Q32MW3
Gene name |
Acot10 |
Protein name |
Acyl-coenzyme A thioesterase 10, mitochondrial |
Names |
Acyl-CoA thioesterase 10, Mitochondrial 48 kDa acyl-CoA thioester hydrolase 2, Mt-ACT48.2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:64833 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q32MW3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q32MW3-F1 | Predicted | AlphaFoldDB |
37 variants for Q32MW3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3405811882 | 12 | N>I | No | EVA | |
| rs3405965447 | 12 | N>Y | No | EVA | |
| rs3389364782 | 20 | R>G | No | EVA | |
| rs3389275177 | 37 | H>Y | No | EVA | |
| rs218607872 | 41 | V>D | No | EVA | |
| rs244128365 | 49 | I>S | No | EVA | |
| rs3389364737 | 58 | Q>P | No | EVA | |
| rs3389353401 | 64 | K>M | No | EVA | |
| rs3389352676 | 72 | K>* | No | EVA | |
| rs3389353357 | 74 | Q>* | No | EVA | |
| rs46442581 | 74 | Q>R | No | EVA | |
| rs259355252 | 94 | G>D | No | EVA | |
| rs241266554 | 100 | R>* | No | EVA | |
| rs3389369312 | 113 | G>S | No | EVA | |
| rs3389364716 | 125 | L>S | No | EVA | |
| rs3389360377 | 125 | L>V | No | EVA | |
| rs3389360322 | 133 | N>K | No | EVA | |
| rs6375548 | 140 | L>P | No | EVA | |
| rs48612388 | 192 | T>K | No | EVA | |
| rs230058812 | 203 | M>I | No | EVA | |
| rs212991780 | 213 | P>A | No | EVA | |
| rs3389352719 | 225 | E>K | No | EVA | |
| rs3389336771 | 238 | S>C | No | EVA | |
| rs237429122 | 270 | D>N | No | EVA | |
| rs216461030 | 279 | R>Q | No | EVA | |
| rs253434863 | 329 | S>G | No | EVA | |
| rs50153586 | 329 | S>N | No | EVA | |
| rs234422611 | 332 | G>C | No | EVA | |
| rs3389336803 | 336 | Y>C | No | EVA | |
| rs3389360326 | 337 | V>M | No | EVA | |
| rs3389307412 | 354 | L>V | No | EVA | |
| rs46882047 | 362 | C>R | No | EVA | |
| rs257244343 | 383 | R>C | No | EVA | |
| rs3389348678 | 386 | M>I | No | EVA | |
| rs3389364729 | 414 | L>* | No | EVA | |
| rs52049209 | 420 | R>Q | No | EVA | |
| rs3389345142 | 424 | S>F | No | EVA |
No associated diseases with Q32MW3
2 regional properties for Q32MW3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Hotdog acyl-CoA thioesterase (ACOT)-type domain | 85 - 209 | IPR033120-1 |
| domain | Hotdog acyl-CoA thioesterase (ACOT)-type domain | 289 - 401 | IPR033120-2 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| acyl-CoA hydrolase activity | Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate. |
| carboxylic ester hydrolase activity | Catalysis of the hydrolysis of a carboxylic ester bond. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| acyl-CoA metabolic process | The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SWX2 | ACOT9 | Acyl-coenzyme A thioesterase 9, mitochondrial | Bos taurus (Bovine) | PR |
| Q8WYK0 | ACOT12 | Acetyl-coenzyme A thioesterase | Homo sapiens (Human) | PR |
| O00154 | ACOT7 | Cytosolic acyl coenzyme A thioester hydrolase | Homo sapiens (Human) | PR |
| Q9Y305 | ACOT9 | Acyl-coenzyme A thioesterase 9, mitochondrial | Homo sapiens (Human) | PR |
| Q9DBK0 | Acot12 | Acetyl-coenzyme A thioesterase | Mus musculus (Mouse) | PR |
| Q91V12 | Acot7 | Cytosolic acyl coenzyme A thioester hydrolase | Mus musculus (Mouse) | PR |
| Q8VHQ9 | Acot11 | Acyl-coenzyme A thioesterase 11 | Mus musculus (Mouse) | PR |
| Q9R0X4 | Acot9 | Acyl-coenzyme A thioesterase 9, mitochondrial | Mus musculus (Mouse) | PR |
| Q64559 | Acot7 | Cytosolic acyl coenzyme A thioester hydrolase | Rattus norvegicus (Rat) | PR |
| Q99NB7 | Acot12 | Acetyl-coenzyme A thioesterase | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKRAAMRLWT | LNKGLLTHGR | GLSQGSQYKI | SEPLHIHQVQ | VKLREIVGIS | TVWRDHVQAM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EERKLLHSFL | PKSQKVLPPR | KIRDSYIEVL | LPLGTDPELR | DKYVTVQNTV | RFGRILEDLD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SLGVLVCYMH | NHNHSTNMSL | LSIVTVLVDK | IDMCKHSLSP | EQDIKFTGHV | SWVGNTTMEV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KMKMFQLHDD | ETYWPVLDAT | FVMVAQDSEN | KRPAFVNPLI | PENKEEEELF | TQGELNKSRR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IAFSTSSLLK | VAPSSEERNI | IHELFLSTLD | PKTISFQSRI | LPPKAVWMED | TKLKSLDICH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PQERNVFNRI | FGGFLMRKAY | ELAWATACSF | GGSRPYVVTV | DDIMFQKPVE | VGSLLFLSSQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VCFTQGNYIQ | VRVHSEVFSL | DSREHMTTNV | FHFTFMSEKE | VPLIFPKTYG | ESMLYLDGQR |
| 430 | |||||
| HFKSMSTPVT | LKKDYPVEP |