Q9JKL5
PR
Gene name |
Tesc (Chp3) |
Protein name |
Calcineurin B homologous protein 3 |
Names |
Tescalcin, TE-1, TSC |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:57816 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9JKL5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JKL5-F1 | Predicted | AlphaFoldDB |
8 variants for Q9JKL5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388787205 | 36 | S>C | No | EVA | |
| rs13468968 | 97 | P>S | No | EVA | |
| rs3388790832 | 113 | E>K | No | EVA | |
| rs3388787216 | 121 | M>I | No | EVA | |
| rs3388777980 | 137 | N>S | No | EVA | |
| rs3388777994 | 138 | V>G | No | EVA | |
| rs3388786845 | 169 | C>Y | No | EVA | |
| rs3388774726 | 170 | V>M | No | EVA |
No associated diseases with Q9JKL5
1 regional properties for Q9JKL5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Timeless, N-terminal | 37 - 305 | IPR006906 |
Functions
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| lamellipodium | A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| ruffle | Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. |
| ruffle membrane | The portion of the plasma membrane surrounding a ruffle. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| phosphatase inhibitor activity | Binds to and stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| protein kinase inhibitor activity | Binds to and stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein. |
15 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to retinoic acid | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. |
| cellular sodium ion homeostasis | Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell. |
| male gonad development | The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. |
| megakaryocyte differentiation | The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. |
| negative regulation of cell population proliferation | Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of granulocyte differentiation | Any process that activates or increases the frequency, rate or extent of granulocyte differentiation. |
| positive regulation of megakaryocyte differentiation | Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation. |
| positive regulation of sodium:proton antiporter activity | Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
| protein maturation | Any process leading to the attainment of the full functional capacity of a protein. |
| protein stabilization | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of cell adhesion mediated by integrin | Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P63099 | PPP3R1 | Calcineurin subunit B type 1 | Bos taurus (Bovine) | PR |
| A0AVX7 | TESC | Calcineurin B homologous protein 3 | Gallus gallus (Chicken) | PR |
| P63098 | PPP3R1 | Calcineurin subunit B type 1 | Homo sapiens (Human) | PR |
| Q96LZ3 | PPP3R2 | Calcineurin subunit B type 2 | Homo sapiens (Human) | PR |
| Q96BS2 | TESC | Calcineurin B homologous protein 3 | Homo sapiens (Human) | PR |
| Q63810 | Ppp3r1 | Calcineurin subunit B type 1 | Mus musculus (Mouse) | PR |
| P28470 | Ppp3r2 | Calcineurin subunit B type 2 | Rattus norvegicus (Rat) | PR |
| P63100 | Ppp3r1 | Calcineurin subunit B type 1 | Rattus norvegicus (Rat) | PR |
| Q75KU4 | CBL4 | Calcineurin B-like protein 4 | Oryza sativa subsp japonica (Rice) | PR |
| Q7XC27 | CBL1 | Calcineurin B-like protein 1 | Oryza sativa subsp japonica (Rice) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGAAHSASEE | VRELEGKTGF | SSDQIEQLHR | RFKQLSGDQP | TIRKENFNNV | PDLELNPIRS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KIVRAFFDNR | NLRKGSSGLA | DEINFEDFLT | IMSYFRPIDT | TLGEEQVELS | RKEKLKFLFH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MYDSDSDGRI | TLEEYRNVVE | ELLSGNPHIE | KESARSIADG | AMMEAASVCV | GQMEPDQVYE |
| 190 | 200 | 210 | |||
| GITFEDFLKI | WQGIDIETKM | HIRFLNMETI | ALCH |