AiPD: Autoinhibited Protein Database

Q9Y305

Gene name	ACOT9 (CGI-16)
Protein name	Acyl-coenzyme A thioesterase 9, mitochondrial
Names	Acyl-CoA thioesterase 9, Acyl-CoA thioester hydrolase 9
Species	Homo sapiens (Human)
KEGG Pathway	hsa:23597
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

29-112 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

29-112 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9Y305

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9Y305-F1	Predicted				AlphaFoldDB

247 variants for Q9Y305

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1404424947 CA412523419	3	R>L		No	ClinGen TOPMed
CA412523331 rs1189637599	11	L>F		No	ClinGen TOPMed
rs1256837953 CA412523325	12	G>D		No	ClinGen TOPMed gnomAD
CA10369800 rs538861399	13	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs778461458 CA10369799	15	Q>K		No	ClinGen ExAC gnomAD
CA412523308 rs1158970276	15	Q>P		No	ClinGen TOPMed
CA412523290 rs1283144799	18	P>A		No	ClinGen gnomAD
CA326900381 rs867714025	18	P>L		No	ClinGen Ensembl
CA412523280 rs1455392573	20	R>G		No	ClinGen TOPMed
TCGA novel	21	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412523252 rs1171915804	24	Q>R		No	ClinGen TOPMed
rs900903489 CA326900379	25	G>E		No	ClinGen TOPMed gnomAD
rs756755942 CA10369798	26	P>S		No	ClinGen ExAC gnomAD
rs753522285 CA10369797	27	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs753522285 CA326900378	27	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs1338300052 CA412523236	27	Q>R		No	ClinGen gnomAD
TCGA novel	30	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	34	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs996269447 CA326900370	34	I>N		No	ClinGen TOPMed
rs372732121 CA10369792	35	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1279067875 CA412523165	37	I>F		No	ClinGen TOPMed
rs1179693816 CA412523159	38	H>D		No	ClinGen gnomAD
CA10369764 rs745706448	41	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs774209507 CA10369763	42	D>G		No	ClinGen ExAC TOPMed gnomAD
CA326895260 rs201594302	45	R>Q		No	ClinGen 1000Genomes gnomAD
rs770734260 CA10369762	45	R>W		No	ClinGen ExAC TOPMed gnomAD
CA412523015 rs1601820803	47	I>L		No	ClinGen Ensembl
rs1258282542 CA412523010	47	I>M		No	ClinGen TOPMed
TCGA novel	52	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10369746 rs760955811	56	D>H		No	ClinGen ExAC gnomAD
CA412522923 rs1480987235	58	V>A		No	ClinGen gnomAD
CA10369745 rs368046594	60	A>T		No	ClinGen ESP ExAC gnomAD
CA10369744 rs770810094	61	M>V		No	ClinGen ExAC gnomAD
CA10369743 rs35412966	63	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs747602291 CA10369739	68	H>Q		No	ClinGen ExAC gnomAD
TCGA novel	70	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750690372 CA10369738	74	S>P		No	ClinGen 1000Genomes ExAC gnomAD
rs1203987335 CA412522800	76	D>N		No	ClinGen gnomAD
rs768158515 CA10369737	77	G>A		No	ClinGen ExAC gnomAD
TCGA novel	79	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780255334 CA10369735	80	P>S		No	ClinGen ExAC gnomAD
CA412522742 rs758833744	84	K>N		No	ClinGen ExAC TOPMed gnomAD
rs750959048 CA10369733	85	D>H		No	ClinGen ExAC gnomAD
rs1569197131 CA412522729	86	S>T		No	ClinGen Ensembl
CA874052032 rs1397633494	87	Y>*		No	ClinGen TOPMed
rs1200833894 CA412522722	87	Y>C		No	ClinGen gnomAD
TCGA novel	88	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	95	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	96	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1334167234 CA412522659	96	S>N		No	ClinGen gnomAD
rs1334167234 CA412522661	96	S>T		No	ClinGen gnomAD
rs1328443992 CA412522655	97	E>Q		No	ClinGen gnomAD
rs34081355 CA10369731	99	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA412522642 rs1470476076	99	E>K		No	ClinGen gnomAD
rs753902242 CA10369730	101	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1469714654 COSM1119363 CA412522617	102	E>D	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
TCGA novel	103	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764265019 CA10369729	104	Y>C		No	ClinGen ExAC gnomAD
rs1285226875 CA412522600	105	L>V		No	ClinGen TOPMed
rs375503606 CA10369727	111	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA412522529 rs1163742058	114	G>R		No	ClinGen gnomAD
rs779423852 CA10369713	118	E>Q		No	ClinGen ExAC gnomAD
CA326894126 rs916955976	119	D>N		No	ClinGen TOPMed
CA10369699 rs760288281	130	M>L		No	ClinGen ExAC gnomAD
rs370320089 CA10369696	137	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs370320089 COSM388018 CA10369697	137	A>S	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs774808141 CA10369695	139	M>I		No	ClinGen ExAC gnomAD
CA412522341 rs1318969210	139	M>L		No	ClinGen TOPMed
rs1269532183 CA412522337	139	M>T		No	ClinGen gnomAD
CA412522325 rs1490868329	141	P>S		No	ClinGen TOPMed gnomAD
TCGA novel	143	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753582234 CA10369693	144	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1298170493 CA412522298	145	V>A		No	ClinGen gnomAD
rs756594878 CA10369691	147	A>T		No	ClinGen ExAC gnomAD
CA326932079 rs1052466974	149	V>M		No	ClinGen TOPMed gnomAD
rs1363140150 CA412522273	150	D>A		No	ClinGen gnomAD
rs1363140150 CA412522272	150	D>G		No	ClinGen gnomAD
CA10369689 rs781165058	150	D>N		No	ClinGen ExAC TOPMed gnomAD
CA10369688 rs755148226	151	K>E		No	ClinGen ExAC gnomAD
TCGA novel	152	I>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10369681 rs775024112	154	M>V		No	ClinGen ExAC gnomAD
rs1225854366 CA412522218	156	K>E		No	ClinGen gnomAD
rs767157676 CA412522198	158	S>I		No	ClinGen ExAC TOPMed gnomAD
CA10369680 rs767157676	158	S>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	161	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412522162 rs1299968848	163	Q>R		No	ClinGen gnomAD
CA412522148 rs1391472375	165	I>V		No	ClinGen gnomAD
CA10369678 rs774215042	168	S>G		No	ClinGen ExAC gnomAD
CA412522115 rs1464825575	169	G>D		No	ClinGen TOPMed gnomAD
rs372565091 CA10369677	170	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA412522076 rs1377012657 COSM252319	175	G>R	ovary [Cosmic]	No	ClinGen cosmic curated gnomAD
rs770460708 CA326931907	178	S>F		No	ClinGen Ensembl
rs1176976482 CA412522020	183	M>L		No	ClinGen gnomAD
TCGA novel	183	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs141129259 CA10369672	185	M>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs767053132 CA10369673	185	M>L		No	ClinGen 1000Genomes ExAC gnomAD
CA10369651 rs148179443	189	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1487177391 CA412521945	191	D>E		No	ClinGen gnomAD
rs1180937597 CA412521941	192	E>*		No	ClinGen TOPMed
CA10369650 rs186269629	193	F>L		No	ClinGen 1000Genomes ExAC gnomAD
CA10369649 rs746100629	195	P>L		No	ClinGen ExAC gnomAD
rs376691316 CA10369647	198	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1165911729 CA412521868	203	M>V		No	ClinGen TOPMed
rs1018918932 CA326928991	205	A>P		No	ClinGen gnomAD
rs1339630137 CA412521849	206	R>C		No	ClinGen TOPMed gnomAD
CA326928984 rs888996533	209	E>K		No	ClinGen Ensembl
rs752666995 CA10369646	211	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1419646911 CA412521811	211	K>T		No	ClinGen TOPMed
CA412521807 rs1473598181	212	G>R		No	ClinGen gnomAD
rs769087648 CA412521783	213	P>L		No	ClinGen ExAC gnomAD
CA10369636 rs769087648	213	P>R		No	ClinGen ExAC gnomAD
CA326927236 rs887299794	214	A>V		No	ClinGen Ensembl
rs761203603 CA10369635	218	P>A		No	ClinGen ExAC TOPMed gnomAD
CA10369634 rs371687278	218	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	218	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772093546 CA10369633	221	P>S		No	ClinGen ExAC gnomAD
CA10369632 rs746072190	225	E>G		No	ClinGen ExAC gnomAD
TCGA novel	227	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412521653 rs1272425042	229	L>R		No	ClinGen gnomAD
rs779061907 CA10369630	231	R>K		No	ClinGen ExAC gnomAD
rs771196737 CA10369629	232	Q>*		No	ClinGen ExAC gnomAD
rs1330240709 CA412521626	233	G>A		No	ClinGen TOPMed
TCGA novel	234	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412521599 rs1170493568	235	L>F		No	ClinGen gnomAD
CA10369613 rs377512509	236	N>K		No	ClinGen ESP ExAC gnomAD
rs759475709 CA10369612	237	K>E		No	ClinGen ExAC gnomAD
CA412521581 rs1477424365	238	G>E		No	ClinGen gnomAD
rs1233044460 CA412521560	241	I>T		No	ClinGen gnomAD
rs771016382 CA10369610	242	A>V		No	ClinGen ExAC gnomAD
CA10369608 rs200394258	245	S>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA412521531 rs1204079022	246	T>A		No	ClinGen gnomAD
CA10369607 COSM457273 rs201643422	246	T>M	breast [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs977020326 CA326926842	247	S>L		No	ClinGen TOPMed gnomAD
TCGA novel	250	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1217499273 CA412521505	250	K>R		No	ClinGen gnomAD
CA326926839 rs965586685	252	A>S		No	ClinGen TOPMed gnomAD
rs746934885 CA10369606	254	S>I		No	ClinGen ExAC gnomAD
rs139220036 CA10369604	255	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1375028862 CA412521442	259	T>I		No	ClinGen gnomAD
rs1453839883 CA412521433	261	I>V		No	ClinGen gnomAD
rs1167627113 CA412521427	262	H>Y		No	ClinGen TOPMed
rs763233076	272	K>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA412521354 rs1174597443	272	K>E		No	ClinGen gnomAD
rs763233076 CA10369592	272	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1293605231 CA412521325	274	I>T		No	ClinGen TOPMed
CA412521330 rs1232484345	274	I>V		No	ClinGen TOPMed
rs181259615 COSM1119359 CA10369589	277	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs146707213 CA10369590	277	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs199997116 CA10369588	279	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA10369587 rs775363617	279	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1601802648 TCGA novel CA412521260	285	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
CA412521251 rs1411351125	286	V>E		No	ClinGen TOPMed gnomAD
CA412521252 rs1411351125	286	V>G		No	ClinGen TOPMed gnomAD
rs771866596 CA412521254	286	V>L		No	ClinGen ExAC TOPMed gnomAD
CA10369586 rs771866596	286	V>M		No	ClinGen ExAC TOPMed gnomAD
rs745841905 CA10369585	289	E>G		No	ClinGen ExAC TOPMed gnomAD
rs778266632 CA10369584	291	S>A		No	ClinGen ExAC gnomAD
CA10369583 rs770469845	294	K>*		No	ClinGen ExAC gnomAD
CA10369582 rs376686410	296	L>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA412521175 rs1437997685	297	E>K		No	ClinGen gnomAD
rs1487359975 CA412521153	300	H>D		No	ClinGen TOPMed gnomAD
CA412521141 rs1285459105	301	P>L		No	ClinGen gnomAD
rs1006552919 CA326926517	302	Q>*		No	ClinGen gnomAD
CA412521137 rs1347718298	302	Q>R		No	ClinGen gnomAD
CA412521121 rs56378612	303	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10369568 rs56378612	303	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs774413488 CA10369566	304	R>G		No	ClinGen ExAC gnomAD
rs770414891 CA10369565	304	R>Q		No	ClinGen ExAC TOPMed gnomAD
VAR_062668	305	N>H	a pancreatic ductal adenocarcinoma sample; somatic mutation [UniProt]	No	UniProt
rs1260439845 CA412521088	308	N>H		No	ClinGen gnomAD
TCGA novel	308	N>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748728551 CA10369564	308	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10369563 rs777295122	309	R>W		No	ClinGen ExAC gnomAD
rs866345123 CA326926445	312	G>C		No	ClinGen Ensembl
rs1388014459 CA412521054	313	G>D		No	ClinGen gnomAD
rs1393408320 CA412521056	313	G>S		No	ClinGen TOPMed
CA412521033 rs1434177050	316	M>T		No	ClinGen TOPMed
TCGA novel	317	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10369562 rs756321106	319	A>D		No	ClinGen ExAC
CA412521000 rs1442544837	320	Y>*		No	ClinGen gnomAD
rs769386063 CA10369560	323	A>S		No	ClinGen ExAC gnomAD
rs747881458 CA10369559	323	A>V		No	ClinGen ExAC gnomAD
rs1266923738 CA412520979	324	W>G		No	ClinGen gnomAD
rs1198932801 CA412520968	325	A>G		No	ClinGen gnomAD
CA412520966 rs1408022107	326	T>A		No	ClinGen TOPMed
CA412520962 rs1327893930	326	T>S		No	ClinGen TOPMed
TCGA novel	331	G>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412520910 rs1279995181	332	G>S		No	ClinGen gnomAD
CA10369549 rs754131492	333	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs767212027 CA10369548	334	R>*		No	ClinGen ExAC gnomAD
CA10369547 rs774135140	334	R>P		No	ClinGen ExAC gnomAD
rs774135140 CA10369546	334	R>Q		No	ClinGen ExAC gnomAD
CA10369544 rs184948673	335	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs770815402 CA10369545	335	P>S		No	ClinGen ExAC gnomAD
rs769331024 CA10369542	338	V>L		No	ClinGen ExAC gnomAD
rs747749361 CA10369541	341	D>G		No	ClinGen ExAC TOPMed gnomAD
rs768203608 CA10369539	343	I>F		No	ClinGen ExAC gnomAD
CA10369540 rs768203608	343	I>V		No	ClinGen ExAC gnomAD
rs1400208304 CA412520844	344	M>V		No	ClinGen TOPMed gnomAD
CA412520825 rs1318617883	346	Q>*		No	ClinGen TOPMed
TCGA novel	348	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10369538 rs747334721	351	V>I		No	ClinGen ExAC TOPMed gnomAD
CA412520765 rs1291748536	355	L>F		No	ClinGen TOPMed
rs112579683 CA326926262	356	F>L		No	ClinGen Ensembl
rs981542197 CA326926250	359	S>L		No	ClinGen Ensembl
rs781695729 CA10369536	360	Q>E		No	ClinGen 1000Genomes ExAC gnomAD
rs1007388568 CA326926182	361	V>I		No	ClinGen Ensembl
CA412520690 rs1359620323	365	Q>E		No	ClinGen gnomAD
CA10369523 rs773196927	368	Y>C		No	ClinGen ExAC gnomAD
rs1432429086 CA412520645	371	V>I		No	ClinGen TOPMed
rs761324862 CA412520623	374	H>P		No	ClinGen ExAC gnomAD
CA10369521 rs761324862	374	H>R		No	ClinGen ExAC gnomAD
CA10369520 rs776012511	375	S>R		No	ClinGen ExAC TOPMed gnomAD
CA326926137 rs1022030175	378	A>V		No	ClinGen Ensembl
rs147682207 CA10369519	379	S>C		No	ClinGen ESP ExAC gnomAD
CA326926118 rs765970167	381	Q>*		No	ClinGen TOPMed gnomAD
TCGA novel	384	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs988066103 CA326926115	385	H>R		No	ClinGen TOPMed
CA10369517 rs763824834	386	T>A		No	ClinGen 1000Genomes ExAC gnomAD
rs368644186 CA10369516	386	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA10369514 rs779621905	389	N>D		No	ClinGen ExAC gnomAD
rs140445911 CA10369513	393	F>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA10369511 rs777736551	394	T>M		No	ClinGen ExAC TOPMed gnomAD
rs777736551 CA10369512	394	T>R		No	ClinGen ExAC TOPMed gnomAD
rs1052010652 CA326926078	397	S>L		No	ClinGen TOPMed gnomAD
rs756334925 CA10369510	399	K>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	405	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10369508 rs766154649	408	T>I		No	ClinGen ExAC gnomAD
rs761691139 CA326925702	412	S>C		No	ClinGen ExAC TOPMed gnomAD
rs761691139 CA10369504	412	S>F		No	ClinGen ExAC TOPMed gnomAD
CA412520331 rs1255429952	415	Y>*		No	ClinGen TOPMed
CA412520305 rs1276318446	419	Q>R		No	ClinGen gnomAD
rs13497 CA326925686	420	R>L		No	ClinGen ExAC TOPMed gnomAD
rs13497 CA10369502	420	R>P		No	ClinGen ExAC TOPMed gnomAD
rs13497 CA10369501	420	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA10369503 rs776162907	420	R>W		No	ClinGen ExAC gnomAD
CA10369499 rs774409265	423	N>H		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	425	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA326925673 rs201105808	426	S>N		No	ClinGen 1000Genomes TOPMed gnomAD
rs1158935743 CA412520262	426	S>R		No	ClinGen TOPMed
CA10369498 rs200042097	429	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs774584941 CA10369497	430	T>S		No	ClinGen ExAC gnomAD
CA412520201 rs1478081237	435	Y>H		No	ClinGen gnomAD
rs1402145115 CA412520193	436	L>F		No	ClinGen TOPMed
CA412520189 rs1196267982	437	V>L		No	ClinGen gnomAD
CA412520183 rs1450745691	438	E>K		No	ClinGen gnomAD
rs749809021 CA10369495	439	P>S		No	ClinGen ExAC gnomAD

No associated diseases with Q9Y305

3 regional properties for Q9Y305

Type	Name	Position	InterPro Accession
domain	Oxoglutarate/iron-dependent dioxygenase	175 - 280	IPR005123
domain	Non-haem dioxygenase N-terminal domain	25 - 93	IPR026992
domain	Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain	177 - 279	IPR044861

Functions

		Description
EC Number
Subcellular Localization	Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
mitochondrial matrix	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name	Definition
acetyl-CoA hydrolase activity	Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+).
acyl-CoA hydrolase activity	Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.
carboxylic ester hydrolase activity	Catalysis of the hydrolysis of a carboxylic ester bond.
palmitoyl-CoA hydrolase activity	Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate.

1 GO annotations of biological process

Name	Definition
acyl-CoA metabolic process	The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.

10 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3SWX2	ACOT9	Acyl-coenzyme A thioesterase 9, mitochondrial	Bos taurus (Bovine)	PR
Q8WYK0	ACOT12	Acetyl-coenzyme A thioesterase	Homo sapiens (Human)	PR
O00154	ACOT7	Cytosolic acyl coenzyme A thioester hydrolase	Homo sapiens (Human)	PR
Q9DBK0	Acot12	Acetyl-coenzyme A thioesterase	Mus musculus (Mouse)	PR
Q91V12	Acot7	Cytosolic acyl coenzyme A thioester hydrolase	Mus musculus (Mouse)	PR
Q8VHQ9	Acot11	Acyl-coenzyme A thioesterase 11	Mus musculus (Mouse)	PR
Q32MW3	Acot10	Acyl-coenzyme A thioesterase 10, mitochondrial	Mus musculus (Mouse)	PR
Q9R0X4	Acot9	Acyl-coenzyme A thioesterase 9, mitochondrial	Mus musculus (Mouse)	PR
Q64559	Acot7	Cytosolic acyl coenzyme A thioester hydrolase	Rattus norvegicus (Rat)	PR
Q99NB7	Acot12	Acetyl-coenzyme A thioesterase	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MRRAALRLCA	LGKGQLTPGR	GLTQGPQNPK	KQGIFHIHEV	RDKLREIVGA	STNWRDHVKA
70	80	90	100	110	120
MEERKLLHSF	LAKSQDGLPP	RRMKDSYIEV	LLPLGSEPEL	REKYLTVQNT	VRFGRILEDL
130	140	150	160	170	180
DSLGVLICYM	HNKIHSAKMS	PLSIVTALVD	KIDMCKKSLS	PEQDIKFSGH	VSWVGKTSME
190	200	210	220	230	240
VKMQMFQLHG	DEFCPVLDAT	FVMVARDSEN	KGPAFVNPLI	PESPEEEELF	RQGELNKGRR
250	260	270	280	290	300
IAFSSTSLLK	MAPSAEERTT	IHEMFLSTLD	PKTISFRSRV	LPSNAVWMEN	SKLKSLEICH
310	320	330	340	350	360
PQERNIFNRI	FGGFLMRKAY	ELAWATACSF	GGSRPFVVAV	DDIMFQKPVE	VGSLLFLSSQ
370	380	390	400	410	420
VCFTQNNYIQ	VRVHSEVASL	QEKQHTTTNV	FHFTFMSEKE	VPLVFPKTYG	ESMLYLDGQR
430
HFNSMSGPAT	LRKDYLVEP