P05049
Gene name |
snk (CG7996) |
Protein name |
Serine protease snake |
Names |
|
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG7996 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P05049
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P05049-F1 | Predicted | AlphaFoldDB |
No variants for P05049
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P05049 | |||||
No associated diseases with P05049
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| serine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| dorsal/ventral axis specification | The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. |
| positive regulation of Toll signaling pathway | Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
| zymogen activation | The proteolytic processing of an inactive enzyme to an active form. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6UWB4 | PRSS55 | Serine protease 55 | Homo sapiens (Human) | PR |
| P35030 | PRSS3 | Trypsin-3 | Homo sapiens (Human) | PR |
| Q9UI38 | PRSS50 | Probable threonine protease PRSS50 | Homo sapiens (Human) | PR |
| E5RG02 | PRSS46P | Putative serine protease 46 | Homo sapiens (Human) | PR |
| P0CW18 | PRSS56 | Serine protease 56 | Homo sapiens (Human) | PR |
| P15119 | Mcpt2 | Mast cell protease 2 | Mus musculus (Mouse) | PR |
| Q9DBI0 | Tmprss6 | Transmembrane protease serine 6 | Mus musculus (Mouse) | PR |
| P98064 | Masp1 | Mannan-binding lectin serine protease 1 | Mus musculus (Mouse) | PR |
| Q402U7 | Prss44 | Serine protease 44 | Mus musculus (Mouse) | PR |
| Q8CHN8 | Masp1 | Mannan-binding lectin serine protease 1 | Rattus norvegicus (Rat) | PR |
| Q6IE63 | Prss46 | Serine protease 46 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIILWSLIVH | LQLTCLHLIL | QTPNLEALDA | LEIINYQTTK | YTIPEVWKEQ | PVATIGEDVD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DQDTEDEESY | LKFGDDAEVR | TSVSEGLHEG | AFCRRSFDGR | SGYCILAYQC | LHVIREYRVH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GTRIDICTHR | NNVPVICCPL | ADKHVLAQRI | SATKCQEYNA | AARRLHLTDT | GRTFSGKQCV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PSVPLIVGGT | PTRHGLFPHM | AALGWTQGSG | SKDQDIKWGC | GGALVSELYV | LTAAHCATSG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SKPPDMVRLG | ARQLNETSAT | QQDIKILIIV | LHPKYRSSAY | YHDIALLKLT | RRVKFSEQVR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PACLWQLPEL | QIPTVVAAGW | GRTEFLGAKS | NALRQVDLDV | VPQMTCKQIY | RKERRLPRGI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IEGQFCAGYL | PGGRDTCQGD | SGGPIHALLP | EYNCVAFVVG | ITSFGKFCAA | PNAPGVYTRL |
| 430 | |||||
| YSYLDWIEKI | AFKQH |