Q2KHY9

PR
Gene name
PTDSS1
Protein name
Phosphatidylserine synthase 1
Names
PSS-1, PtdSer synthase 1, Serine-exchange enzyme I
Species
Bos taurus (Bovine)
KEGG Pathway
bta:509819
EC number
2.7.8.29: Transferases for other substituted phosphate groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

410-473 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2KHY9

Entry ID Method Resolution Chain Position Source
AF-Q2KHY9-F1 Predicted AlphaFoldDB

62 variants for Q2KHY9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs443691320 2 A>G No EVA
rs476866854 3 S>A No EVA
rs476866854 3 S>P No EVA
rs455114092 5 V>G No EVA
rs443187454 10 L>P No EVA
rs472889189 11 S>R No EVA
rs454371562 14 D>E No EVA
rs431964196 15 V>L No EVA
rs798435325 55 Y>F No EVA
rs455230852 71 R>T No EVA
rs440204027 74 L>R No EVA
rs464211506 94 T>P No EVA
rs481982334 97 H>N No EVA
rs463641170 97 H>Q No EVA
rs448350680 100 L>V No EVA
rs480711861 104 V>G No EVA
rs466210059 148 E>A No EVA
rs454409998 150 A>S No EVA
rs432696549 154 H>Y No EVA
rs450281609 186 Y>F No EVA
rs482748086 194 I>V No EVA
rs467306635 195 T>A No EVA
rs478402677 199 T>S No EVA
rs453403659 202 F>L No EVA
rs454596774 205 H>R No EVA
rs468514210 209 N>K No EVA
rs446989332 220 L>V No EVA
rs434771407 230 I>L No EVA
rs464600954 233 G>V No EVA
rs482538059 242 M>R No EVA
rs463918004 243 R>W No EVA
rs448708507 246 H>R No EVA
rs481065369 249 S>R No EVA
rs466556985 255 T>S No EVA
rs469273709 291 Y>* No EVA
rs480399647 294 M>L No EVA
rs479166374 295 I>M No EVA
rs449342164 295 I>N No EVA
rs468402385 295 I>V No EVA
rs438788649 297 W>L No EVA
rs460514983 297 W>R No EVA
rs436052155 340 A>D No EVA
rs465830189 346 Q>H No EVA
rs435449316 430 W>L No EVA
rs452938798 438 G>D No EVA
rs464308970 440 E>G No EVA
rs434481957 440 E>K No EVA
rs481656830 441 D>G No EVA
rs469885003 442 G>V No EVA
rs475426143 444 H>P No EVA
rs475426143 444 H>R No EVA
rs440445206 452 S>G No EVA
rs479963188 455 S>C No EVA
rs439616511 458 R>S No EVA
rs475828679 459 N>D No EVA
rs464025801 460 R>G No EVA
rs442359368 461 H>P No EVA
rs475152741 464 S>L No EVA
rs435014320 466 V>A No EVA
rs453436719 466 V>F No EVA
rs470655798 467 T>S No EVA
rs436728080 472 K>R No EVA

No associated diseases with Q2KHY9

2 regional properties for Q2KHY9

Type Name Position InterPro Accession
repeat Pentatricopeptide repeat 254 - 297 IPR002885-1
repeat Pentatricopeptide repeat 331 - 382 IPR002885-2

Functions

Description
EC Number 2.7.8.29 Transferases for other substituted phosphate groups
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
  • Highly enriched in the mitochondria-associated membrane (MAM)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
L-serine-phosphatidylcholine phosphatidyltransferase activity Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline.
L-serine-phosphatidylethanolamine phosphatidyltransferase activity Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine <=> L-1-phosphatidylserine + ethanolamine.

1 GO annotations of biological process

Name Definition
phosphatidylserine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
E1BYA3 PTDSS1 Phosphatidylserine synthase 2 Gallus gallus (Chicken) PR
Q5ZM65 PTDSS1 Phosphatidylserine synthase 1 Gallus gallus (Chicken) PR
P48651 PTDSS1 Phosphatidylserine synthase 1 Homo sapiens (Human) PR
Q9Z1X2 Ptdss2 Phosphatidylserine synthase 2 Mus musculus (Mouse) PR
Q99LH2 Ptdss1 Phosphatidylserine synthase 1 Mus musculus (Mouse) PR
Q5PQL5 Ptdss1 Phosphatidylserine synthase 1 Rattus norvegicus (Rat) PR
Q6I628 PSS2 CDP-diacylglycerol--serine O-phosphatidyltransferase 2 Oryza sativa subsp japonica (Rice) PR
Q5N8Q3 PSS3 CDP-diacylglycerol--serine O-phosphatidyltransferase 3 Oryza sativa subsp japonica (Rice) PR
F4HXY7 PSS1 CDP-diacylglycerol--serine O-phosphatidyltransferase 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q08D11 ptdss2 Phosphatidylserine synthase 2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
E7EY42 ptdss2 Phosphatidylserine synthase 2 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MASCVGSRTL SKDDVNYKMH FRMINEQQVE DITIDFFYRP HTITLLSFTI VSLMYFAFTR
70 80 90 100 110 120
DDSVPEDNIW RGILSVIFFF LIISVLAFPN GPFTRPHPAL WRMVFGLSVL YFLFLVFLLF
130 140 150 160 170 180
LNFEQVKSLM YWLDPNLRYA TREADVMEYA VNCHVITWER IISHFDIFAF GHFWGWAMKA
190 200 210 220 230 240
LLIRSYGLCW TISITWELTE LFFMHLLPNF AECWWDQVIL DILLCNGGGI WLGMVVCRFL
250 260 270 280 290 300
EMRTYHWASF KDIHTTTGKI KRAVLQFTPA SWTYVRWFDP KSSFQRVAGI YLFMIIWQLT
310 320 330 340 350 360
ELNTFFLKHI FVFQASHPLS WCRILFIGGI TAPTVRQYYA YLTDTQCKRV GTQCWVFGVI
370 380 390 400 410 420
GFLEAIVCIK FGQDLFSKTQ ILYVVLWLLC VAFTTFLCLY GMVWYAEHYG HREKTYSECE
430 440 450 460 470
DGTYSPDISW PHGKGSKGSE DGPHKHPGNS ESHSSRRRNR HSKSKVTNGV GKK