P35030

PR
Gene name
PRSS3 (PRSS4, TRY3, TRY4)
Protein name
Trypsin-3
Names
Brain trypsinogen, Mesotrypsin, Mesotrypsinogen, Serine protease 3, Serine protease 4, Trypsin III, Trypsin IV
Species
Homo sapiens (Human)
KEGG Pathway
hsa:5646
EC number
3.4.21.4: Serine endopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-71 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

15 structures for P35030

Entry ID Method Resolution Chain Position Source
1H4W X-ray 170 A A 81-304 PDB
2R9P X-ray 140 A A/B/C/D 81-304 PDB
3L33 X-ray 248 A A/B/C/D 81-304 PDB
3L3T X-ray 238 A A/B/C/D 81-304 PDB
3P92 X-ray 160 A A 81-304 PDB
3P95 X-ray 130 A A 81-304 PDB
4DG4 X-ray 140 A A/B/D/G 81-304 PDB
4U30 X-ray 250 A A/B/C/D 81-304 PDB
4U32 X-ray 165 A A 81-304 PDB
5C67 X-ray 183 A A/B 81-304 PDB
5JBT X-ray 140 A A 81-304 PDB
5TP0 X-ray 125 A A 81-304 PDB
6BX8 X-ray 198 A A/C/E/G 81-304 PDB
6GFI X-ray 230 A A/B 81-304 PDB
AF-P35030-F1 Predicted AlphaFoldDB

4 variants for P35030

Variant ID(s) Position Change Description Diseaes Association Provenance
rs11547028
VAR_067459
 174 A>V No UniProt
dbSNP
VAR_046794
rs855581
 188 T>A No UniProt
dbSNP
VAR_059788
rs1063273
 224 T>S No UniProt
dbSNP
rs1048379
VAR_046795
 232 Y>C No UniProt
dbSNP

No associated diseases with P35030

2 regional properties for P35030

Type Name Position InterPro Accession
domain Serine proteases, trypsin domain 80 - 301 IPR001254
active_site Serine proteases, trypsin family, histidine active site 116 - 121 IPR018114

Functions

Description
EC Number 3.4.21.4 Serine endopeptidases
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
tertiary granule lumen Any membrane-enclosed lumen that is part of a tertiary granule.

3 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
serine-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

5 GO annotations of biological process

Name Definition
antimicrobial humoral response An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.
digestion The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
endothelial cell migration The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
zymogen activation The proteolytic processing of an inactive enzyme to an active form.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P05049 snk Serine protease snake Drosophila melanogaster (Fruit fly) PR
Q6UWB4 PRSS55 Serine protease 55 Homo sapiens (Human) PR
Q9UI38 PRSS50 Probable threonine protease PRSS50 Homo sapiens (Human) PR
E5RG02 PRSS46P Putative serine protease 46 Homo sapiens (Human) PR
P0CW18 PRSS56 Serine protease 56 Homo sapiens (Human) PR
P15119 Mcpt2 Mast cell protease 2 Mus musculus (Mouse) PR
Q9DBI0 Tmprss6 Transmembrane protease serine 6 Mus musculus (Mouse) PR
P98064 Masp1 Mannan-binding lectin serine protease 1 Mus musculus (Mouse) PR
Q402U7 Prss44 Serine protease 44 Mus musculus (Mouse) PR
Q8CHN8 Masp1 Mannan-binding lectin serine protease 1 Rattus norvegicus (Rat) PR
Q6IE63 Prss46 Serine protease 46 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MCGPDDRCPA RWPGPGRAVK CGKGLAAARP GRVERGGAQR GGAGLELHPL LGGRTWRAAR
70 80 90 100 110 120
DADGCEALGT VAVPFDDDDK IVGGYTCEEN SLPYQVSLNS GSHFCGGSLI SEQWVVSAAH
130 140 150 160 170 180
CYKTRIQVRL GEHNIKVLEG NEQFINAAKI IRHPKYNRDT LDNDIMLIKL SSPAVINARV
190 200 210 220 230 240
STISLPTTPP AAGTECLISG WGNTLSFGAD YPDELKCLDA PVLTQAECKA SYPGKITNSM
250 260 270 280 290 300
FCVGFLEGGK DSCQRDSGGP VVCNGQLQGV VSWGHGCAWK NRPGVYTKVY NYVDWIKDTI
AANS