P15119

PR
Gene name
Mcpt2
Protein name
Mast cell protease 2
Names
Neural cadherin, N-cadherin, mMCP-2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:17225
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P15119

Entry ID Method Resolution Chain Position Source
AF-P15119-F1 Predicted AlphaFoldDB

34 variants for P15119

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389329290 18 A>V No EVA
rs3389349700 25 V>L No EVA
rs50009190 28 K>R No EVA
rs3389287354 40 F>S No EVA
rs3389331658 47 K>E No EVA
rs8244237 67 N>K No EVA
rs8244238 67 N>S No EVA
rs1132378009 78 H>N No EVA
rs3389314521 89 I>K No EVA
rs585379384 90 I>T No EVA
rs8244245 107 F>C No EVA
rs8244245 107 F>Y No EVA
rs6262654 108 Y>N No EVA
rs3389329217 118 K>T No EVA
rs8244242 124 D>A No EVA
rs1132394696 126 D>A No EVA
rs583971110 126 D>N No EVA
rs3389328948 135 D>V No EVA
rs3389304756 142 M>I No EVA
rs3389338719 150 K>E No EVA
rs8244240 153 K>N No EVA
rs30607436 178 S>N No EVA
rs30495805 194 S>L No EVA
rs3389287346 200 G>* No EVA
rs3389314593 201 D>Y No EVA
rs8240089 210 S>G No EVA
rs3389349717 210 S>N No EVA
rs585755659 219 Y>* No EVA
rs582090080 219 Y>S No EVA
rs580109282 223 A>P No EVA
rs587533488 232 Y>* No EVA
rs584150947 232 Y>S No EVA
rs3389328998 239 K>I No EVA
rs579693515 243 S>G No EVA

No associated diseases with P15119

3 regional properties for P15119

Type Name Position InterPro Accession
domain Serine proteases, trypsin domain 20 - 242 IPR001254
active_site Serine proteases, trypsin family, histidine active site 61 - 66 IPR018114
active_site Serine proteases, trypsin family, serine active site 196 - 207 IPR033116

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

1 GO annotations of biological process

Name Definition
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P05049 snk Serine protease snake Drosophila melanogaster (Fruit fly) PR
Q6UWB4 PRSS55 Serine protease 55 Homo sapiens (Human) PR
P35030 PRSS3 Trypsin-3 Homo sapiens (Human) PR
Q9UI38 PRSS50 Probable threonine protease PRSS50 Homo sapiens (Human) PR
E5RG02 PRSS46P Putative serine protease 46 Homo sapiens (Human) PR
P0CW18 PRSS56 Serine protease 56 Homo sapiens (Human) PR
Q9DBI0 Tmprss6 Transmembrane protease serine 6 Mus musculus (Mouse) PR
P98064 Masp1 Mannan-binding lectin serine protease 1 Mus musculus (Mouse) PR
Q6IE63 Prss46 Serine protease 46 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MQALLFLMAL LLPSGAGAEE IIGGVEAKPH SRPYMAYLKF TTKNGSKERC GGFLIAPQFV
70 80 90 100 110 120
MTAAHCNGSE ISVILGAHNI NKNEPTQQII KTEKTFVHPK FQYLSGFYDI MLLKLQKKAE
130 140 150 160 170 180
LNSDVDVISL PSSSDFIKPG KMCWTAGWGK TGKNNPLSVT LREVELRIMD QEACKDHSDY
190 200 210 220 230 240
DYQLQVCAGS PTTSKSIGQG DSGGPLVCDS VAHGIASSYE AKAPAVFTRI SYYLPWIYKV
LKSK