E7EY42

PR
Gene name
ptdss2 (si:ch1073-158c2, si:ch1073-279O1)
Protein name
Phosphatidylserine synthase 2
Names
PSS-2, PtdSer synthase 2, Serine-exchange enzyme II
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:100004136
EC number
2.7.8.29: Transferases for other substituted phosphate groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

392-452 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for E7EY42

Entry ID Method Resolution Chain Position Source
AF-E7EY42-F1 Predicted AlphaFoldDB

No variants for E7EY42

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for E7EY42

No associated diseases with E7EY42

No regional properties for E7EY42

Type Name Position InterPro Accession
No domain, repeats, and functional sites for E7EY42

Functions

Description
EC Number 2.7.8.29 Transferases for other substituted phosphate groups
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
  • Highly enriched in the mitochondria-associated membrane (MAM)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
L-serine-phosphatidylethanolamine phosphatidyltransferase activity Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine <=> L-1-phosphatidylserine + ethanolamine.

1 GO annotations of biological process

Name Definition
phosphatidylserine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KHY9 PTDSS1 Phosphatidylserine synthase 1 Bos taurus (Bovine) PR
Q5ZM65 PTDSS1 Phosphatidylserine synthase 1 Gallus gallus (Chicken) PR
E1BYA3 PTDSS1 Phosphatidylserine synthase 2 Gallus gallus (Chicken) PR
P48651 PTDSS1 Phosphatidylserine synthase 1 Homo sapiens (Human) PR
Q99LH2 Ptdss1 Phosphatidylserine synthase 1 Mus musculus (Mouse) PR
Q9Z1X2 Ptdss2 Phosphatidylserine synthase 2 Mus musculus (Mouse) PR
Q5PQL5 Ptdss1 Phosphatidylserine synthase 1 Rattus norvegicus (Rat) PR
Q6I628 PSS2 CDP-diacylglycerol--serine O-phosphatidyltransferase 2 Oryza sativa subsp japonica (Rice) PR
Q5N8Q3 PSS3 CDP-diacylglycerol--serine O-phosphatidyltransferase 3 Oryza sativa subsp japonica (Rice) PR
F4HXY7 PSS1 CDP-diacylglycerol--serine O-phosphatidyltransferase 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q08D11 ptdss2 Phosphatidylserine synthase 2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MAKGEWKRSG ADDLPLPGRS ECEVFDDGTN TFFWRAHTVT VLFILTCALV YVTLLEETPH
70 80 90 100 110 120
DTAYNTKRGI VASILVFLCF GVTQAKDGPF TRPHPAYWRF WLCVSVVYEL FLIFILFQTV
130 140 150 160 170 180
HDGRQFMKYI DPKLGVPLPE RGYGGNCLIY DPGHPTDPFH NIWDKMDGFV PAHFLGWYIK
190 200 210 220 230 240
TLMIRDWWMC MIISVMFEFL EYSLEHQLPN FSECWWDHWI MDVLVCNGLG IYCGMKTLGW
250 260 270 280 290 300
LSMKPYQWQG LWNIPTYKGK IKRIAFQFTP YSWVKFEWRP ASNLRRWLAV LGIIFMFLLA
310 320 330 340 350 360
ELNTFYLKFV MWMPPEHYLV LFRLVFFVNV GGVAMREIYD FMDDPKFHKK LGQQAWIVAA
370 380 390 400 410 420
ITVTEFLIVV KYDPNTIMLP IPFFITQCWI LGIALILVWT LWRFFIRDIT LRYKETRRRR
430 440 450
QEVSSERDGS SSAPSGRSKL NGSMDSVRHR KS