Q5PQL5
Gene name |
Ptdss1 |
Protein name |
Phosphatidylserine synthase 1 |
Names |
PSS-1, PtdSer synthase 1, Serine-exchange enzyme I |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:314553 |
EC number |
2.7.8.29: Transferases for other substituted phosphate groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5PQL5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5PQL5-F1 | Predicted | AlphaFoldDB |
2 variants for Q5PQL5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3321048846 | 468 | N>S | No | EVA | |
| rs3321147600 | 473 | K>E | No | EVA |
No associated diseases with Q5PQL5
No regional properties for Q5PQL5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q5PQL5 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.8.29 | Transferases for other substituted phosphate groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| L-serine-phosphatidylcholine phosphatidyltransferase activity | Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline. |
| L-serine-phosphatidylethanolamine phosphatidyltransferase activity | Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine <=> L-1-phosphatidylserine + ethanolamine. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphatidylserine biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2KHY9 | PTDSS1 | Phosphatidylserine synthase 1 | Bos taurus (Bovine) | PR |
| E1BYA3 | PTDSS1 | Phosphatidylserine synthase 2 | Gallus gallus (Chicken) | PR |
| Q5ZM65 | PTDSS1 | Phosphatidylserine synthase 1 | Gallus gallus (Chicken) | PR |
| P48651 | PTDSS1 | Phosphatidylserine synthase 1 | Homo sapiens (Human) | PR |
| Q9Z1X2 | Ptdss2 | Phosphatidylserine synthase 2 | Mus musculus (Mouse) | PR |
| Q99LH2 | Ptdss1 | Phosphatidylserine synthase 1 | Mus musculus (Mouse) | PR |
| Q6I628 | PSS2 | CDP-diacylglycerol--serine O-phosphatidyltransferase 2 | Oryza sativa subsp japonica (Rice) | PR |
| Q5N8Q3 | PSS3 | CDP-diacylglycerol--serine O-phosphatidyltransferase 3 | Oryza sativa subsp japonica (Rice) | PR |
| F4HXY7 | PSS1 | CDP-diacylglycerol--serine O-phosphatidyltransferase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q08D11 | ptdss2 | Phosphatidylserine synthase 2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| E7EY42 | ptdss2 | Phosphatidylserine synthase 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASCVGSRTL | SKDDVNYRMH | FRMINEQQVE | DITIDFFYRP | HTITLLSFTI | ISLMYFAFTR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DDCVPEDNIW | RGILSVIFFF | LIISVLAFPN | GPFTRPHPAL | WRMVFGLSVL | YFLFLVFLLF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LNFEQVKSLM | YWLDPNLRYA | TREADIMEYA | VNCHVITWER | IVSHFDIFAF | GHFWGWAMKA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LLIRSYGLCW | TISITWELTE | LFFMHLLPNF | AECWWDQVIL | DILLCNGGGI | WLGMVVCRFL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EMRTYHWASF | KDIHTTTGKI | KRAVLQFTPA | SWTYVRWFDP | KSSFQRVAGI | YLFMIIWQLT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ELNTFFLKHI | FVFQASHPLS | WCRILFIGCI | TAPTVRQYYA | YLTDTQCKRV | GTQCWVFGVI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GFLEAIVCIK | FGQDLFSKTQ | ILYVVLWLLC | VAFTTFLCLY | GMVWYAEHYG | HREKTYSECE |
| 430 | 440 | 450 | 460 | 470 | |
| DGTYSPEISW | YHGKGSKGSE | DSPPKHSNNN | ESHSSRRRNR | HSKSKVTNGV | GKK |