AiPD: Autoinhibited Protein Database

Q96BS2

Gene name	TESC (CHP3)
Protein name	Calcineurin B homologous protein 3
Names	Tescalcin, TSC
Species	Homo sapiens (Human)
KEGG Pathway	hsa:54997
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-75 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-75 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q96BS2

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q96BS2-F1	Predicted				AlphaFoldDB

189 variants for Q96BS2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA6813672 rs763955929	4	A>S		No	ClinGen ExAC gnomAD
rs1330388595 CA386880400	5	H>P		No	ClinGen TOPMed
CA386880382 rs1402687997	6	S>F		No	ClinGen gnomAD
rs1447697894 CA386880391	6	S>P		No	ClinGen gnomAD
rs1461691193 CA386880363	7	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA386880350 rs1210089651	9	E>Q		No	ClinGen TOPMed
rs1350794264 CA386880336	10	E>K		No	ClinGen gnomAD
rs1167359824 CA386880324	10	E>V		No	ClinGen gnomAD
rs1200612898 CA386880296	13	E>*		No	ClinGen TOPMed
CA386880292 rs1385222105	13	E>G		No	ClinGen gnomAD
rs1182443044 CA386880286	14	L>I		No	ClinGen gnomAD
CA244220252 rs889156996	16	G>D		No	ClinGen TOPMed gnomAD
CA386880255 rs889156996	16	G>V		No	ClinGen TOPMed gnomAD
CA244220223 rs933243321	20	F>L		No	ClinGen Ensembl
rs1402332568 CA386877957	21	S>P		No	ClinGen gnomAD
CA6813659 rs562957217	22	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386877939 rs1322642294	23	D>N		No	ClinGen TOPMed
CA386877923 rs1377820502	24	Q>*		No	ClinGen gnomAD
rs1178083519 CA386877912	25	I>V		No	ClinGen gnomAD
rs758078242 CA6813656	26	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	26	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1194135731 CA386877866	29	H>Y		No	ClinGen gnomAD
CA6813655 rs139715331	30	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1448650121 CA386877852	30	R>W		No	ClinGen gnomAD
TCGA novel	32	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386877808 rs1204603201	34	Q>*		No	ClinGen gnomAD
rs150871128 CA6813654	34	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA244199293 rs964985742	34	Q>R		No	ClinGen TOPMed gnomAD
TCGA novel	37	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1358732920 CA386877737	40	P>S		No	ClinGen TOPMed
rs756764036 CA6813653	43	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA6813652 rs753793791	43	R>H		No	ClinGen ExAC TOPMed gnomAD
CA386877705 rs753793791	43	R>P		No	ClinGen ExAC TOPMed gnomAD
rs1361475410 CA386886398	44	K>E		No	ClinGen gnomAD
CA386886381 rs1205476641	45	E>Q		No	ClinGen TOPMed
CA6813633 rs756125659	48	N>S		No	ClinGen ExAC TOPMed gnomAD
rs752740344 CA6813632	49	N>S		No	ClinGen ExAC gnomAD
CA386886286 rs1481983565	51	P>R		No	ClinGen TOPMed
CA386886267 rs1565963233	52	D>E		No	ClinGen Ensembl
rs1489436586 CA386886247	54	E>V		No	ClinGen TOPMed
CA386886219 rs1565963223	56	N>K		No	ClinGen Ensembl
rs1593000979 CA386886225	56	N>T		No	ClinGen Ensembl
rs1593000968 CA386886196	58	I>T		No	ClinGen Ensembl
CA386886203 rs1238888743	58	I>V		No	ClinGen gnomAD
CA244231808 rs772915105	59	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs772915105 CA386886190	59	R>G		No	ClinGen gnomAD
rs759291720 CA6813630	60	S>F		No	ClinGen ExAC gnomAD
CA6813629 rs751766984	64	R>C	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA386886132 rs751766984	64	R>G		No	ClinGen ExAC TOPMed gnomAD
rs762965516 CA6813627	64	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs762965516 CA6813628	64	R>L		No	ClinGen ExAC gnomAD
rs984324209 CA244231800	65	A>D		No	ClinGen Ensembl
TCGA novel	67	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1243111559 CA386886076	68	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA386886074 rs1243111559	68	D>Y		No	ClinGen TOPMed gnomAD
rs769031004	69	N>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs777050049 CA6813623	69	N>I		No	ClinGen ExAC gnomAD
CA386886047 rs1307838890	70	R>T		No	ClinGen TOPMed
CA6813602 rs201966544	73	R>C		No	ClinGen ExAC TOPMed gnomAD
CA6813601 rs761040708	73	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA386885172 rs761040708	73	R>L		No	ClinGen ExAC TOPMed gnomAD
rs772630732 CA6813599	75	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA386885135 rs1282977807	76	P>A		No	ClinGen TOPMed gnomAD
CA6813598 rs748927568	76	P>L		No	ClinGen ExAC TOPMed gnomAD
CA386885132 rs748927568	76	P>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	76	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386885125 rs1379302890	77	S>N		No	ClinGen TOPMed
rs373277209 CA6813597	81	D>E		No	ClinGen 1000Genomes ExAC gnomAD
CA6813594 rs148314787	83	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA386885045 rs1397237846	83	I>T		No	ClinGen TOPMed
rs374122867 CA6813590	86	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA6813591 rs374122867	86	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs201789594 CA244226701	92	M>T		No	ClinGen TOPMed
CA6813586 rs530406783	92	M>V		No	ClinGen 1000Genomes ExAC gnomAD
rs753875219 CA6813584	94	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs761081800 CA6813582	95	F>V		No	ClinGen ExAC gnomAD
CA6813580 rs143285421	96	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA6813581 rs776122247	96	R>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	97	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772952061 CA6813578	98	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6813576 rs138273556	99	D>N	Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs899479719 CA386884925	102	M>L		No	ClinGen Ensembl
CA244226631 rs1040734474	102	M>T		No	ClinGen Ensembl
rs899479719 CA244226636	102	M>V		No	ClinGen Ensembl
rs746893667 CA386884912	103	D>E		No	ClinGen ExAC TOPMed gnomAD
CA244226628 rs936468673	103	D>G		No	ClinGen TOPMed
rs925126653 CA244226622	104	E>D		No	ClinGen TOPMed
rs780004006 CA6813572	104	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs868535508 CA244226621	105	E>K		No	ClinGen Ensembl
TCGA novel	105	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386884888 rs1257675529	107	V>M		No	ClinGen gnomAD
CA386884884 rs1315809414	108	E>K		No	ClinGen gnomAD
CA244226615 rs867618785	110	S>F		No	ClinGen Ensembl
CA6813570 rs745683243	111	R>W		No	ClinGen ExAC TOPMed gnomAD
rs370536389 CA6813567	115	L>V		No	ClinGen ESP TOPMed gnomAD
CA386884830 rs1356571074	116	R>K		No	ClinGen TOPMed gnomAD
TCGA novel	118	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1374801232 CA386884284	120	H>Y		No	ClinGen gnomAD
CA386884271 rs1456360728	121	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1286637130 CA386884273	121	M>T		No	ClinGen TOPMed gnomAD
rs1406415180 CA386884264	122	Y>C		No	ClinGen gnomAD
CA244224899 rs984014236	123	D>E		No	ClinGen TOPMed gnomAD
CA386884257 rs1376870774	123	D>G		No	ClinGen gnomAD
CA6813534 rs147019006	123	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA386884252 rs1430269462	124	S>A		No	ClinGen gnomAD
rs200823726 CA244224894	124	S>L		No	ClinGen gnomAD
CA6813532 rs531621385	126	S>G		No	ClinGen ExAC TOPMed gnomAD
CA244224867 rs1034267173	126	S>N		No	ClinGen TOPMed gnomAD
rs749129728 CA6813530	127	D>N		No	ClinGen ExAC TOPMed gnomAD
rs979997799 CA244224849	129	R>C		No	ClinGen TOPMed gnomAD
CA386884212 rs1294729983	129	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA386884190 rs1406341196	132	L>V		No	ClinGen gnomAD
CA6813527 rs748445499	133	E>G		No	ClinGen ExAC TOPMed gnomAD
CA386884155 rs867356353	136	R>*		No	ClinGen gnomAD
rs867356353 CA386884156	136	R>G		No	ClinGen gnomAD
CA386884154 rs1401185009	136	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs555980740 CA6813506	138	V>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1307209643 CA386884109	139	V>I		No	ClinGen gnomAD
CA6813504 rs780369862	140	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1408826705 CA386884073	144	S>L		No	ClinGen gnomAD
rs1592992900 CA386884063	146	N>T		No	ClinGen Ensembl
rs1444915306 CA386884057	147	P>A		No	ClinGen TOPMed
rs1468827483 CA386884050	148	H>Y		No	ClinGen gnomAD
CA386884044 rs1200661508	149	I>V		No	ClinGen gnomAD
TCGA novel	150	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1267460547 CA386884036	150	E>K		No	ClinGen TOPMed gnomAD
rs1450476499 CA386884012	153	S>P		No	ClinGen TOPMed gnomAD
rs150127766 CA386884006	154	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6813500 rs150127766	154	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1326703975 CA386884005	154	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1037089879 CA244224672	155	R>C		No	ClinGen TOPMed gnomAD
rs1419833739 CA386884000	155	R>H		No	ClinGen TOPMed gnomAD
CA386883987 rs1347309919	157	I>T		No	ClinGen gnomAD
CA386883980 rs1345822964	158	A>G		No	ClinGen gnomAD
rs1435681467 CA386883984	158	A>T		No	ClinGen gnomAD
rs767179467 CA6813498	159	D>N		No	ClinGen ExAC gnomAD
CA386883971 rs1478846854	160	G>R		No	ClinGen gnomAD
CA386883955 rs1177594526	162	M>T		No	ClinGen gnomAD
CA386883958 rs1477285323	162	M>V		No	ClinGen TOPMed
rs1592992763 CA386883946	163	M>R		No	ClinGen Ensembl
rs754426994 CA6813497	164	E>D		No	ClinGen ExAC gnomAD
CA6813496 rs751083650	165	A>V		No	ClinGen ExAC TOPMed gnomAD
CA386883928 rs1592992739	166	A>P		No	ClinGen Ensembl
rs1467667160 CA386883921	167	S>C		No	ClinGen TOPMed
rs116635547 RCV000947497 CA6813495	168	V>M		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA244224621 rs915869036	170	M>T		No	ClinGen gnomAD
rs1217367624 CA386883900	170	M>V		No	ClinGen gnomAD
rs1487427305 CA386883892	171	G>W		No	ClinGen gnomAD
CA386883888 rs1303040219	172	Q>*		No	ClinGen TOPMed
CA244224584 rs1022242256	173	M>I		No	ClinGen TOPMed gnomAD
rs993052189 CA244224599	173	M>L		No	ClinGen Ensembl
CA6813478 rs779591817	174	E>K		No	ClinGen ExAC gnomAD
CA6813477 rs190403622	175	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs915745893 CA244220796	176	D>G		No	ClinGen Ensembl
rs1248353515 CA386882901	176	D>H		No	ClinGen gnomAD
CA386882885 rs1320131082	177	Q>*		No	ClinGen gnomAD
CA386882881 rs1320131082	177	Q>K		No	ClinGen gnomAD
CA6813476 rs750330523	177	Q>R		No	ClinGen ExAC
CA386882870 rs1167073338	178	V>M		No	ClinGen gnomAD
rs761646501 CA244220789	180	E>*		No	ClinGen ExAC gnomAD
rs761646501 CA6813474	180	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1409728508 CA386882819	181	G>E		No	ClinGen gnomAD
TCGA novel	182	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	182	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386882811 rs1366777444	182	I>V		No	ClinGen gnomAD
CA6813473 rs553226423	183	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386882770 rs1163546143	185	E>K		No	ClinGen gnomAD
CA6813471 rs760939477	186	D>V		No	ClinGen ExAC gnomAD
TCGA novel	187	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775624203 CA6813470	188	L>P		No	ClinGen ExAC gnomAD
CA386882719 rs1482687257	189	K>E		No	ClinGen gnomAD
rs1475002035 CA386881820	190	I>T		No	ClinGen TOPMed gnomAD
rs1456410191 CA386881813	191	W>G		No	ClinGen gnomAD
CA386881810 rs1456410191	191	W>R		No	ClinGen gnomAD
rs1174154937 CA386881778	193	G>E		No	ClinGen gnomAD
CA6813449 rs774410585	193	G>R		No	ClinGen ExAC gnomAD
CA6813446 rs773745110	195	D>G		No	ClinGen ExAC gnomAD
CA6813447 rs763426115	195	D>N		No	ClinGen ExAC TOPMed gnomAD
CA386881722 rs1592986158	198	T>P		No	ClinGen Ensembl
CA386881678 rs1483634632	201	H>Y		No	ClinGen gnomAD
rs748479607 CA6813444	202	V>I		No	ClinGen ExAC gnomAD
rs779702836 CA6813443	203	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA386881649 rs1199135761	203	R>H		No	ClinGen gnomAD
CA386881629 rs1252348326	205	L>F		No	ClinGen gnomAD
rs369376430 CA6813441	207	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1592986104 CA386881574	209	T>P		No	ClinGen Ensembl
CA6813440 rs547087823	211	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1278670181 CA386881500	214	H>Q		No	ClinGen TOPMed
rs911443927 CA244218427	214	H>R		No	ClinGen TOPMed gnomAD

No associated diseases with Q96BS2

No regional properties for Q96BS2

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q96BS2

Functions

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm Membrane ; Lipid-anchor Cell membrane Cell projection, lamellipodium Cell projection, ruffle membrane	Colocalizes with SLC9A1 at the plasma membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
lamellipodium	A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
ruffle	Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
ruffle membrane	The portion of the plasma membrane surrounding a ruffle.

5 GO annotations of molecular function

Name	Definition
calcium ion binding	Binding to a calcium ion (Ca2+).
magnesium ion binding	Binding to a magnesium (Mg) ion.
phosphatase inhibitor activity	Binds to and stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
protein kinase inhibitor activity	Binds to and stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein.

14 GO annotations of biological process

Name	Definition
cellular response to retinoic acid	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
male gonad development	The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
megakaryocyte differentiation	The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte.
negative regulation of cell population proliferation	Any process that stops, prevents or reduces the rate or extent of cell proliferation.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of granulocyte differentiation	Any process that activates or increases the frequency, rate or extent of granulocyte differentiation.
positive regulation of megakaryocyte differentiation	Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.
positive regulation of sodium:proton antiporter activity	Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
protein localization to plasma membrane	A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
protein maturation	Any process leading to the attainment of the full functional capacity of a protein.
protein stabilization	Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of cell adhesion mediated by integrin	Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin.

10 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P63099	PPP3R1	Calcineurin subunit B type 1	Bos taurus (Bovine)	PR
A0AVX7	TESC	Calcineurin B homologous protein 3	Gallus gallus (Chicken)	PR
P63098	PPP3R1	Calcineurin subunit B type 1	Homo sapiens (Human)	PR
Q96LZ3	PPP3R2	Calcineurin subunit B type 2	Homo sapiens (Human)	PR
Q63810	Ppp3r1	Calcineurin subunit B type 1	Mus musculus (Mouse)	PR
Q9JKL5	Tesc	Calcineurin B homologous protein 3	Mus musculus (Mouse)	PR
P28470	Ppp3r2	Calcineurin subunit B type 2	Rattus norvegicus (Rat)	PR
P63100	Ppp3r1	Calcineurin subunit B type 1	Rattus norvegicus (Rat)	PR
Q75KU4	CBL4	Calcineurin B-like protein 4	Oryza sativa subsp japonica (Rice)	PR
Q7XC27	CBL1	Calcineurin B-like protein 1	Oryza sativa subsp japonica (Rice)	PR

10	20	30	40	50	60
MGAAHSASEE	VRELEGKTGF	SSDQIEQLHR	RFKQLSGDQP	TIRKENFNNV	PDLELNPIRS
70	80	90	100	110	120
KIVRAFFDNR	NLRKGPSGLA	DEINFEDFLT	IMSYFRPIDT	TMDEEQVELS	RKEKLRFLFH
130	140	150	160	170	180
MYDSDSDGRI	TLEEYRNVVE	ELLSGNPHIE	KESARSIADG	AMMEAASVCM	GQMEPDQVYE
190	200	210
GITFEDFLKI	WQGIDIETKM	HVRFLNMETM	ALCH