AiPD: Autoinhibited Protein Database

Gene name	Acot11 (Bfit, Thea)
Protein name	Acyl-coenzyme A thioesterase 11
Names	Acyl-CoA thioesterase 11, Acyl-CoA thioester hydrolase 11, Adipose-associated thioesterase, Brown fat-inducible thioesterase, BFIT, Palmitoyl-coenzyme A thioesterase
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:329910
EC number	3.1.2.2: Thiolester hydrolases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-67 (Predicted disordered autoinhibitory region) PR

1-67 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8VHQ9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388699880	9	L>*	No	EVA
rs232228938	34	P>A	No	EVA
rs3388696843	38	A>VSDG*	No	EVA
rs3394649178	48	E>V	No	EVA
rs3394645233	62	H>L	No	EVA
rs3394694697	118	N>H	No	EVA
rs3388685862	169	T>S	No	EVA
rs3388700786	200	C>G	No	EVA
rs3388693648	204	D>V	No	EVA
rs3388694799	222	E>V	No	EVA
rs3388694692	224	V>D	No	EVA
rs3388704085	257	R>Q	No	EVA
rs3388703269	257	R>W	No	EVA
rs3388696906	284	V>M	No	EVA
rs3388700419	286	K>T	No	EVA
rs3388699829	288	I>N	No	EVA
rs3388685875	294	K>M	No	EVA
rs3388691597	301	V>E	No	EVA
rs3388688430	302	C>*	No	EVA
rs3388693626	317	I>V	No	EVA
rs3388685947	342	Q>K	No	EVA
rs3388700764	379	P>H	No	EVA
rs3388703227	380	W>*	No	EVA
rs3388700789	406	V>M	No	EVA
rs3394649187	449	R>S	No	EVA
rs3388704009	458	S>*	No	EVA
rs3388678145	464	Q>*	No	EVA
rs28168845	466	D>Y	No	EVA
rs3388700483	471	I>F	No	EVA
rs3388693641	473	H>R	No	EVA
rs3388698656	475	I>F	No	EVA
rs3388697224	484	K>M	No	EVA
rs3388691601	489	V>L	No	EVA
rs3388697306	520	P>S	No	EVA
rs3388694811	521	E>D	No	EVA
rs3388678185	576	C>R	No	EVA
rs3388699862	581	L>*	No	EVA
rs3388691586	588	A>D	No	EVA
rs3388700436	595	L>L	No	EVA

Type	Name	Position	InterPro Accession
domain	START domain	385 - 583	IPR002913
domain	Thioesterase domain	69 - 135	IPR006683-1
domain	Thioesterase domain	235 - 304	IPR006683-2
domain	Hotdog acyl-CoA thioesterase (ACOT)-type domain	45 - 157	IPR033120-1
domain	Hotdog acyl-CoA thioesterase (ACOT)-type domain	217 - 330	IPR033120-2

		Description
EC Number	3.1.2.2	Thiolester hydrolases
Subcellular Localization	Mitochondrion matrix Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrial matrix	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

Name	Definition
acyl-CoA hydrolase activity	Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.
carboxylic ester hydrolase activity	Catalysis of the hydrolysis of a carboxylic ester bond.
long-chain acyl-CoA hydrolase activity	Catalysis of the reaction: H2O + a long-chain acyl-CoA = a long-chain carboxylate + CoA. A long chain is a chain of greater than 12 carbons in length.
long-chain fatty acyl-CoA binding	Binding to a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.
myristoyl-CoA hydrolase activity	Catalysis of the reaction: myristoyl-CoA + H2O <=> H+ + tetradecanoate + coenzyme A.
palmitoyl-CoA hydrolase activity	Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate.

Name	Definition
acyl-CoA metabolic process	The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.
fatty acid metabolic process	The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of cold-induced thermogenesis	Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
response to cold	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
response to temperature stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3SWX2	ACOT9	Acyl-coenzyme A thioesterase 9, mitochondrial	Bos taurus (Bovine)	PR
O00154	ACOT7	Cytosolic acyl coenzyme A thioester hydrolase	Homo sapiens (Human)	PR
Q9Y305	ACOT9	Acyl-coenzyme A thioesterase 9, mitochondrial	Homo sapiens (Human)	PR
Q8WYK0	ACOT12	Acetyl-coenzyme A thioesterase	Homo sapiens (Human)	PR
Q9R0X4	Acot9	Acyl-coenzyme A thioesterase 9, mitochondrial	Mus musculus (Mouse)	PR
Q32MW3	Acot10	Acyl-coenzyme A thioesterase 10, mitochondrial	Mus musculus (Mouse)	PR
Q9DBK0	Acot12	Acetyl-coenzyme A thioesterase	Mus musculus (Mouse)	PR
Q91V12	Acot7	Cytosolic acyl coenzyme A thioester hydrolase	Mus musculus (Mouse)	PR
Q64559	Acot7	Cytosolic acyl coenzyme A thioester hydrolase	Rattus norvegicus (Rat)	PR
Q99NB7	Acot12	Acetyl-coenzyme A thioesterase	Rattus norvegicus (Rat)	PR