Q2TBI5

PR
Gene name
PPP3R2
Protein name
Calcineurin subunit B type 2
Names
Protein phosphatase 2B regulatory subunit 2, Protein phosphatase 3 regulatory subunit B beta isoform
Species
Bos taurus (Bovine)
KEGG Pathway
bta:617585
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-75 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2TBI5

Entry ID Method Resolution Chain Position Source
AF-Q2TBI5-F1 Predicted AlphaFoldDB

No variants for Q2TBI5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2TBI5

No associated diseases with Q2TBI5

5 regional properties for Q2TBI5

Type Name Position InterPro Accession
domain TRAM domain 430 - 492 IPR002792
domain Elp3/MiaA/NifB-like, radical SAM core domain 202 - 421 IPR006638
domain Radical SAM 199 - 442 IPR007197
domain Methylthiotransferase, N-terminal 63 - 171 IPR013848
conserved_site Methylthiotransferase, conserved site 207 - 227 IPR020612

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
  • Localizes in the mitochondria in a SPATA33-dependent manner
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
calcineurin complex A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
calcium-dependent protein serine/threonine phosphatase regulator activity Binds to and modulates of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase.
phosphatase binding Binding to a phosphatase.

2 GO annotations of biological process

Name Definition
calcineurin-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression.
protein dephosphorylation The process of removing one or more phosphoric residues from a protein.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P63099 PPP3R1 Calcineurin subunit B type 1 Bos taurus (Bovine) PR
Q96LZ3 PPP3R2 Calcineurin subunit B type 2 Homo sapiens (Human) PR
P28470 Ppp3r2 Calcineurin subunit B type 2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MGNEASYPAE ICSHFDEDEI KRLRKRFKKL DLDSSSALSV KEFTSMPELQ ENPLVQRVID
70 80 90 100 110 120
VFDTDGDGQV DFREFILGTS QFSVRGDEEQ KLRFAFSIYD MDKDGYISNG ELFQVLKMMV
130 140 150 160
GDNLKDWQLQ QLVDKTIILL DKDGDGKISF QEFSAVVRSL EIHKHLVTIV