P28470
Gene name |
Ppp3r2 (Cblp) |
Protein name |
Calcineurin subunit B type 2 |
Names |
Calcineurin B-like protein, CBLP, Protein phosphatase 2B regulatory subunit 2, Protein phosphatase 3 regulatory subunit B beta isoform |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:29749 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P28470
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P28470-F1 | Predicted | AlphaFoldDB |
No variants for P28470
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P28470 | |||||
No associated diseases with P28470
7 regional properties for P28470
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EF-hand domain | 18 - 53 | IPR002048-1 |
| domain | EF-hand domain | 54 - 85 | IPR002048-2 |
| domain | EF-hand domain | 87 - 163 | IPR002048-3 |
| binding_site | EF-Hand 1, calcium-binding site | 31 - 43 | IPR018247-1 |
| binding_site | EF-Hand 1, calcium-binding site | 63 - 75 | IPR018247-2 |
| binding_site | EF-Hand 1, calcium-binding site | 100 - 112 | IPR018247-3 |
| binding_site | EF-Hand 1, calcium-binding site | 141 - 153 | IPR018247-4 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| calcineurin complex | A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| sperm flagellum | A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid. |
| sperm midpiece | The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece. |
| sperm mitochondrial sheath | The tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| calcium-dependent protein serine/threonine phosphatase regulator activity | Binds to and modulates of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase. |
| phosphatase binding | Binding to a phosphatase. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| calcineurin-mediated signaling | Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression. |
| penetration of zona pellucida | The infiltration by sperm of the zona pellucida to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm. |
| protein dephosphorylation | The process of removing one or more phosphoric residues from a protein. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P63099 | PPP3R1 | Calcineurin subunit B type 1 | Bos taurus (Bovine) | PR |
| Q2TBI5 | PPP3R2 | Calcineurin subunit B type 2 | Bos taurus (Bovine) | PR |
| A0AVX7 | TESC | Calcineurin B homologous protein 3 | Gallus gallus (Chicken) | PR |
| Q96BS2 | TESC | Calcineurin B homologous protein 3 | Homo sapiens (Human) | PR |
| P63098 | PPP3R1 | Calcineurin subunit B type 1 | Homo sapiens (Human) | PR |
| Q96LZ3 | PPP3R2 | Calcineurin subunit B type 2 | Homo sapiens (Human) | PR |
| Q9JKL5 | Tesc | Calcineurin B homologous protein 3 | Mus musculus (Mouse) | PR |
| Q63810 | Ppp3r1 | Calcineurin subunit B type 1 | Mus musculus (Mouse) | PR |
| P63100 | Ppp3r1 | Calcineurin subunit B type 1 | Rattus norvegicus (Rat) | PR |
| Q75KU4 | CBL4 | Calcineurin B-like protein 4 | Oryza sativa subsp japonica (Rice) | PR |
| Q7XC27 | CBL1 | Calcineurin B-like protein 1 | Oryza sativa subsp japonica (Rice) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGNEASYHSE | MGTHFDHDEI | KRLGRSFKKM | DLDKSGSLSV | DEFMSLPELQ | QNPLVGRVID |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IFDTDGNGEV | DFREFIVGTS | QFSVKGDEEQ | KLRFAFRIYD | MDNDGFISNG | ELFQVLKMMV |
| 130 | 140 | 150 | 160 | 170 | |
| GNNLKDWQLQ | QLVDKSILVL | DKDGDGRISF | EEFRDVVRTM | EIHKKLVVFV | DHGQED |