AiPD: Autoinhibited Protein Database

Gene name	Prss44
Protein name	Serine protease 44
Names	Testis serine protease 4, TESSP-4, Testis-specific serine protease 4
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:73336
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-132 (Predicted disordered autoinhibitory region) PR

1-132 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q402U7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs219140463	5	G>D	No	EVA
rs239168845	9	F>L	No	EVA
rs33300200	14	W>C	No	EVA
rs224686979	21	R>Q	No	EVA
rs246829550	28	V>I	No	EVA
rs3389076372	49	N>I	No	EVA
rs3389077435	56	T>S	No	EVA
rs33300202	65	R>G	No	EVA
rs254768378	74	L>P	No	EVA
rs213421935	180	Q>R	No	EVA
rs3389076436	204	A>V	No	EVA
rs236740530	211	V>I	No	EVA
rs33300788	229	T>M	No	EVA
rs3389073154	236	W>*	No	EVA
rs3389078731	249	L>M	No	EVA
rs3389057199	275	T>I	No	EVA
rs3413000887	281	G>E	No	EVA
rs3389077464	305	F>Y	No	EVA
rs3389082946	324	I>V	No	EVA
rs3389023849	328	G>V	No	EVA
rs3389057082	341	I>T	No	EVA
rs237055309	351	K>N	No	EVA
rs263012465	357	V>I	No	EVA

Type	Name	Position	InterPro Accession
domain	Serine proteases, trypsin domain	111 - 345	IPR001254
active_site	Serine proteases, trypsin family, histidine active site	148 - 153	IPR018114
active_site	Serine proteases, trypsin family, serine active site	291 - 302	IPR033116

		Description
EC Number
Subcellular Localization	Membrane ; Single-pass membrane protein Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
serine-type endopeptidase activity	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

Name	Definition
germ cell development	The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
proteolysis	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P05049	snk	Serine protease snake	Drosophila melanogaster (Fruit fly)	PR
Q6UWB4	PRSS55	Serine protease 55	Homo sapiens (Human)	PR
P35030	PRSS3	Trypsin-3	Homo sapiens (Human)	PR
Q9UI38	PRSS50	Probable threonine protease PRSS50	Homo sapiens (Human)	PR
E5RG02	PRSS46P	Putative serine protease 46	Homo sapiens (Human)	PR
P0CW18	PRSS56	Serine protease 56	Homo sapiens (Human)	PR
Q6IE63	Prss46	Serine protease 46	Rattus norvegicus (Rat)	PR