomAD
CA358737051 rs1277130315	189	Q>*		No	ClinGen TOPMed
CA3138285 rs747033096	189	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1016259360 CA109964244	192	T>A		No	ClinGen TOPMed
TCGA novel	192	T>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	197	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762010145 CA3138288	198	I>V		No	ClinGen ExAC gnomAD
rs376136772 CA3138289	200	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1328448899 CA358737228	207	Y>D		No	ClinGen TOPMed gnomAD
rs774833339 CA3138310	212	I>L		No	ClinGen ExAC gnomAD
CA358737284 rs1287533439	214	Y>F		No	ClinGen gnomAD
rs766991448 CA3138312	215	I>V		No	ClinGen ExAC gnomAD
rs955680174 CA109965130	216	F>S		No	ClinGen TOPMed
CA358737303 rs1226592441	217	W>R		No	ClinGen TOPMed gnomAD
rs752184994 CA3138313	224	L>V		No	ClinGen ExAC gnomAD
CA3138314 rs760259652	225	A>S		No	ClinGen ExAC gnomAD
CA3138316 rs753538599	230	K>R		No	ClinGen ExAC gnomAD
TCGA novel	231	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	231	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1207853975 CA358737430	236	A>T		No	ClinGen gnomAD
CA3138319 rs750376977	242	P>L		No	ClinGen ExAC TOPMed gnomAD
rs750376977 CA358737471	242	P>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	253	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1465065302 CA358737565	254	R>K		No	ClinGen TOPMed
rs1019611361 CA109966247	257	L>V		No	ClinGen TOPMed
TCGA novel	259	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358737609 rs1218714279	260	W>L		No	ClinGen TOPMed
CA358737633 COSM1053184 rs1349874515	263	M>I	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
TCGA novel	269	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1451554958 CA358737691	269	L>S		No	ClinGen TOPMed
rs749489517 CA3138343	272	A>T		No	ClinGen ExAC gnomAD
CA358737719 rs1279402323	272	A>V		No	ClinGen gnomAD
CA358737746 rs1212665249	275	S>P		No	ClinGen gnomAD
CA358737926 rs772496354	287	H>P		No	ClinGen ExAC TOPMed gnomAD
CA3138347 rs772496354	287	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1560862182 CA358737949	289	A>S		No	ClinGen Ensembl
rs775791470 CA3138348	289	A>V		No	ClinGen ExAC gnomAD
rs761314451 CA3138349	292	C>G		No	ClinGen ExAC gnomAD
rs1406868937 CA358738005	293	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs866188903 CA109966327	296	F>L		No	ClinGen Ensembl
CA3138351 rs776334285	299	L>F		No	ClinGen ExAC gnomAD
rs761530088 CA3138352	299	L>P		No	ClinGen ExAC gnomAD
rs773021475 CA3138354	301	P>L		No	ClinGen ExAC gnomAD
TCGA novel	301	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA109966373 rs920055186	304	S>N		No	ClinGen TOPMed gnomAD
CA358738197 rs1302413324	305	T>K		No	ClinGen gnomAD
CA358738216 rs766201822	306	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1236240878 CA358738222 COSM3428331	307	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA358738244 rs1338388515	308	A>D		No	ClinGen gnomAD
CA358738238 rs1303631952	308	A>T		No	ClinGen gnomAD
rs1214682822 CA358738882	317	A>S		No	ClinGen gnomAD
rs1581260453 CA358738914	322	V>G		No	ClinGen Ensembl
rs759279829 CA3138376	322	V>I		No	ClinGen ExAC gnomAD
CA358738947 rs1445496556	328	A>T		No	ClinGen gnomAD
CA358738960 rs1195518037	330	I>V		No	ClinGen gnomAD
CA358738982 rs1581260464	333	V>G		No	ClinGen Ensembl
CA358739040 rs1581262275	340	V>F		No	ClinGen Ensembl
rs950652760 CA109969388	342	Y>S		No	ClinGen TOPMed
rs759313953 CA3138400	345	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA3138401 rs771855891	346	L>F		No	ClinGen ExAC gnomAD
rs1179113077 CA358739123	352	S>T		No	ClinGen gnomAD
rs1188097023	355	A>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1363179242 CA358739147	355	A>S		No	ClinGen gnomAD
CA358739150 rs1451307324	355	A>V		No	ClinGen gnomAD
CA358739152 rs1160127147	356	A>S		No	ClinGen gnomAD
rs1385198933 CA358739156	356	A>V		No	ClinGen gnomAD
rs1310539972 CA358739163	357	L>F		No	ClinGen gnomAD
CA358739164 rs1376676265	358	V>L		No	ClinGen gnomAD
rs199652837 CA3138403	360	A>G		No	ClinGen ExAC gnomAD
rs1334546592 CA358739181	361	F>V		No	ClinGen gnomAD
CA3138405 rs750560352	362	V>F		No	ClinGen ExAC gnomAD
rs201934171 CA3138406	363	L>F		No	ClinGen ExAC gnomAD
rs1195330377 CA358739253	371	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA358739266 COSM1201283 rs1249693885	373	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA3138410 rs138459789	373	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1292976144 CA358739270	374	L>V		No	ClinGen TOPMed
CA109969459 rs990938444	376	L>V		No	ClinGen TOPMed
rs1411112290 CA358739337	384	P>A		No	ClinGen gnomAD
TCGA novel	384	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	388	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	388	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748783063 CA358739394	391	F>L		No	ClinGen ExAC gnomAD
CA109969490 rs375181512	392	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
CA358739412 rs1434761944	394	I>T		No	ClinGen gnomAD
CA3138416 rs770356259	396	L>I		No	ClinGen ExAC TOPMed gnomAD
CA3138417 rs778557557	398	V>I		No	ClinGen ExAC gnomAD
CA109969507 rs199942294	404	G>*		No	ClinGen 1000Genomes
TCGA novel	404	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	404	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1264658684 CA358739479	405	A>G		No	ClinGen TOPMed
TCGA novel	405	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1370640886 CA358739494	407	F>S		No	ClinGen gnomAD
rs267600078 CA109969521	409	R>S		No	ClinGen Ensembl
CA358739506 rs1232578431	409	R>W		No	ClinGen gnomAD
rs745571413 CA3138418	410	A>P		No	ClinGen ExAC gnomAD
CA358739556 rs1226755983	416	R>C		No	ClinGen gnomAD
rs532326953 COSM1053187 CA3138420	416	R>H	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA3138421 rs775316167	417	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA358739566 rs1197415780	418	R>H		No	ClinGen gnomAD
rs550251699 CA3138422	421	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs768544158 CA3138423	423	F>L		No	ClinGen ExAC gnomAD
CA109969612 rs1009032775	428	V>I		No	ClinGen TOPMed
CA3138426 rs766374464	429	L>V		No	ClinGen ExAC TOPMed gnomAD
CA358739656 rs1560865650	432	I>V		No	ClinGen Ensembl
rs1427706224 CA358739666	433	I>T		No	ClinGen gnomAD
CA3138427 rs202171550	434	V>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1171946572 CA358739675	435	A>P		No	ClinGen gnomAD
rs201222028 CA3138428	435	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1439120361 CA358739679	436	A>T		No	ClinGen gnomAD
rs200247470 CA109969619	437	I>V		No	ClinGen 1000Genomes
CA3138429 rs767961312	439	A>G		No	ClinGen ExAC
rs756569280 CA3138431	441	I>V		No	ClinGen ExAC gnomAD
rs1381933577 CA358739736	445	N>D		No	ClinGen gnomAD
CA358739743 rs1395544199	446	P>A		No	ClinGen TOPMed
rs1560865745 CA358739758	448	T>S		No	ClinGen Ensembl
CA3138432 rs201828746	450	L>V		No	ClinGen 1000Genomes ExAC gnomAD
CA109969700 rs201059509	453	S>G		No	ClinGen 1000Genomes
rs1211568889 CA358739803	455	L>Q		No	ClinGen gnomAD
rs375092988 CA3138436	455	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs745499710 CA3138437	456	I>T		No	ClinGen ExAC gnomAD
CA358739813 rs1488685516	457	K>E		No	ClinGen gnomAD
CA3138438 rs771755603	459	L>F		No	ClinGen ExAC gnomAD
CA358739832 rs1259256487	459	L>R		No	ClinGen gnomAD
rs1429730307 CA358739863	464	G>S		No	ClinGen gnomAD
rs1382303808 CA358739872	465	P>H		No	ClinGen TOPMed gnomAD
CA358739871 rs1170820199	465	P>T		No	ClinGen TOPMed gnomAD
CA358739919 rs1167546531	472	C>W		No	ClinGen gnomAD
CA3138441 rs535022367	476	N>S		No	ClinGen 1000Genomes ExAC gnomAD
CA358739952 rs1177334780	477	D>Y		No	ClinGen TOPMed
TCGA novel	480	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3138442 rs776565829	481	S>G		No	ClinGen ExAC gnomAD
CA3138443 rs748101747	481	S>N		No	ClinGen ExAC gnomAD
rs1400661836 CA358739992	482	K>R		No	ClinGen gnomAD
CA358739999 rs1292805255	483	I>T		No	ClinGen gnomAD
TCGA novel	484	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3138444 rs771031315	484	V>I		No	ClinGen ExAC gnomAD
rs1322046061 CA358740007	485	D>N		No	ClinGen TOPMed gnomAD
TCGA novel	486	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3138446 rs139779279	487	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA109969756 rs143120417	490	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA
CA3138447 rs553052405	490	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA358740046 rs553052405	490	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1482475586 CA358740063	493	G>D		No	ClinGen TOPMed
rs761049815 CA3138449	494	I>F		No	ClinGen ExAC TOPMed gnomAD
CA3138450 rs764429156	494	I>T		No	ClinGen ExAC gnomAD
TCGA novel	495	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	497	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3138451 rs754354048	498	S>L		No	ClinGen ExAC gnomAD
CA3138453 rs764776707	500	I>L		No	ClinGen ExAC gnomAD
CA358740114 rs1418824643	500	I>M		No	ClinGen TOPMed gnomAD
rs764776707 CA3138454	500	I>V		No	ClinGen ExAC gnomAD
TCGA novel	501	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1157430574 CA358740148	502	Q>L		No	ClinGen gnomAD
rs1034994754 CA109969866	506	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	506	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs146667280 CA3138455	508	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs779627892 CA358740251	511	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1581263269 CA358740265	512	I>V		No	ClinGen Ensembl
rs746670020 CA3138457	513	M>V		No	ClinGen ExAC gnomAD
CA3138458 rs754799105	515	V>I		No	ClinGen ExAC gnomAD
rs1392984486 CA358740340	516	F>L		No	ClinGen TOPMed
CA3138459 rs568458140	518	F>S		No	ClinGen 1000Genomes ExAC gnomAD
CA358737755 rs1425661952	522	V>I		No	ClinGen gnomAD
rs776936947 CA3138495	533	I>T		No	ClinGen ExAC TOPMed gnomAD
CA3138494 rs768722953	533	I>V		No	ClinGen ExAC gnomAD
CA3138496 rs762030200	535	A>V		No	ClinGen ExAC gnomAD
CA358738109 rs1192720795	536	I>T		No	ClinGen TOPMed
CA358738119 rs1279604221	537	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
COSM3674134 rs1237224362 CA358738147	538	G>R	prostate [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1198836526 CA358738227	541	V>A		No	ClinGen TOPMed
rs934370424 CA109933884	543	I>F		No	ClinGen TOPMed
rs773704301 CA3138498	544	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs751111899 CA3138501	545	V>M		No	ClinGen ExAC gnomAD
CA358738357 rs1210845188	548	L>V		No	ClinGen gnomAD
CA358738385 rs1313353344	550	Y>F		No	ClinGen TOPMed
CA3138502 rs759105108	550	Y>H		No	ClinGen ExAC gnomAD
rs767015898 CA3138503	551	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1218902825 CA358738414	552	H>R		No	ClinGen gnomAD
CA358738432 rs1474916420	553	H>Q		No	ClinGen TOPMed gnomAD
rs755852057 CA3138505	554	D>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	560	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1163576029 CA358738694	572	G>V		No	ClinGen gnomAD
rs1299648664 CA358738739	576	M>V		No	ClinGen TOPMed gnomAD
rs561414549 CA109933987	578	G>S		No	ClinGen 1000Genomes
rs367548875 CA3138509	579	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs143673320 CA3138510	580	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA109936027 rs973376827	584	G>D		No	ClinGen TOPMed
CA109936028 rs1005836702	585	G>S		No	ClinGen Ensembl
CA358740393 rs1368319618	590	T>A		No	ClinGen TOPMed
rs1324651173 CA358740402	590	T>S		No	ClinGen TOPMed
rs149080175 CA3138532	595	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA358740646 rs1394924170	611	M>T		No	ClinGen gnomAD
CA3138537 rs746440784	612	A>S		No	ClinGen ExAC gnomAD
CA3138538 rs746440784	612	A>T		No	ClinGen ExAC gnomAD
rs1581275755 CA358740674	613	A>G		No	ClinGen Ensembl
rs1172967866 CA358740719	616	T>I		No	ClinGen TOPMed
CA358740781 rs1581275786	620	V>G		No	ClinGen Ensembl
CA358740810 rs1439069322	623	A>T		No	ClinGen gnomAD
rs1303661798 CA358740842	625	G>D		No	ClinGen TOPMed gnomAD
CA358740846 rs1303661798	625	G>V		No	ClinGen TOPMed gnomAD
rs1581275820 CA358740870	627	E>G		No	ClinGen Ensembl
CA3138540 rs760290940	633	H>R		No	ClinGen ExAC gnomAD
CA3138541 rs143157406	634	I>V		No	ClinGen ESP ExAC
COSM171326 CA109936112 rs763040164	635	R>Q	large_intestine Variant assessed as Somatic; 4.62e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1200318733 CA358741047	644	A>T		No	ClinGen gnomAD
CA358741088 rs750318734	646	E>D		No	ClinGen ExAC gnomAD
TCGA novel	647	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358741096 rs1189153280 COSM1053192	647	E>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs949049347 CA109936142	649	T>S		No	ClinGen TOPMed
rs1480268486 CA358741138	650	H>P		No	ClinGen TOPMed
rs1433300940 CA358741135	650	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA358741167 rs1581275975	652	T>P		No	ClinGen Ensembl
CA3138547 rs199772997	653	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs544550257 CA109936170	654	A>S		No	ClinGen 1000Genomes
rs1422129392 CA358741197	655	A>T		No	ClinGen gnomAD
rs1467583867 CA358741204	655	A>V		No	ClinGen gnomAD
CA3138549 rs751365665	657	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1269700482 CA358741241	658	M>T		No	ClinGen gnomAD
rs1053599827 CA109936180	660	P>L		No	ClinGen TOPMed
rs981035966 CA109936185	661	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	662	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3138550 rs777901937	663	N>S		No	ClinGen ExAC gnomAD
rs893619654 CA109936188	664	D>G		No	ClinGen TOPMed
rs749575147 CA3138551	665	P>A		No	ClinGen ExAC gnomAD
CA3138552 rs757600494	666	P>S		No	ClinGen ExAC gnomAD
CA109936227 rs113417368	669	V>L		No	ClinGen Ensembl
TCGA novel	672	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746329223 CA3138554	673	D>N		No	ClinGen ExAC TOPMed gnomAD
CA358741374 rs1338340614	674	N>H		No	ClinGen gnomAD
rs756899030 CA3138555	675	M>R		No	ClinGen ExAC gnomAD
rs1020872770 CA109936254	675	M>V		No	ClinGen TOPMed
CA358741464 rs1267750566	680	I>V		No	ClinGen gnomAD
CA109936272 rs369710099	683	M>T		No	ClinGen ESP TOPMed gnomAD
rs746462649 CA3138557	685	N>H		No	ClinGen ExAC gnomAD
rs1197219101 CA358741550	685	N>K		No	ClinGen gnomAD
CA109936289 rs866989531	687	T>N		No	ClinGen Ensembl
CA3138558 rs768288344	688	S>G		No	ClinGen ExAC gnomAD
CA358741721 rs1174554979	698	K>E		No	ClinGen TOPMed
CA109936302 rs576336377	698	K>R		No	ClinGen Ensembl
rs776419289 CA3138559	699	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
TCGA novel	708	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1211249183 CA358741807	709	R>G		No	ClinGen Ensembl
rs1362205071 CA358741809	709	R>K		No	ClinGen TOPMed
rs1379685332 CA358742159	717	E>D		No	ClinGen gnomAD
rs1445735089 CA358742162	718	S>G		No	ClinGen gnomAD
CA358742185 rs1355347360	721	K>R		No	ClinGen gnomAD
CA358742194 rs1240256113	722	K>R		No	ClinGen gnomAD
TCGA novel	723	Q>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358742213 rs1278905593	725	G>S		No	ClinGen gnomAD
CA3138588 rs761819807	726	I>N		No	ClinGen ExAC gnomAD
CA3138587 rs753874205	726	I>V		No	ClinGen ExAC gnomAD
CA109940326 rs971407708	727	V>A		No	ClinGen Ensembl
CA3138590 rs145822355	727	V>I		No	ClinGen 1000Genomes ExAC gnomAD
rs1177114072 CA358742234	729	S>G		No	ClinGen gnomAD
CA3138591 rs758786674	731	R>L		No	ClinGen ExAC TOPMed gnomAD
rs758786674 CA358742250	731	R>P		No	ClinGen ExAC TOPMed gnomAD
CA109940345 rs758786674	731	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA358742264 rs1239714545	733	C>W		No	ClinGen TOPMed
rs927567749 CA109940347	735	A>V		No	ClinGen gnomAD
TCGA novel	737	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3138595 rs147028755	738	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA358742304 rs1464928963	739	P>L		No	ClinGen TOPMed gnomAD
rs1359632160 CA358742301	739	P>S		No	ClinGen gnomAD
CA109940363 rs901491111	740	S>P		No	ClinGen TOPMed
CA3138597 rs769203426	741	L>V		No	ClinGen ExAC TOPMed gnomAD
CA358742385 rs1447149355	747	R>Q		No	ClinGen gnomAD
CA358742406 rs1581286514	748	P>Q		No	ClinGen Ensembl
CA3138598 rs201904904	752	R>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA358742457 rs1409025280	752	R>Q		No	ClinGen Ensembl
rs767634480 CA109940385	758	S>R		No	ClinGen Ensembl
CA358742609 rs1241421595	761	T>A		No	ClinGen TOPMed
CA358742644 rs1220421279	763	T>I		No	ClinGen gnomAD
RCV000417121 rs770732784 CA3138600	768	M>V		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs1458487009 CA358742812	771	V>M		No	ClinGen gnomAD
CA358742853 rs1193297569	773	D>N		No	ClinGen gnomAD
CA3138602 rs759355995	775	F>S		No	ClinGen ExAC gnomAD
CA358742944 rs1479067247	776	R>Q		No	ClinGen TOPMed gnomAD
CA358743076 rs1418525094	782	Q>R		No	ClinGen gnomAD
CA3138606 rs765303593	788	N>S		No	ClinGen ExAC TOPMed gnomAD
rs199740610 CA109944529	790	R>C		No	ClinGen gnomAD
CA358746808 rs771142045	790	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs771142045 CA3138648	790	R>L		No	ClinGen ExAC gnomAD
rs955867200 CA109944533	800	I>T		No	ClinGen Ensembl
rs370753183 CA3138650	800	I>V		No	ClinGen ESP ExAC gnomAD
rs772530201 CA3138652	802	R>Q		No	ClinGen ExAC gnomAD
rs372151295 CA3138655	807	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA358747397 rs1415421656	808	A>S		No	ClinGen gnomAD
rs761305953 CA3138657	812	P>S		No	ClinGen ExAC gnomAD
rs556864442 CA3138659	813	A>T		No	ClinGen ExAC TOPMed gnomAD
rs201683703 CA3138660	815	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1231114163 CA358747678	816	M>V		No	ClinGen gnomAD

2 associated diseases with P51790

[MIM: 619512]: Neurodevelopmental disorder with hypotonia and brain abnormalities (NEDHYBA)

An autosomal dominant disorder characterized by onset in infancy or early childhood, global developmental delay, hypotonia, impaired intellectual development, and poor or absent speech. Additional variable manifestations may be present, including feeding difficulties, seizures, behavioral abnormalities, and non-specific dysmorphic facial features. Brain imaging shows variable abnormalities, including corpus callosum and cerebellar defects, and decreased white matter volume. {ECO:0000269|PubMed:34186028}. Note=The disease is caused by variants affecting the gene represented in this entry.

[MIM: 619517]: Neurodevelopmental disorder with seizures and brain abnormalities (NEDSBA)

An autosomal recessive neurologic disorder characterized by global developmental delay and onset of seizures in the first months of life, and structural brain defects on brain imaging. Additional features may include pigmentary retinopathy with poor visual fixation and spasticity. {ECO:0000269|PubMed:34186028}. Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID

An autosomal dominant disorder characterized by onset in infancy or early childhood, global developmental delay, hypotonia, impaired intellectual development, and poor or absent speech. Additional variable manifestations may be present, including feeding difficulties, seizures, behavioral abnormalities, and non-specific dysmorphic facial features. Brain imaging shows variable abnormalities, including corpus callosum and cerebellar defects, and decreased white matter volume. {ECO:0000269|PubMed:34186028}. Note=The disease is caused by variants affecting the gene represented in this entry.
An autosomal recessive neurologic disorder characterized by global developmental delay and onset of seizures in the first months of life, and structural brain defects on brain imaging. Additional features may include pigmentary retinopathy with poor visual fixation and spasticity. {ECO:0000269|PubMed:34186028}. Note=The disease is caused by variants affecting the gene represented in this entry.

3 regional properties for P51790

Type	Name	Position	InterPro Accession
domain	Neurotransmitter-gated ion-channel transmembrane domain	252 - 479	IPR006029
domain	Neurotransmitter-gated ion-channel ligand-binding domain	31 - 245	IPR006202
conserved_site	Neurotransmitter-gated ion-channel, conserved site	154 - 168	IPR018000

Functions

		Description
EC Number
Subcellular Localization	[Isoform 1]: Early endosome membrane ; Multi-pass membrane protein Late endosome membrane ; Multi-pass membrane protein Lysosome membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein	Isoform 1 is localized mainly in late endosomes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

30 GO annotations of cellular component

Name	Definition
apical plasma membrane	The region of the plasma membrane located at the apical end of the cell.
axon terminus	Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
cell surface	The external part of the cell wall and/or plasma membrane.
cytoplasmic vesicle	A vesicle found in the cytoplasm of a cell.
early endosome	A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
early endosome membrane	The lipid bilayer surrounding an early endosome.
endosome membrane	The lipid bilayer surrounding an endosome.
external side of plasma membrane	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
GABA-ergic synapse	A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
inhibitory synapse	A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of postsynaptic membrane	The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of synaptic vesicle membrane	The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
late endosome	A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
late endosome membrane	The lipid bilayer surrounding a late endosome.
lysosomal membrane	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
phagocytic vesicle	A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
recycling endosome	An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
ruffle membrane	The portion of the plasma membrane surrounding a ruffle.
secretory granule	A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
specific granule	Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
synaptic vesicle	A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
vesicle membrane	The lipid bilayer surrounding any membrane-bounded vesicle in the cell.

7 GO annotations of molecular function

Name	Definition
antiporter activity	Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
chloride channel activity	Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
PDZ domain binding	Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.
solute:proton antiporter activity	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out).
voltage-gated chloride channel activity	Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
volume-sensitive chloride channel activity	Enables the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell.

11 GO annotations of biological process

Name	Definition
adult locomotory behavior	Locomotory behavior in a fully developed and mature organism.
chloride transmembrane transport	The process in which chloride is transported across a membrane.
endosomal lumen acidification	Any process that reduces the pH of the endosomal lumen, measured by the concentration of the hydrogen ion.
negative regulation of cell volume	Any process that decreases cell volume.
phagocytosis, engulfment	The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
photoreceptor cell maintenance	Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light.
positive regulation of reactive oxygen species biosynthetic process	Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process.
regulation of pH	Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell.
synaptic transmission, GABAergic	The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
synaptic transmission, glutamatergic	The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
synaptic vesicle lumen acidification	The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading.

9 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P37020	GEF1	Anion/proton exchange transporter GEF1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P51797	CLCN6	H(+)/Cl(-) exchange transporter 6	Homo sapiens (Human)	PR
P51798	CLCN7	H(+)/Cl(-) exchange transporter 7	Homo sapiens (Human)	PR
O70496	Clcn7	H(+)/Cl(-) exchange transporter 7	Mus musculus (Mouse)	PR
Q61418	Clcn4	H(+)/Cl(-) exchange transporter 4	Mus musculus (Mouse)	PR
P51791	Clcn3	H(+)/Cl(-) exchange transporter 3	Mus musculus (Mouse)	PR
P51799	Clcn7	H(+)/Cl(-) exchange transporter 7	Rattus norvegicus (Rat)	PR
P51792	Clcn3	H(+)/Cl(-) exchange transporter 3	Rattus norvegicus (Rat)	PR
P60300	CLC-G	Putative chloride channel-like protein CLC-g	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MESEQLFHRG	YYRNSYNSIT	SASSDEELLD	GAGVIMDFQT	SEDDNLLDGD	TAVGTHYTMT
70	80	90	100	110	120
NGGSINSSTH	LLDLLDEPIP	GVGTYDDFHT	IDWVREKCKD	RERHRRINSK	KKESAWEMTK
130	140	150	160	170	180
SLYDAWSGWL	VVTLTGLASG	ALAGLIDIAA	DWMTDLKEGI	CLSALWYNHE	QCCWGSNETT
190	200	210	220	230	240
FEERDKCPQW	KTWAELIIGQ	AEGPGSYIMN	YIMYIFWALS	FAFLAVSLVK	VFAPYACGSG
250	260	270	280	290	300
IPEIKTILSG	FIIRGYLGKW	TLMIKTITLV	LAVASGLSLG	KEGPLVHVAC	CCGNIFSYLF
310	320	330	340	350	360
PKYSTNEAKK	REVLSAASAA	GVSVAFGAPI	GGVLFSLEEV	SYYFPLKTLW	RSFFAALVAA
370	380	390	400	410	420
FVLRSINPFG	NSRLVLFYVE	YHTPWYLFEL	FPFILLGVFG	GLWGAFFIRA	NIAWCRRRKS
430	440	450	460	470	480
TKFGKYPVLE	VIIVAAITAV	IAFPNPYTRL	NTSELIKELF	TDCGPLESSS	LCDYRNDMNA
490	500	510	520	530	540
SKIVDDIPDR	PAGIGVYSAI	WQLCLALIFK	IIMTVFTFGI	KVPSGLFIPS	MAIGAIAGRI
550	560	570	580	590	600
VGIAVEQLAY	YHHDWFIFKE	WCEVGADCIT	PGLYAMVGAA	ACLGGVTRMT	VSLVVIVFEL
610	620	630	640	650	660
TGGLEYIVPL	MAAVMTSKWV	GDAFGREGIY	EAHIRLNGYP	FLDAKEEFTH	TTLAADVMRP
670	680	690	700	710	720
RRNDPPLAVL	TQDNMTVDDI	ENMINETSYN	GFPVIMSKES	QRLVGFALRR	DLTIAIESAR
730	740	750	760	770	780
KKQEGIVGSS	RVCFAQHTPS	LPAESPRPLK	LRSILDMSPF	TVTDHTPMEI	VVDIFRKLGL
790	800	810
RQCLVTHNGR	LLGIITKKDI	LRHMAQTANQ	DPASIMFN