P63098
PR
Gene name |
PPP3R1 (CNA2, CNB) |
Protein name |
Calcineurin subunit B type 1 |
Names |
Protein phosphatase 2B regulatory subunit 1, Protein phosphatase 3 regulatory subunit B alpha isoform 1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:5534 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
15 structures for P63098
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1AUI | X-ray | 210 A | B | 2-170 | PDB |
| 1M63 | X-ray | 280 A | B/F | 2-170 | PDB |
| 1MF8 | X-ray | 310 A | B | 1-170 | PDB |
| 2P6B | X-ray | 230 A | B/D | 16-170 | PDB |
| 3LL8 | X-ray | 200 A | B/D | 16-170 | PDB |
| 4F0Z | X-ray | 170 A | B | 1-170 | PDB |
| 4OR9 | X-ray | 223 A | B | 1-170 | PDB |
| 4ORA | X-ray | 275 A | B | 1-170 | PDB |
| 4ORC | X-ray | 270 A | B | 1-170 | PDB |
| 5SVE | X-ray | 260 A | B | 1-170 | PDB |
| 6NUC | X-ray | 190 A | B | 16-170 | PDB |
| 6NUF | X-ray | 190 A | B | 16-170 | PDB |
| 6NUU | X-ray | 230 A | B | 16-170 | PDB |
| 7U0T | X-ray | 245 A | A | 3-170 | PDB |
| AF-P63098-F1 | Predicted | AlphaFoldDB |
43 variants for P63098
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs61757747 CA49414831 |
2 | G>E | No |
ClinGen Ensembl |
|
| TCGA novel | 5 | A>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA347085551 rs1224065747 |
6 | S>I | No |
ClinGen gnomAD |
|
|
rs1343460209 CA347106239 |
16 | D>G | No |
ClinGen gnomAD |
|
|
CA49415495 rs200459875 |
17 | A>E | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA1689908 rs200459875 |
17 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA gnomAD |
|
rs866820627 CA49415481 |
37 | S>T | No |
ClinGen Ensembl |
|
| TCGA novel | 45 | S>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA347106028 rs1484879018 |
46 | L>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA49415477 rs4482466 |
49 | L>S | No |
ClinGen Ensembl |
|
|
CA347106004 rs1238666263 |
50 | Q>* | No |
ClinGen gnomAD |
|
|
rs1326798628 CA347105955 |
56 | Q>H | No |
ClinGen TOPMed |
|
|
rs1322381430 CA347105957 |
56 | Q>R | No |
ClinGen gnomAD |
|
|
rs951794466 CA49415463 |
57 | R>* | No |
ClinGen Ensembl |
|
|
rs751778712 CA1689904 |
61 | I>T | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 75 | F>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA347104822 rs1460224986 |
79 | V>I | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 88 | K>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA1689877 rs754390079 |
89 | E>K | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 90 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1351441285 CA347104392 |
95 | A>S | No |
ClinGen gnomAD |
|
|
rs1260240599 CA347104383 |
95 | A>V | No |
ClinGen gnomAD |
|
|
rs1314205246 CA347104357 |
97 | R>C | No |
ClinGen gnomAD |
|
|
CA1689858 rs766588543 |
97 | R>L | No |
ClinGen ExAC gnomAD |
|
|
rs369235532 COSM1142702 CA1689857 |
98 | I>V | lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA |
| TCGA novel | 105 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA347104194 rs1343428189 |
106 | Y>H | No |
ClinGen gnomAD |
|
| TCGA novel | 107 | I>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA1689856 rs750942939 |
111 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA49414762 rs866497953 |
114 | Q>* | No |
ClinGen Ensembl |
|
| TCGA novel | 114 | Q>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1382743070 CA347104039 |
114 | Q>H | No |
ClinGen gnomAD |
|
| TCGA novel | 128 | Q>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1480274583 CA347103522 |
137 | I>M | No |
ClinGen gnomAD |
|
| TCGA novel | 141 | D>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1267247255 CA347103404 |
142 | K>E | No |
ClinGen gnomAD |
|
|
rs1467270891 CA347103278 |
146 | G>E | No |
ClinGen TOPMed |
|
|
rs778295413 CA49414753 |
149 | S>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs763680917 CA1689852 |
155 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA49412301 rs866164378 |
158 | G>V | No |
ClinGen Ensembl |
|
|
CA347102422 rs1191668444 |
164 | K>R | No |
ClinGen gnomAD |
|
|
rs898922297 CA49412300 |
165 | K>Q | No |
ClinGen Ensembl |
|
| TCGA novel | 165 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
No associated diseases with P63098
5 regional properties for P63098
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EF-hand domain | 22 - 85 | IPR002048-1 |
| domain | EF-hand domain | 87 - 163 | IPR002048-2 |
| binding_site | EF-Hand 1, calcium-binding site | 63 - 75 | IPR018247-1 |
| binding_site | EF-Hand 1, calcium-binding site | 100 - 112 | IPR018247-2 |
| binding_site | EF-Hand 1, calcium-binding site | 141 - 153 | IPR018247-3 |
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| calcineurin complex | A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| parallel fiber to Purkinje cell synapse | An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells. |
| postsynapse | The part of a synapse that is part of the post-synaptic cell. |
| protein serine/threonine phosphatase complex | A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. |
| sarcolemma | The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. |
| Schaffer collateral - CA1 synapse | A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| calcium-dependent protein serine/threonine phosphatase activity | Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions. |
| calcium-dependent protein serine/threonine phosphatase regulator activity | Binds to and modulates of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| cyclosporin A binding | Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids. |
| phosphatase binding | Binding to a phosphatase. |
| protein domain specific binding | Binding to a specific domain of a protein. |
17 GO annotations of biological process
| Name | Definition |
|---|---|
| branching involved in blood vessel morphogenesis | The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. |
| calcineurin-mediated signaling | Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression. |
| calcineurin-NFAT signaling cascade | Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+). |
| epithelial to mesenchymal transition | A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. |
| heart development | The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
| lung epithelial cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung. |
| myelination in peripheral nervous system | The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. |
| negative regulation of calcium ion import across plasma membrane | Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import across plasma membrane. |
| negative regulation of voltage-gated calcium channel activity | Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated calcium channel activity. |
| positive regulation of calcineurin-NFAT signaling cascade | Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade. |
| positive regulation of calcium ion import across plasma membrane | Any process that activates or increases the frequency, rate or extent of calcium ion import across plasma membrane. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| positive regulation of voltage-gated calcium channel activity | Any process that activates or increases the frequency, rate or extent of voltage-gated calcium channel activity. |
| postsynaptic modulation of chemical synaptic transmission | Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission. |
| protein dephosphorylation | The process of removing one or more phosphoric residues from a protein. |
| protein import into nucleus | The directed movement of a protein from the cytoplasm to the nucleus. |
| regulation of postsynaptic neurotransmitter receptor internalization | Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P63099 | PPP3R1 | Calcineurin subunit B type 1 | Bos taurus (Bovine) | PR |
| A0AVX7 | TESC | Calcineurin B homologous protein 3 | Gallus gallus (Chicken) | PR |
| Q96BS2 | TESC | Calcineurin B homologous protein 3 | Homo sapiens (Human) | PR |
| Q96LZ3 | PPP3R2 | Calcineurin subunit B type 2 | Homo sapiens (Human) | PR |
| Q9JKL5 | Tesc | Calcineurin B homologous protein 3 | Mus musculus (Mouse) | PR |
| Q63810 | Ppp3r1 | Calcineurin subunit B type 1 | Mus musculus (Mouse) | PR |
| P28470 | Ppp3r2 | Calcineurin subunit B type 2 | Rattus norvegicus (Rat) | PR |
| P63100 | Ppp3r1 | Calcineurin subunit B type 1 | Rattus norvegicus (Rat) | PR |
| Q75KU4 | CBL4 | Calcineurin B-like protein 4 | Oryza sativa subsp japonica (Rice) | PR |
| Q7XC27 | CBL1 | Calcineurin B-like protein 1 | Oryza sativa subsp japonica (Rice) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGNEASYPLE | MCSHFDADEI | KRLGKRFKKL | DLDNSGSLSV | EEFMSLPELQ | QNPLVQRVID |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IFDTDGNGEV | DFKEFIEGVS | QFSVKGDKEQ | KLRFAFRIYD | MDKDGYISNG | ELFQVLKMMV |
| 130 | 140 | 150 | 160 | ||
| GNNLKDTQLQ | QIVDKTIINA | DKDGDGRISF | EEFCAVVGGL | DIHKKMVVDV |