Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q5N8Q3

Entry ID Method Resolution Chain Position Source
AF-Q5N8Q3-F1 Predicted AlphaFoldDB

No variants for Q5N8Q3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5N8Q3

No associated diseases with Q5N8Q3

No regional properties for Q5N8Q3

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5N8Q3

Functions

Description
EC Number 2.7.8.8 Transferases for other substituted phosphate groups
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
CDP-diacylglycerol-serine O-phosphatidyltransferase activity Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine.
L-serine-phosphatidylethanolamine phosphatidyltransferase activity Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine <=> L-1-phosphatidylserine + ethanolamine.

2 GO annotations of biological process

Name Definition
phosphatidylethanolamine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
phosphatidylserine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KHY9 PTDSS1 Phosphatidylserine synthase 1 Bos taurus (Bovine) PR
E1BYA3 PTDSS1 Phosphatidylserine synthase 2 Gallus gallus (Chicken) PR
Q5ZM65 PTDSS1 Phosphatidylserine synthase 1 Gallus gallus (Chicken) PR
P48651 PTDSS1 Phosphatidylserine synthase 1 Homo sapiens (Human) PR
Q9Z1X2 Ptdss2 Phosphatidylserine synthase 2 Mus musculus (Mouse) PR
Q99LH2 Ptdss1 Phosphatidylserine synthase 1 Mus musculus (Mouse) PR
Q5PQL5 Ptdss1 Phosphatidylserine synthase 1 Rattus norvegicus (Rat) PR
Q6I628 PSS2 CDP-diacylglycerol--serine O-phosphatidyltransferase 2 Oryza sativa subsp japonica (Rice) PR
F4HXY7 PSS1 CDP-diacylglycerol--serine O-phosphatidyltransferase 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q08D11 ptdss2 Phosphatidylserine synthase 2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
E7EY42 ptdss2 Phosphatidylserine synthase 2 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MPVRRRWYPP SSTAAQPSPD GGDVNTDDAD ACPSSRQQRP PSLPQHSAPI HHRRRVINSI
70 80 90 100 110 120
DASGEVMEYG SSNDQRMQDM EIWPSDGGGV EEYDPWTAWL YKPHTVSVLL AGACLLIWAS
130 140 150 160 170 180
GVLHPEITSS HDKVIPIKRG VWAMIAVFLA YCTLQAPSTI LIRPHPAVWR LVHGMAVVYL
190 200 210 220 230 240
VALTFLLFQK RDDARQFMKH LHPGLGVELP ERSYGSDCRM YVPENPTNRF INIQETLFDE
250 260 270 280 290 300
FVIAHVLGWW GKAVMIRNQL LLWVLSVGFE LMELTFRHML PNFNECWWDS IILDIMICNW
310 320 330 340 350 360
FGIWAGMHTV RYFDGKTYEW VGLSRQPSIM GKVKRSLCQF TPAKWDKDQW HPFMEPRRFI
370 380 390 400 410
QVFCLCVGFM TVELNTFFLK FCLWIPPRNP LVVYRLILWW LIAIPAIREY NTYLQDRSS