E5RG02

PR
Gene name
PRSS46P
Protein name
Putative serine protease 46
Names
Serine protease 46 pseudogene
Species
Homo sapiens (Human)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for E5RG02

Entry ID Method Resolution Chain Position Source
AF-E5RG02-F1 Predicted AlphaFoldDB

No variants for E5RG02

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for E5RG02

No associated diseases with E5RG02

2 regional properties for E5RG02

Type Name Position InterPro Accession
domain Serine proteases, trypsin domain 42 - 174 IPR001254
active_site Serine proteases, trypsin family, histidine active site 79 - 84 IPR018114

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

1 GO annotations of biological process

Name Definition
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P05049 snk Serine protease snake Drosophila melanogaster (Fruit fly) PR
Q6UWB4 PRSS55 Serine protease 55 Homo sapiens (Human) PR
P35030 PRSS3 Trypsin-3 Homo sapiens (Human) PR
Q9UI38 PRSS50 Probable threonine protease PRSS50 Homo sapiens (Human) PR
P0CW18 PRSS56 Serine protease 56 Homo sapiens (Human) PR
P15119 Mcpt2 Mast cell protease 2 Mus musculus (Mouse) PR
Q9DBI0 Tmprss6 Transmembrane protease serine 6 Mus musculus (Mouse) PR
P98064 Masp1 Mannan-binding lectin serine protease 1 Mus musculus (Mouse) PR
Q402U7 Prss44 Serine protease 44 Mus musculus (Mouse) PR
Q8CHN8 Masp1 Mannan-binding lectin serine protease 1 Rattus norvegicus (Rat) PR
Q6IE63 Prss46 Serine protease 46 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MACGPGDLQS LTSPLSSARL DYQPSIEGPW LRACGQTNVS CRVVKGKLVE VGKWPWQVSI
70 80 90 100 110 120
LFLGTYICSG SLIHHQWVLT AAHCLQRFKD LSLYSVMVGV HQRPENSTQL PLTRMVIHKD
130 140 150 160 170
FSNLMSQDIA LLKLRDSISW SPFVQPVCLP NIKFKPSIGS MCWVIGWGTT GKKG