P05750

PR
Gene name
RPS3
Protein name
40S ribosomal protein S3
Names
RP13, Small ribosomal subunit protein uS3, YS3
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YNL178W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

165-240 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

97 structures for P05750

Entry ID Method Resolution Chain Position Source
3J6X EM 610 A S3 1-240 PDB
3J6Y EM 610 A S3 1-240 PDB
3J77 EM 620 A S3 1-240 PDB
3J78 EM 630 A S3 1-240 PDB
4BSZ X-ray 284 A A 1-240 PDB
4U3M X-ray 300 A S3/s3 2-240 PDB
4U3N X-ray 320 A S3/s3 2-240 PDB
4U3U X-ray 290 A S3/s3 2-240 PDB
4U4N X-ray 310 A S3/s3 2-240 PDB
4U4O X-ray 360 A S3/s3 2-240 PDB
4U4Q X-ray 300 A S3/s3 2-240 PDB
4U4R X-ray 280 A S3/s3 2-240 PDB
4U4U X-ray 300 A S3/s3 2-240 PDB
4U4Y X-ray 320 A S3/s3 2-240 PDB
4U4Z X-ray 310 A S3/s3 2-240 PDB
4U50 X-ray 320 A S3/s3 2-240 PDB
4U51 X-ray 320 A S3/s3 2-240 PDB
4U52 X-ray 300 A S3/s3 2-240 PDB
4U53 X-ray 330 A S3/s3 2-240 PDB
4U55 X-ray 320 A S3/s3 2-240 PDB
4U56 X-ray 345 A S3/s3 2-240 PDB
4U6F X-ray 310 A S3/s3 2-240 PDB
4V4B EM 1170 A AC 2-193 PDB
4V6I EM 880 A AB 1-240 PDB
4V7R X-ray 400 A AC/CC 1-240 PDB
4V88 X-ray 300 A AD/CD 1-240 PDB
4V8Y EM 430 A AD 1-240 PDB
4V8Z EM 660 A AD 1-240 PDB
4V92 EM 370 A D 4-225 PDB
5DAT X-ray 315 A S3/s3 2-240 PDB
5DC3 X-ray 325 A S3/s3 2-240 PDB
5DGE X-ray 345 A S3/s3 2-240 PDB
5DGF X-ray 330 A S3/s3 2-240 PDB
5DGV X-ray 310 A S3/s3 2-240 PDB
5FCI X-ray 340 A S3/s3 2-240 PDB
5FCJ X-ray 310 A S3/s3 2-240 PDB
5I4L X-ray 310 A S3/s3 3-225 PDB
5JUO EM 400 A AB 1-240 PDB
5JUP EM 350 A AB 1-240 PDB
5JUS EM 420 A AB 1-240 PDB
5JUT EM 400 A AB 1-240 PDB
5JUU EM 400 A AB 1-240 PDB
5LYB X-ray 325 A S3/s3 3-225 PDB
5M1J EM 330 A D2 3-225 PDB
5MC6 EM 380 A A 1-240 PDB
5MEI X-ray 350 A E/s3 3-225 PDB
5NDG X-ray 370 A S3/s3 3-225 PDB
5NDV X-ray 330 A S3/s3 3-225 PDB
5NDW X-ray 370 A S3/s3 3-225 PDB
5OBM X-ray 340 A S3/s3 3-225 PDB
5ON6 X-ray 310 A E/s3 3-225 PDB
5TBW X-ray 300 A E/s3 3-225 PDB
5TGA X-ray 330 A S3/s3 3-225 PDB
5TGM X-ray 350 A S3/s3 3-225 PDB
6FAI EM 340 A D 1-240 PDB
6GQ1 EM 440 A t 3-225 PDB
6GQB EM 390 A t 3-225 PDB
6GQV EM 400 A t 3-225 PDB
6HHQ X-ray 310 A E/s3 1-240 PDB
6I7O EM 530 A A/Ab 3-225 PDB
6Q8Y EM 310 A A 3-225 PDB
6RBD EM 347 A D 1-240 PDB
6RBE EM 380 A D 1-240 PDB
6S47 EM 328 A BE 2-240 PDB
6SNT EM 280 A D 1-240 PDB
6SV4 EM 330 A A/Ab/Ac 1-240 PDB
6T4Q EM 260 A SD 4-225 PDB
6T7I EM 320 A SD 1-240 PDB
6T7T EM 310 A SD 1-240 PDB
6T83 EM 400 A Db/e 1-240 PDB
6TB3 EM 280 A A 4-225 PDB
6TNU EM 310 A A 4-225 PDB
6WDR EM 370 A D 3-225 PDB
6WOO EM 290 A DD 3-225 PDB
6Z6J EM 340 A SD 1-240 PDB
6Z6K EM 340 A SD 1-240 PDB
6ZCE EM 530 A E 1-240 PDB
6ZU9 EM 620 A B 1-240 PDB
6ZVI EM 300 A l 3-225 PDB
7A1G EM 300 A A 4-225 PDB
7B7D EM 330 A A 4-225 PDB
7MPI EM 305 A BD 3-225 PDB
7MPJ EM 270 A BD 3-225 PDB
7N8B EM 305 A BD 3-225 PDB
7NRC EM 390 A SA 4-225 PDB
7NRD EM 436 A SA 3-225 PDB
7ZPQ EM 347 A AD 4-225 PDB
7ZRS EM 480 A AD 4-225 PDB
7ZUW EM 430 A AD 4-225 PDB
7ZUX EM 250 A DD 4-225 PDB
7ZW0 EM 240 A sA 1-240 PDB
8BQD EM 390 A A 4-225 PDB
8BQX EM 380 A A 4-225 PDB
8CAH EM 300 A A 1-240 PDB
8CAS EM 330 A B 1-240 PDB
8CBJ EM 380 A D 1-240 PDB
AF-P05750-F1 Predicted AlphaFoldDB

No variants for P05750

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P05750

No associated diseases with P05750

3 regional properties for P05750

Type Name Position InterPro Accession
domain Ribosomal protein S3, C-terminal 107 - 188 IPR001351
domain K Homology domain, type 2 20 - 93 IPR004044
conserved_site Ribosomal protein S3, conserved site 147 - 183 IPR018280

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
90S preribosome A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
cytosolic small ribosomal subunit The small subunit of a ribosome located in the cytosol.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
preribosome, small subunit precursor A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.

4 GO annotations of molecular function

Name Definition
DNA-(apurinic or apyrimidinic site) endonuclease activity Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER).
protein kinase A catalytic subunit binding Binding to one or both of the catalytic subunits of protein kinase A.
RNA binding Binding to an RNA molecule or a portion thereof.
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.

3 GO annotations of biological process

Name Definition
cytoplasmic translation The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
ribosomal small subunit export from nucleus The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm.
rRNA export from nucleus The directed movement of rRNA from the nucleus to the cytoplasm; the rRNA is usually in the form of ribonucleoproteins.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q06559 RpS3 40S ribosomal protein S3 Drosophila melanogaster (Fruit fly) PR
P23396 RPS3 40S ribosomal protein S3 Homo sapiens (Human) PR
P62908 Rps3 40S ribosomal protein S3 Mus musculus (Mouse) PR
P48152 rps-3 40S ribosomal protein S3 Caenorhabditis elegans PR
Q9FJA6 RPS3C 40S ribosomal protein S3-3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SIP7 RPS3A 40S ribosomal protein S3-1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M339 RPS3B 40S ribosomal protein S3-2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MVALISKKRK LVADGVFYAE LNEFFTRELA EEGYSGVEVR VTPTKTEVII RATRTQDVLG
70 80 90 100 110 120
ENGRRINELT LLVQKRFKYA PGTIVLYAER VQDRGLSAVA QAESMKFKLL NGLAIRRAAY
130 140 150 160 170 180
GVVRYVMESG AKGCEVVVSG KLRAARAKAM KFADGFLIHS GQPVNDFIDT ATRHVLMRQG
190 200 210 220 230
VLGIKVKIMR DPAKSRTGPK ALPDAVTIIE PKEEEPILAP SVKDYRPAEE TEAQAEPVEA