Q9DBI0
PR
Gene name |
Tmprss6 |
Protein name |
Transmembrane protease serine 6 |
Names |
Matriptase-2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:71753 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9DBI0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9DBI0-F1 | Predicted | AlphaFoldDB |
42 variants for Q9DBI0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs233548002 | 16 | T>A | No | EVA | |
| rs3389374527 | 29 | G>V | No | EVA | |
| rs241229450 | 43 | P>T | No | EVA | |
| rs220968295 | 44 | P>L | No | EVA | |
| rs3389366763 | 55 | V>I | No | EVA | |
| rs235209322 | 99 | R>H | No | EVA | |
| rs3389377889 | 106 | G>V | No | EVA | |
| rs3389341767 | 116 | E>K | No | EVA | |
| rs3389388607 | 149 | P>H | No | EVA | |
| rs3389374450 | 164 | Q>E | No | EVA | |
| rs259630132 | 175 | E>K | No | EVA | |
| rs240562904 | 179 | D>G | No | EVA | |
| rs31537716 | 185 | S>G | No | EVA | |
| rs3406279675 | 189 | A>D | No | EVA | |
| rs3406014256 | 190 | S>A | No | EVA | |
| rs3389369648 | 212 | I>M | No | EVA | |
| rs3389388608 | 213 | V>I | No | EVA | |
| rs1132865143 | 229 | P>L | No | EVA | |
| rs3404744567 | 331 | A>P | No | EVA | |
| rs3389374445 | 362 | P>S | No | EVA | |
| rs3406013403 | 430 | V>D | No | EVA | |
| rs3389369652 | 456 | D>N | No | EVA | |
| rs3389341765 | 465 | S>F | No | EVA | |
| rs3389323285 | 499 | E>D | No | EVA | |
| rs3389323239 | 500 | D>A | No | EVA | |
| rs31534017 | 515 | D>N | No | EVA | |
| rs3389369643 | 524 | Q>E | No | EVA | |
| rs3389370762 | 546 | K>N | No | EVA | |
| rs3406483296 | 564 | Q>H | No | EVA | |
| rs3389369633 | 600 | H>Y | No | EVA | |
| rs3389351809 | 628 | K>* | No | EVA | |
| rs3389341806 | 636 | K>* | No | EVA | |
| rs3389374296 | 641 | S>* | No | EVA | |
| rs3389351825 | 658 | P>L | No | EVA | |
| rs3389366825 | 660 | H>L | No | EVA | |
| rs13463055 | 691 | A>T | No | EVA | |
| rs3389388590 | 716 | V>M | No | EVA | |
| rs3389377882 | 744 | R>H | No | EVA | |
| rs3389334848 | 787 | C>Y | No | EVA | |
| rs3412733130 | 799 | V>A | No | EVA | |
| rs3389370807 | 800 | T>R | No | EVA | |
| rs31539694 | 808 | Q>R | No | EVA |
No associated diseases with Q9DBI0
8 regional properties for Q9DBI0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SEA domain | 86 - 209 | IPR000082 |
| domain | CUB domain | 335 - 452 | IPR000859 |
| domain | Serine proteases, trypsin domain | 576 - 811 | IPR001254 |
| repeat | Low-density lipoprotein (LDL) receptor class A repeat | 457 - 490 | IPR002172-1 |
| repeat | Low-density lipoprotein (LDL) receptor class A repeat | 490 - 527 | IPR002172-2 |
| repeat | Low-density lipoprotein (LDL) receptor class A repeat | 530 - 568 | IPR002172-3 |
| active_site | Serine proteases, trypsin family, histidine active site | 613 - 618 | IPR018114 |
| active_site | Serine proteases, trypsin family, serine active site | 756 - 767 | IPR033116 |
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| serine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| BMP signaling pathway | The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| cellular iron ion homeostasis | Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell. |
| fibrinolysis | A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin. |
| iron ion homeostasis | Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell. |
| membrane protein proteolysis | The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains. |
| negative regulation of BMP signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
| self proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P05049 | snk | Serine protease snake | Drosophila melanogaster (Fruit fly) | PR |
| Q6UWB4 | PRSS55 | Serine protease 55 | Homo sapiens (Human) | PR |
| P35030 | PRSS3 | Trypsin-3 | Homo sapiens (Human) | PR |
| Q9UI38 | PRSS50 | Probable threonine protease PRSS50 | Homo sapiens (Human) | PR |
| E5RG02 | PRSS46P | Putative serine protease 46 | Homo sapiens (Human) | PR |
| P0CW18 | PRSS56 | Serine protease 56 | Homo sapiens (Human) | PR |
| P15119 | Mcpt2 | Mast cell protease 2 | Mus musculus (Mouse) | PR |
| P98064 | Masp1 | Mannan-binding lectin serine protease 1 | Mus musculus (Mouse) | PR |
| Q6IE63 | Prss46 | Serine protease 46 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPRCFQLPCS | TRMPTTEVPQ | AADGQGDAGD | GEEAAEPEGK | FKPPKNTKRK | NRDYVRFTPL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLVLAALVSA | GVMLWYFLGY | KAEVTVSQVY | SGSLRVLNRH | FSQDLGRRES | IAFRSESAKA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QKMLQELVAS | TRLGTYYNSS | SVYSFGEGPL | TCFFWFILDI | PEYQRLTLSP | EVVRELLVDE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LLSNSSTLAS | YKTEYEVDPE | GLVILEASVN | DIVVLNSTLG | CYRYSYVNPG | QVLPLKGPDQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QTTSCLWHLQ | GPEDLMIKVR | LEWTRVDCRD | RVAMYDAAGP | LEKRLITSVY | GCSRQEPVME |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VLASGSVMAV | VWKKGMHSYY | DPFLLSVKSV | AFQDCQVNLT | LEGRLDTQGF | LRTPYYPSYY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SPSTHCSWHL | TVPSLDYGLA | LWFDAYALRR | QKYNRLCTQG | QWMIQNRRLC | GFRTLQPYAE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RIPMVASDGV | TINFTSQISL | TGPGVQVYYS | LYNQSDPCPG | EFLCSVNGLC | VPACDGIKDC |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PNGLDERNCV | CRAMFQCQED | STCISLPRVC | DRQPDCLNGS | DEEQCQEGVP | CGTFTFQCED |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RSCVKKPNPE | CDGQSDCRDG | SDEQHCDCGL | QGLSSRIVGG | TVSSEGEWPW | QASLQIRGRH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ICGGALIADR | WVITAAHCFQ | EDSMASPKLW | TVFLGKMRQN | SRWPGEVSFK | VSRLFLHPYH |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EEDSHDYDVA | LLQLDHPVVY | SATVRPVCLP | ARSHFFEPGQ | HCWITGWGAQ | REGGPVSNTL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QKVDVQLVPQ | DLCSEAYRYQ | VSPRMLCAGY | RKGKKDACQG | DSGGPLVCRE | PSGRWFLAGL |
| 790 | 800 | 810 | |||
| VSWGLGCGRP | NFFGVYTRVT | RVINWIQQVL | T |