Q3SWX2
Gene name |
ACOT9 |
Protein name |
Acyl-coenzyme A thioesterase 9, mitochondrial |
Names |
Acyl-CoA thioesterase 9, Acyl-CoA thioester hydrolase 9 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:527845 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3SWX2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3SWX2-F1 | Predicted | AlphaFoldDB |
82 variants for Q3SWX2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs432338814 | 7 | R>G | No | EVA | |
| rs477644081 | 8 | L>H | No | EVA | |
| rs441466990 | 11 | L>M | No | EVA | |
| rs460069112 | 11 | L>Q | No | EVA | |
| rs481400006 | 13 | K>M | No | EVA | |
| rs482356418 | 19 | S>R | No | EVA | |
| rs470276831 | 19 | S>T | No | EVA | |
| rs446135787 | 20 | R>G | No | EVA | |
| rs465076053 | 23 | T>P | No | EVA | |
| rs432177174 | 24 | Q>R | No | EVA | |
| rs459564942 | 25 | E>V | No | EVA | |
| rs453905516 | 26 | S>P | No | EVA | |
| rs454422983 | 30 | E>G | No | EVA | |
| rs476102188 | 33 | F>C | No | EVA | |
| rs476102188 | 33 | F>S | No | EVA | |
| rs443255369 | 34 | H>P | No | EVA | |
| rs471142374 | 37 | E>G | No | EVA | |
| rs462649547 | 55 | H>L | No | EVA | |
| rs444941409 | 56 | V>L | No | EVA | |
| rs460532477 | 60 | E>K | No | EVA | |
| rs449461123 | 63 | K>N | No | EVA | |
| rs467942228 | 66 | H>P | No | EVA | |
| rs437968347 | 67 | S>I | No | EVA | |
| rs450048865 | 70 | A>P | No | EVA | |
| rs432434125 | 72 | S>P | No | EVA | |
| rs473164240 | 85 | Y>* | No | EVA | |
| rs433776524 | 87 | E>A | No | EVA | |
| rs455611419 | 88 | V>I | No | EVA | |
| rs474141846 | 91 | P>H | No | EVA | |
| rs462485017 | 98 | L>* | No | EVA | |
| rs471409510 | 98 | L>F | No | EVA | |
| rs438455821 | 101 | K>* | No | EVA | |
| rs381380917 | 108 | T>S | No | EVA | |
| rs478999402 | 109 | V>E | No | EVA | |
| rs460092612 | 109 | V>L | No | EVA | |
| rs481475758 | 111 | F>V | No | EVA | |
| rs456354882 | 119 | D>E | No | EVA | |
| rs465300064 | 120 | S>R | No | EVA | |
| rs431951083 | 122 | G>R | No | EVA | |
| rs481890912 | 125 | I>N | No | EVA | |
| rs445707903 | 126 | C>Y | No | EVA | |
| rs464287289 | 128 | M>L | No | EVA | |
| rs434974357 | 136 | K>E | No | EVA | |
| rs453571312 | 139 | P>L | No | EVA | |
| rs468780999 | 140 | L>S | No | EVA | |
| rs435837498 | 147 | V>L | No | EVA | |
| rs457583597 | 149 | K>N | No | EVA | |
| rs444311778 | 162 | D>V | No | EVA | |
| rs456164995 | 192 | S>A | No | EVA | |
| rs455423942 | 203 | A>D | No | EVA | |
| rs453234647 | 214 | V>E | No | EVA | |
| rs441550627 | 214 | V>L | No | EVA | |
| rs475033455 | 215 | N>T | No | EVA | |
| rs442076534 | 216 | P>Q | No | EVA | |
| rs482605531 | 217 | L>P | No | EVA | |
| rs458663454 | 218 | I>F | No | EVA | |
| rs447498382 | 219 | L>F | No | EVA | |
| rs465749627 | 220 | E>* | No | EVA | |
| rs465749627 | 220 | E>K | No | EVA | |
| rs448152182 | 223 | E>K | No | EVA | |
| rs469914845 | 225 | E>D | No | EVA | |
| rs437384245 | 226 | E>K | No | EVA | |
| rs452691065 | 230 | Q>* | No | EVA | |
| rs464764335 | 231 | G>V | No | EVA | |
| rs435050088 | 233 | L>V | No | EVA | |
| rs470587040 | 233 | L>W | No | EVA | |
| rs441020618 | 234 | N>S | No | EVA | |
| rs474868329 | 242 | S>C | No | EVA | |
| rs474868329 | 242 | S>G | No | EVA | |
| rs441912062 | 245 | S>* | No | EVA | |
| rs463322684 | 249 | M>I | No | EVA | |
| rs481834340 | 252 | T>S | No | EVA | |
| rs445749124 | 256 | R>G | No | EVA | |
| rs457862869 | 266 | T>S | No | EVA | |
| rs441860183 | 273 | S>G | No | EVA | |
| rs457264118 | 298 | H>P | No | EVA | |
| rs466993945 | 324 | T>N | No | EVA | |
| rs469134711 | 379 | Q>R | No | EVA | |
| rs482418389 | 412 | L>S | No | EVA | |
| rs449553709 | 413 | Y>S | No | EVA | |
| rs464802386 | 421 | K>T | No | EVA | |
| rs432032912 | 436 | E>D | No | EVA |
No associated diseases with Q3SWX2
2 regional properties for Q3SWX2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Hotdog acyl-CoA thioesterase (ACOT)-type domain | 84 - 207 | IPR033120-1 |
| domain | Hotdog acyl-CoA thioesterase (ACOT)-type domain | 287 - 399 | IPR033120-2 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| acyl-CoA hydrolase activity | Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate. |
| carboxylic ester hydrolase activity | Catalysis of the hydrolysis of a carboxylic ester bond. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| acyl-CoA metabolic process | The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8WYK0 | ACOT12 | Acetyl-coenzyme A thioesterase | Homo sapiens (Human) | PR |
| O00154 | ACOT7 | Cytosolic acyl coenzyme A thioester hydrolase | Homo sapiens (Human) | PR |
| Q9Y305 | ACOT9 | Acyl-coenzyme A thioesterase 9, mitochondrial | Homo sapiens (Human) | PR |
| Q9DBK0 | Acot12 | Acetyl-coenzyme A thioesterase | Mus musculus (Mouse) | PR |
| Q91V12 | Acot7 | Cytosolic acyl coenzyme A thioester hydrolase | Mus musculus (Mouse) | PR |
| Q8VHQ9 | Acot11 | Acyl-coenzyme A thioesterase 11 | Mus musculus (Mouse) | PR |
| Q32MW3 | Acot10 | Acyl-coenzyme A thioesterase 10, mitochondrial | Mus musculus (Mouse) | PR |
| Q9R0X4 | Acot9 | Acyl-coenzyme A thioesterase 9, mitochondrial | Mus musculus (Mouse) | PR |
| Q64559 | Acot7 | Cytosolic acyl coenzyme A thioester hydrolase | Rattus norvegicus (Rat) | PR |
| Q99NB7 | Acot12 | Acetyl-coenzyme A thioesterase | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRRAALRLCT | LSKGLLAPSR | GLTQESQNPE | NVFHIREVRD | KLREIVGAST | NWRDHVKAME |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ERKLLHSFLA | KSQKGLPPRT | MKDSYIEVFL | PLGSQPELRE | KYLTVQNTVR | FGRILEDLDS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LGVLICYMHN | KIHSAKMSPL | SIVTALVDKI | DMCKKNLSPE | QDIKFSGHVS | WVGKTSMEVK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MHMFQLHGND | FSPVLDATFV | MVARDSENKG | PAFVNPLILE | SPEEEELFQQ | GELNKGRRVA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FSSTSLLKMA | PTAEERTTIH | EMFLNTLDPK | TISFRSRVLP | ANSVWMENSK | LKSLDICHPQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ERNIFNRIFG | GFLMRKAYEL | GWATACNFGG | SRPFIVAVDD | IMFQKPVEVG | SLLFLSAQVC |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FTQGNYIQVR | VHSEVASLQD | KEHMTTNVFH | FTFMSEKEVP | LVFPRTYGES | MLYLDGQRHF |
| 430 | |||||
| KSMSAPVTLK | RNYVVEP |