Q9Z1X2
Gene name |
Ptdss2 (Pss2) |
Protein name |
Phosphatidylserine synthase 2 |
Names |
PSS-2, PtdSer synthase 2, Serine-exchange enzyme II |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:27388 |
EC number |
2.7.8.29: Transferases for other substituted phosphate groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9Z1X2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Z1X2-F1 | Predicted | AlphaFoldDB |
24 variants for Q9Z1X2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388954362 | 49 | I>V | No | EVA | |
| rs3388943092 | 56 | Y>C | No | EVA | |
| rs3388943135 | 90 | A>T | No | EVA | |
| rs3388962373 | 91 | K>N | No | EVA | |
| rs3388916228 | 101 | A>T | No | EVA | |
| rs3388965530 | 104 | R>L | No | EVA | |
| rs3398217401 | 138 | R>S | No | EVA | |
| rs3388953718 | 184 | L>P | No | EVA | |
| rs3388961848 | 199 | S>C | No | EVA | |
| rs3388965582 | 206 | E>D | No | EVA | |
| rs3388916175 | 208 | S>I | No | EVA | |
| rs864267052 | 240 | M>V | No | EVA | |
| rs3388953786 | 309 | T>N | No | EVA | |
| rs3388930914 | 325 | V>I | No | EVA | |
| rs3388943115 | 341 | R>G | No | EVA | |
| rs3388962192 | 394 | W>* | No | EVA | |
| rs3388930921 | 399 | I>F | No | EVA | |
| rs3388965561 | 407 | W>R | No | EVA | |
| rs3388953773 | 424 | Q>* | No | EVA | |
| rs3388953733 | 427 | Q>H | No | EVA | |
| rs219811596 | 437 | R>G | No | EVA | |
| rs3388961909 | 455 | E>V | No | EVA | |
| rs3388953707 | 467 | E>G | No | EVA | |
| rs3388954312 | 472 | A>V | No | EVA |
No associated diseases with Q9Z1X2
No regional properties for Q9Z1X2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9Z1X2 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.8.29 | Transferases for other substituted phosphate groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| CDP-diacylglycerol-serine O-phosphatidyltransferase activity | Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine. |
| L-serine-phosphatidylethanolamine phosphatidyltransferase activity | Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine <=> L-1-phosphatidylserine + ethanolamine. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphatidylserine biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2KHY9 | PTDSS1 | Phosphatidylserine synthase 1 | Bos taurus (Bovine) | PR |
| Q5ZM65 | PTDSS1 | Phosphatidylserine synthase 1 | Gallus gallus (Chicken) | PR |
| E1BYA3 | PTDSS1 | Phosphatidylserine synthase 2 | Gallus gallus (Chicken) | PR |
| P48651 | PTDSS1 | Phosphatidylserine synthase 1 | Homo sapiens (Human) | PR |
| Q99LH2 | Ptdss1 | Phosphatidylserine synthase 1 | Mus musculus (Mouse) | PR |
| Q5PQL5 | Ptdss1 | Phosphatidylserine synthase 1 | Rattus norvegicus (Rat) | PR |
| Q5N8Q3 | PSS3 | CDP-diacylglycerol--serine O-phosphatidyltransferase 3 | Oryza sativa subsp japonica (Rice) | PR |
| Q6I628 | PSS2 | CDP-diacylglycerol--serine O-phosphatidyltransferase 2 | Oryza sativa subsp japonica (Rice) | PR |
| F4HXY7 | PSS1 | CDP-diacylglycerol--serine O-phosphatidyltransferase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q08D11 | ptdss2 | Phosphatidylserine synthase 2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| E7EY42 | ptdss2 | Phosphatidylserine synthase 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRRGERRVAG | GSGSESPLLK | GRRSTESEVY | DDGTNTFFWR | AHTLTVLFIL | TCALGYVTLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EETPQDTAYN | TKRGIVASIL | VFLCFGVTQA | KDGPFSRPHP | AYWRFWLCVS | VVYELFLIFI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LFQTVQDGRQ | FLKYVDPRLG | VPLPERDYGG | NCLIYDADNK | TDPFHNIWDK | LDGFVPAHFI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GWYLKTLMIR | DWWMCMIISV | MFEFLEYSLE | HQLPNFSECW | WDHWIMDVLV | CNGLGIYCGM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KTLEWLSLKT | YKWQGLWNIP | TYKGKMKRIA | FQFTPYSWVR | FEWKPASSLH | RWLAVCGIIL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VFLLAELNTF | YLKFVLWMPP | EHYLVLLRLV | FFVNVGGVAM | REIYDFMDEL | KPHRKLGQQA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| WLVAAITVTE | LLIVVKYDPH | TLTLSLPFYI | SQCWTLGSIL | VLTWTVWRFF | LRDITMRYKE |
| 430 | 440 | 450 | 460 | 470 | |
| TRRQKQQSHQ | ARAVNNRDGH | PGPDDDLLGT | GTAEEEGTTN | DGVTAEEGTS | AAS |