P37020
PR
Gene name |
GEF1 (CLCY1, YJR040W, J1616) |
Protein name |
Anion/proton exchange transporter GEF1 |
Names |
CLC protein GEF1, ClC-A, ClC-Y1, Voltage-gated chloride channel |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YJR040W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P37020
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P37020-F1 | Predicted | AlphaFoldDB |
11 variants for P37020
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s10-507775 | 13 | G>R | No | SGRP | |
| s10-508230 | 164 | L>F | No | SGRP | |
| s10-508320 | 194 | W>C | No | SGRP | |
| s10-508359 | 207 | F>L | No | SGRP | |
| s10-508507 | 257 | S>T | No | SGRP | |
| s10-508522 | 262 | I>L | No | SGRP | |
| s10-509063 | 442 | T>I | No | SGRP | |
| s10-509228 | 497 | T>I | No | SGRP | |
| s10-509818 | 694 | S>T | No | SGRP | |
| s10-510037 | 767 | I>V | No | SGRP | |
| s10-510041 | 768 | K>R | No | SGRP |
No associated diseases with P37020
2 regional properties for P37020
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | CBS domain | 588 - 659 | IPR000644-1 |
| domain | CBS domain | 685 - 738 | IPR000644-2 |
Functions
11 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloride channel complex | An ion channel complex through which chloride ions pass. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| fungal-type vacuole | A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi medial cisterna | The middle Golgi cisterna (or cisternae). |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| solute:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). |
| voltage-gated chloride channel activity | Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular copper ion homeostasis | Any process involved in the maintenance of an internal steady state of copper ions at the level of a cell. |
| cellular iron ion homeostasis | Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell. |
| regulation of iron ion transport | Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P51790 | CLCN3 | H(+)/Cl(-) exchange transporter 3 | Homo sapiens (Human) | PR |
| Q61418 | Clcn4 | H(+)/Cl(-) exchange transporter 4 | Mus musculus (Mouse) | PR |
| P51791 | Clcn3 | H(+)/Cl(-) exchange transporter 3 | Mus musculus (Mouse) | PR |
| P51792 | Clcn3 | H(+)/Cl(-) exchange transporter 3 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPTTYVPINQ | PIGDGEDVID | TNRFTNIPET | QNFDQFVTID | KIAEENRPLS | VDSDREFLNS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KYRHYREVIW | DRAKTFITLS | STAIVIGCIA | GFLQVFTETL | VNWKTGHCQR | NWLLNKSFCC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NGVVNEVTST | SNLLLKRQEF | ECEAQGLWIA | WKGHVSPFII | FMLLSVLFAL | ISTLLVKYVA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PMATGSGISE | IKVWVSGFEY | NKEFLGFLTL | VIKSVALPLA | ISSGLSVGKE | GPSVHYATCC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GYLLTKWLLR | DTLTYSSQYE | YITAASGAGV | AVAFGAPIGG | VLFGLEEIAS | ANRFNSSTLW |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KSYYVALVAI | TTLKYIDPFR | NGRVILFNVT | YDRDWKVQEI | PIFIALGIFG | GLYGKYISKW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NINFIHFRKM | YLSSWPVQEV | LFLATLTALI | SYFNEFLKLD | MTESMGILFH | ECVKNDNTST |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FSHRLCQLDE | NTHAFEFLKI | FTSLCFATVI | RALLVVVSYG | ARVPAGIFVP | SMAVGATFGR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AVSLLVERFI | SGPSVITPGA | YAFLGAAATL | SGITNLTLTV | VVIMFELTGA | FMYIIPLMIV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VAITRIILST | SGISGGIADQ | MIMVNGFPYL | EDEQDEEEEE | TLEKYTAEQL | MSSKLITINE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TIYLSELESL | LYDSASEYSV | HGFPITKDED | KFEKEKRCIG | YVLKRHLASK | IMMQSVNSTK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AQTTLVYFNK | SNEELGHREN | CIGFKDIMNE | SPISVKKAVP | VTLLFRMFKE | LGCKTIIVEE |
| 730 | 740 | 750 | 760 | 770 | |
| SGILKGLVTA | KDILRFKRIK | YREVHGAKFT | YNEALDRRCW | SVIHFIIKRF | TTNRNGNVI |