AiPD: Autoinhibited Protein Database

Gene name	Masp1 (Crarf, Masp3)
Protein name	Mannan-binding lectin serine protease 1
Names	Complement factor MASP-3, Complement-activating component of Ra-reactive factor, Mannose-binding lectin-associated serine protease 1, MASP-1, Mannose-binding protein-associated serine protease, Ra-reactive factor serine protease p100, RaRF, Serine protease 5
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:17174
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

600-672 (Predicted disordered autoinhibitory region) PR

600-672 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P98064-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs16785980	8	R>Q	No	EVA
rs3406680728	25	H>Q	No	EVA
rs3406590275	26	T>G	No	EVA
rs3389400701	28	E>D	No	EVA
rs3389426732	47	S>R	No	EVA
rs224852198	51	V>M	No	EVA
rs3389368921	83	V>A	No	EVA
rs3389416266	103	T>I	No	EVA
rs3389402518	135	G>D	No	EVA
rs3389416247	154	E>D	No	EVA
rs3389378050	172	S>F	No	EVA
rs3389419323	179	L>V	No	EVA
rs3389406631	186	C>Y	No	EVA
rs3389419302	199	T>S	No	EVA
rs3389416241	202	I>V	No	EVA
rs3389413669	251	Y>D	No	EVA
rs3389389464	295	W>R	No	EVA
rs3389406664	331	L>I	No	EVA
rs3389419325	336	T>A	No	EVA
rs16784735	366	T>I	No	EVA
rs3389378015	370	V>A	No	EVA
rs216430032	370	V>I	No	EVA
rs3389377996	371	D>E	No	EVA
rs3389389521	389	N>Y	No	EVA
rs3389410058	468	I>F	No	EVA
rs6219495	499	Q>H	No	EVA
rs3389426684	499	Q>K	No	EVA
rs3389419270	529	R>L	No	EVA
rs16784107	550	N>D	No	EVA
rs3389325341	581	Q>*	No	EVA
rs16784086	584	T>A	No	EVA
rs3389419324	624	T>I	No	EVA
rs3389368926	635	I>F	No	EVA
rs3389416216	656	V>M	No	EVA
rs3412696403	659	D>V	No	EVA
rs16784129	698	R>T	No	EVA
rs16784130	705	N>R	No	EVA

Type	Name	Position	InterPro Accession
domain	Sushi/SCR/CCP domain	304 - 369	IPR000436-1
domain	Sushi/SCR/CCP domain	370 - 439	IPR000436-2
domain	EGF-like domain	171 - 186	IPR000742
domain	CUB domain	16 - 143	IPR000859-1
domain	CUB domain	190 - 302	IPR000859-2
domain	Serine proteases, trypsin domain	453 - 701	IPR001254
domain	EGF-like calcium-binding domain	144 - 187	IPR001881
conserved_site	EGF-like calcium-binding, conserved site	144 - 171	IPR018097
active_site	Serine proteases, trypsin family, histidine active site	491 - 496	IPR018114
active_site	Serine proteases, trypsin family, serine active site	645 - 656	IPR033116

		Description
EC Number
Subcellular Localization	Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
serine-type endopeptidase complex	A protein complex which is capable of serine-type endopeptidase activity.

Name	Definition
calcium ion binding	Binding to a calcium ion (Ca2+).
calcium-dependent protein binding	Binding to a protein or protein complex in the presence of calcium.
identical protein binding	Binding to an identical protein or proteins.
peptidase activity	Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
serine-type endopeptidase activity	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

Name	Definition
cell surface pattern recognition receptor signaling pathway	The series of molecular signals initiated by a ligand binding to a cell surface pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.
complement activation, lectin pathway	Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
negative regulation of complement activation	Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.
positive regulation of opsonization	Any process that activates or increases the frequency, rate or extent of opsonization.
proteolysis	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P05049	snk	Serine protease snake	Drosophila melanogaster (Fruit fly)	PR
Q6UWB4	PRSS55	Serine protease 55	Homo sapiens (Human)	PR
P35030	PRSS3	Trypsin-3	Homo sapiens (Human)	PR
Q9UI38	PRSS50	Probable threonine protease PRSS50	Homo sapiens (Human)	PR
E5RG02	PRSS46P	Putative serine protease 46	Homo sapiens (Human)	PR
P0CW18	PRSS56	Serine protease 56	Homo sapiens (Human)	PR
P15119	Mcpt2	Mast cell protease 2	Mus musculus (Mouse)	PR
Q9DBI0	Tmprss6	Transmembrane protease serine 6	Mus musculus (Mouse)	PR
Q6IE63	Prss46	Serine protease 46	Rattus norvegicus (Rat)	PR
Q8CHN8	Masp1	Mannan-binding lectin serine protease 1	Rattus norvegicus (Rat)	PR