AiPD: Autoinhibited Protein Database

Gene name	Clcn6
Protein name	H(+)/Cl(-) exchange transporter 6
Names	Chloride channel protein 6, ClC-6, Chloride transport protein 6
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:26372
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-69 (Predicted disordered autoinhibitory region) PR

1-69 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O35454-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388733474	13	R>Q	No	EVA
rs3388717686	33	G>R	No	EVA
rs3388725762	51	L>P	No	EVA
rs3388733458	145	S>C	No	EVA
rs3388730689	149	L>*	No	EVA
rs3388725725	164	C>Y	No	EVA
rs3388735509	186	G>W	No	EVA
rs3388730206	205	H>Y	No	EVA
rs3388717717	223	R>W	No	EVA
rs3388725768	237	D>E	No	EVA
rs3388731764	306	F>Y	No	EVA
rs3388731809	337	F>L	No	EVA
rs3388726165	363	M>I	No	EVA
rs3388733477	375	V>I	No	EVA
rs3388733203	387	V>M	No	EVA
rs3388737532	423	N>Y	No	EVA
rs3388730146	438	D>N	No	EVA
rs3388730190	441	T>I	No	EVA
rs3388731782	488	G>D	No	EVA
rs3388706377	497	G>*	No	EVA
rs3388725793	563	M>T	No	EVA
rs3388728181	570	D>Y	No	EVA
rs3388730201	579	V>I	No	EVA
rs3388733206	610	L>Q	No	EVA
rs3388733423	613	V>I	No	EVA
rs3388733392	617	T>I	No	EVA
rs3388730193	617	T>S	No	EVA
rs3388725759	622	L>R	No	EVA
rs3388719996	631	H>R	No	EVA
rs3388737527	682	Y>*	No	EVA
rs3395091051	756	V>D	No	EVA
rs3388731791	775	Y>*	No	EVA
rs3388720018	780	E>D	No	EVA
rs3388726161	825	F>L	No	EVA
rs3388733204	829	R>I	No	EVA
rs3388735459	853	N>I	No	EVA
rs3388720019	860	Q>H	No	EVA

Type	Name	Position	InterPro Accession
domain	CBS domain	602 - 658	IPR000644-1
domain	CBS domain	807 - 869	IPR000644-2

		Description
EC Number
Subcellular Localization	Late endosome membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
late endosome membrane	The lipid bilayer surrounding a late endosome.

Name	Definition
antiporter activity	Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
chloride transmembrane transporter activity	Enables the transfer of chloride ions from one side of a membrane to the other.
voltage-gated chloride channel activity	Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

Name	Definition
chloride transport	The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
response to mechanical stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P51798	CLCN7	H(+)/Cl(-) exchange transporter 7	Homo sapiens (Human)	PR
P51797	CLCN6	H(+)/Cl(-) exchange transporter 6	Homo sapiens (Human)	PR
O70496	Clcn7	H(+)/Cl(-) exchange transporter 7	Mus musculus (Mouse)	PR
P51799	Clcn7	H(+)/Cl(-) exchange transporter 7	Rattus norvegicus (Rat)	PR
P60300	CLC-G	Putative chloride channel-like protein CLC-g	Arabidopsis thaliana (Mouse-ear cress)	PR