P51799
Gene name |
Clcn7 |
Protein name |
H(+)/Cl(-) exchange transporter 7 |
Names |
Chloride channel 7 alpha subunit, Chloride channel protein 7, ClC-7 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:29233 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P51799
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P51799-F1 | Predicted | AlphaFoldDB |
No variants for P51799
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P51799 | |||||
No associated diseases with P51799
2 regional properties for P51799
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | CBS domain | 625 - 687 | IPR000644-1 |
| domain | CBS domain | 736 - 797 | IPR000644-2 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloride channel complex | An ion channel complex through which chloride ions pass. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| antiporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| chloride transmembrane transporter activity | Enables the transfer of chloride ions from one side of a membrane to the other. |
| voltage-gated chloride channel activity | Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| response to pH | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. |
| transepithelial chloride transport | The directed movement of chloride ions from one side of an epithelium to the other. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P51790 | CLCN3 | H(+)/Cl(-) exchange transporter 3 | Homo sapiens (Human) | PR |
| P51797 | CLCN6 | H(+)/Cl(-) exchange transporter 6 | Homo sapiens (Human) | PR |
| P51798 | CLCN7 | H(+)/Cl(-) exchange transporter 7 | Homo sapiens (Human) | PR |
| O35454 | Clcn6 | H(+)/Cl(-) exchange transporter 6 | Mus musculus (Mouse) | PR |
| O70496 | Clcn7 | H(+)/Cl(-) exchange transporter 7 | Mus musculus (Mouse) | PR |
| Q61418 | Clcn4 | H(+)/Cl(-) exchange transporter 4 | Mus musculus (Mouse) | PR |
| P60300 | CLC-G | Putative chloride channel-like protein CLC-g | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MANVSKKVSW | SGRDRDDEEG | APLLRRTGQP | DEETPLLNGA | GPGARQSHSA | LFRIGQMNNV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ELDDELLDPE | VDPPHTFPKE | IPHNEKLLSL | KYESLDYDNS | ENQLFLEEER | RINHTAFRTV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EIKRWVICAL | IGILTGLVAC | FIDIVVENLA | GLKYRVIKDN | IDKFTEKGGL | SFSLLLWATL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NSAFVLVGSV | IVAFIEPVAA | GSGIPQIKCF | LNGVKIPHVV | RLKTLVIKVS | GVILSVVGGL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AVGKEGPMIH | SGSVIAAGIS | QGRSTSLKRD | FKIFEYFRRD | TEKRDFVSAG | AAAGVSAAFG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| APVGGVLFSL | EEGASFWNQF | LTWRIFFASM | ISTFTLNFVL | SIYHGNMWDL | SSPGLINFGR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FDSEKMAYTI | HEIPVFIAMG | VVGGILGAVF | NALNYWLTMF | RIRYIHRPCL | QVIEAMLVAA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VTATVAFVLI | YSSRDCQPLQ | GSSMSYPLQL | FCADGEYNSM | AAAFFNTPEK | SVVSLFHDPP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GSYNPMTLGL | FTLVYFFLAC | WTYGLTVSAG | VFIPSLLIGA | AWGRLFGISM | SYLTGAAIWA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DPGKYALMGA | AAQLGGIVRM | TLSLTVIMME | ATSNVTYGFP | IMLVLMTAKI | VGDVFIEGLY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DMHIQLQSVP | FLHWEAPVTS | HSLTAREVMS | TPVTCLRRRE | KVGIIVDVLS | DTASNHNGFP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VVEDVGDTQP | ARLQGLILRS | QLIVLLKHKV | FVERSNMGLV | QRRLRLKDFR | DAYPRFPPIQ |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SIHVSQDERE | CTMDLSEFMN | PSPYTVPQEA | SLPRVFKLFR | ALGLRHLVVV | DNHNQVVGLV |
| 790 | 800 | ||||
| TRKDLARYRL | GKGGLEELSL | AQT |