P60300
PR
Gene name |
CLC-G (CBSCLC6, At5g33280, F19N02.1, T29A4.90) |
Protein name |
Putative chloride channel-like protein CLC-g |
Names |
CBS domain-containing protein CBSCLC6 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G33280 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P60300
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P60300-F1 | Predicted | AlphaFoldDB |
57 variants for P60300
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH11717083 | 10 | V>D | No | 1000Genomes | |
| ENSVATH07166802 | 18 | L>V | No | 1000Genomes | |
| ENSVATH03215362 | 19 | R>C | No | 1000Genomes | |
| tmp_5_12549349_T_G | 24 | S>A | No | 1000Genomes | |
| tmp_5_12549500_C_T | 46 | A>V | No | 1000Genomes | |
| ENSVATH14479467 | 79 | I>T | No | 1000Genomes | |
| ENSVATH07166805 | 102 | V>I | No | 1000Genomes | |
| ENSVATH03215367 | 109 | A>T | No | 1000Genomes | |
| ENSVATH07166810 | 122 | T>I | No | 1000Genomes | |
| ENSVATH11717127 | 125 | I>T | No | 1000Genomes | |
| tmp_5_12549845_T_A | 133 | I>N | No | 1000Genomes | |
| tmp_5_12549916_G_A | 157 | D>N | No | 1000Genomes | |
| tmp_5_12549920_C_G | 158 | A>G | No | 1000Genomes | |
| ENSVATH07166811 | 164 | L>F | No | 1000Genomes | |
| tmp_5_12550066_A_T | 175 | I>L | No | 1000Genomes | |
| ENSVATH14479471 | 177 | A>T | No | 1000Genomes | |
| tmp_5_12550114_G_A | 191 | V>M | No | 1000Genomes | |
| ENSVATH07166813 | 233 | A>T | No | 1000Genomes | |
| tmp_5_12550267_C_G | 242 | R>G | No | 1000Genomes | |
| ENSVATH07166818 | 260 | R>S | No | 1000Genomes | |
| ENSVATH07166819 | 261 | S>G | No | 1000Genomes | |
| ENSVATH07166820 | 261 | S>T | No | 1000Genomes | |
| tmp_5_12550492_T_A | 274 | V>E | No | 1000Genomes | |
| ENSVATH00668415 | 347 | Y>H | No | 1000Genomes | |
| ENSVATH03215386 | 349 | K>* | No | 1000Genomes | |
| ENSVATH03215387 | 349 | K>I | No | 1000Genomes | |
| tmp_5_12550800_T_A | 353 | W>R | No | 1000Genomes | |
| ENSVATH14479474 | 357 | L>V | No | 1000Genomes | |
| ENSVATH03215388 | 358 | A>G | No | 1000Genomes | |
| tmp_5_12550861_C_T | 373 | P>L | No | 1000Genomes | |
| ENSVATH14479495 | 393 | G>E | No | 1000Genomes | |
| tmp_5_12550948_A_G | 402 | Q>R | No | 1000Genomes | |
| tmp_5_12550969_A_G | 409 | N>S | No | 1000Genomes | |
| ENSVATH07166825 | 415 | I>V | No | 1000Genomes | |
| ENSVATH14479496 | 422 | A>T | No | 1000Genomes | |
| ENSVATH11717131 | 423 | I>V | No | 1000Genomes | |
| ENSVATH07166826 | 424 | K>N | No | 1000Genomes | |
| tmp_5_12551055_T_G | 438 | F>V | No | 1000Genomes | |
| ENSVATH11717132 | 478 | V>L | No | 1000Genomes | |
| ENSVATH11717133 | 481 | L>V | No | 1000Genomes | |
| tmp_5_12551190_G_A | 483 | G>S | No | 1000Genomes | |
| tmp_5_12551226_G_C | 495 | V>L | No | 1000Genomes | |
| tmp_5_12551475_A_G | 578 | T>A | No | 1000Genomes | |
| ENSVATH14479498 | 603 | N>D | No | 1000Genomes | |
| tmp_5_12551592_C_T | 617 | P>S | No | 1000Genomes | |
| ENSVATH00668428 | 626 | A>P | No | 1000Genomes | |
| ENSVATH11717134 | 640 | S>C | No | 1000Genomes | |
| ENSVATH03215390 | 650 | S>A | No | 1000Genomes | |
| ENSVATH03215390 | 650 | S>T | No | 1000Genomes | |
| ENSVATH03215391 | 652 | F>L | No | 1000Genomes | |
| tmp_5_12551759_A_C | 672 | E>D | No | 1000Genomes | |
| ENSVATH07166828 | 722 | T>N | No | 1000Genomes | |
| tmp_5_12552181_G_C | 725 | R>T | No | 1000Genomes | |
| tmp_5_12552186_C_T | 727 | P>S | No | 1000Genomes | |
| ENSVATH11717221 | 739 | P>L | No | 1000Genomes | |
| ENSVATH07166829 | 760 | R>W | No | 1000Genomes | |
| ENSVATH00668436 | 764 | F>L | No | 1000Genomes |
No associated diseases with P60300
1 regional properties for P60300
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | CBS domain | 687 - 748 | IPR000644 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloride channel complex | An ion channel complex through which chloride ions pass. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| plant-type vacuole membrane | The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| chloride transmembrane transporter activity | Enables the transfer of chloride ions from one side of a membrane to the other. |
| voltage-gated chloride channel activity | Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P51790 | CLCN3 | H(+)/Cl(-) exchange transporter 3 | Homo sapiens (Human) | PR |
| P51798 | CLCN7 | H(+)/Cl(-) exchange transporter 7 | Homo sapiens (Human) | PR |
| P51797 | CLCN6 | H(+)/Cl(-) exchange transporter 6 | Homo sapiens (Human) | PR |
| O70496 | Clcn7 | H(+)/Cl(-) exchange transporter 7 | Mus musculus (Mouse) | PR |
| Q61418 | Clcn4 | H(+)/Cl(-) exchange transporter 4 | Mus musculus (Mouse) | PR |
| O35454 | Clcn6 | H(+)/Cl(-) exchange transporter 6 | Mus musculus (Mouse) | PR |
| P51799 | Clcn7 | H(+)/Cl(-) exchange transporter 7 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPNSTTEDSV | AVPLLPSLRR | ATNSTSQVAI | VGANVCPIES | LDYEIAENDF | FKQDWRGRSK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VEIFQYVFMK | WLLCFCIGII | VSLIGFANNL | AVENLAGVKF | VVTSNMMIAG | RFAMGFVVFS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VTNLILTLFA | SVITAFVAPA | AAGSGIPEVK | AYLNGVDAPE | IFSLRTLIIK | IIGNISAVSA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SLLIGKAGPM | VHTGACVASI | LGQGGSKRYR | LTWRWLRFFK | NDRDRRDLVT | CGAAAGIAAS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FRAPVGGVLF | ALEEMSSWWR | SALLWRIFFS | TAVVAIVLRA | LIDVCLSGKC | GLFGKGGLIM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FDVYSENASY | HLGDVLPVLL | LGVVGGILGS | LYNFLLDKVL | RAYNYIYEKG | VTWKILLACA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ISIFTSCLLF | GLPFLASCQP | CPVDALEECP | TIGRSGNFKK | YQCPPGHYND | LASLIFNTND |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DAIKNLFSKN | TDFEFHYFSV | LVFFVTCFFL | SIFSYGIVAP | AGLFVPVIVT | GASYGRFVGM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LLGSNSNLNH | GLFAVLGAAS | FLGGTMRMTV | STCVILLELT | NNLLLLPMMM | VVLLISKTVA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DGFNANIYNL | IMKLKGFPYL | YSHAEPYMRQ | LLVGDVVTGP | LQVFNGIEKV | ETIVHVLKTT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NHNGFPVVDG | PPLAAAPVLH | GLILRAHILT | LLKKRVFMPS | PVACDSNTLS | QFKAEEFAKK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GSGRSDKIED | VELSEEELNM | YLDLHPFSNA | SPYTVVETMS | LAKALILFRE | VGIRHLLVIP |
| 730 | 740 | 750 | 760 | ||
| KTSNRPPVVG | ILTRHDFMPE | HILGLHPSVS | RSKWKRLRIR | LPFFS |