AiPD: Autoinhibited Protein Database

Gene name	Clcn7
Protein name	H(+)/Cl(-) exchange transporter 7
Names	Chloride channel 7 alpha subunit, Chloride channel protein 7, ClC-7
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:26373
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-73 (Predicted disordered autoinhibitory region) PR

1-73 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O70496-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389459499	71	V>D	No	EVA
rs3389440770	91	K>N	No	EVA
rs3389435412	120	V>G	No	EVA
rs3389453961	121	E>V	No	EVA
rs3389436631	139	A>V	No	EVA
rs3389403432	144	I>F	No	EVA
rs3389355735	150	A>V	No	EVA
rs3407590533	168	G>D	No	EVA
rs3407455052	177	W>*	No	EVA
rs3407439554	180	L>M	No	EVA
rs3389391222	186	L>F	No	EVA
rs3389432954	189	S>P	No	EVA
rs3389459530	193	A>P	No	EVA
rs1132505167	258	G>E	No	EVA
rs1133632944	260	S>*	No	EVA
rs1132833031	260	S>P	No	EVA
rs1132579765	265	T>A	No	EVA
rs3389449827	265	T>I	No	EVA
rs3389421430	301	A>V	No	EVA
rs3389445566	341	S>N	No	EVA
rs3389432976	363	S>*	No	EVA
rs3389442190	381	V>M	No	EVA
rs1134635052	392	A>V	No	EVA
rs3389445582	404	Y>H	No	EVA
rs3389436555	405	I>F	No	EVA
rs3389459481	411	Q>P	No	EVA
rs3389443366	413	I>N	No	EVA
rs3389412034	423	A>V	No	EVA
rs3389453919	454	D>E	No	EVA
rs3389403400	485	P>S	No	EVA
rs3389449795	488	L>H	No	EVA
rs3389440710	496	F>L	No	EVA
rs3389403404	554	L>H	No	EVA
rs3406597387	565	T>A	No	EVA
rs3389445599	573	S>I	No	EVA
rs3389435453	659	F>L	No	EVA
rs3389435430	672	R>K	No	EVA
rs3389436589	683	I>N	No	EVA
rs3407501434	693	E>K	No	EVA
rs3389391286	726	Q>P	No	EVA
rs3389440729	727	D>V	No	EVA
rs3389443358	735	L>R	No	EVA
rs3405722371	748	Q>L	No	EVA
rs3389421444	797	E>K	No	EVA

Type	Name	Position	InterPro Accession
domain	CBS domain	625 - 687	IPR000644-1
domain	CBS domain	736 - 797	IPR000644-2

		Description
EC Number
Subcellular Localization	Lysosome membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chloride channel complex	An ion channel complex through which chloride ions pass.
cytoplasmic vesicle	A vesicle found in the cytoplasm of a cell.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
lysosomal membrane	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.

Name	Definition
antiporter activity	Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
chloride transmembrane transporter activity	Enables the transfer of chloride ions from one side of a membrane to the other.
voltage-gated chloride channel activity	Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

Name	Definition
response to pH	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
transepithelial chloride transport	The directed movement of chloride ions from one side of an epithelium to the other.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P51790	CLCN3	H(+)/Cl(-) exchange transporter 3	Homo sapiens (Human)	PR
P51797	CLCN6	H(+)/Cl(-) exchange transporter 6	Homo sapiens (Human)	PR
P51798	CLCN7	H(+)/Cl(-) exchange transporter 7	Homo sapiens (Human)	PR
Q61418	Clcn4	H(+)/Cl(-) exchange transporter 4	Mus musculus (Mouse)	PR
O35454	Clcn6	H(+)/Cl(-) exchange transporter 6	Mus musculus (Mouse)	PR
P51799	Clcn7	H(+)/Cl(-) exchange transporter 7	Rattus norvegicus (Rat)	PR
P60300	CLC-G	Putative chloride channel-like protein CLC-g	Arabidopsis thaliana (Mouse-ear cress)	PR