AiPD: Autoinhibited Protein Database

Gene name	Acot12 (Cach, Cach1)
Protein name	Acetyl-coenzyme A thioesterase
Names	Acyl-CoA thioester hydrolase 12, Acyl-coenzyme A thioesterase 12, Acyl-CoA thioesterase 12, Cytoplasmic acetyl-CoA hydrolase 1, CACH-1, mCACH-1
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:74156
EC number	3.1.2.1: Thiolester hydrolases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

98-215 (Predicted disordered autoinhibitory region) PR

98-215 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9DBK0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389279732	6	A>E	No	EVA
rs3389252999	84	T>I	No	EVA
rs3389293381	91	K>E	No	EVA
rs3389223397	92	V>I	No	EVA
rs3389292051	113	V>I	No	EVA
rs220063174	165	F>V	No	EVA
rs3389292101	170	C>S	No	EVA
rs3389298414	216	I>M	No	EVA
rs3389312053	231	V>A	No	EVA
rs3389312017	236	F>I	No	EVA
rs3389268787	238	G>E	No	EVA
rs3389268784	265	R>L	No	EVA
rs29242977	313	R>H	No	EVA
rs3389292082	314	R>C	No	EVA
rs224071981	351	S>F	No	EVA
rs3389279819	359	A>V	No	EVA
rs3389312009	390	S>P	No	EVA
rs3389261464	394	E>V	No	EVA
rs3389297396	395	K>R	No	EVA
rs3389302539	396	L>P	No	EVA
rs3404601431	399	S>C	No	EVA
rs3404404621	399	S>R	No	EVA
rs3389298451	400	P>S	No	EVA
rs3389298451	400	P>T	No	EVA
rs3389293442	442	S>L	No	EVA
rs3389312095	448	K>I	No	EVA
rs3389298386	458	R>G	No	EVA
rs3404053775	462	L>H	No	EVA
rs3404501845	463	K>T	No	EVA
rs217602241	465	N>T	No	EVA
rs254330267	465	N>Y	No	EVA
rs3389297339	488	R>G	No	EVA
rs3389293235	521	Y>H	No	EVA

Type	Name	Position	InterPro Accession
domain	START domain	349 - 550	IPR002913
domain	Thioesterase domain	29 - 95	IPR006683-1
domain	Thioesterase domain	198 - 271	IPR006683-2
domain	Hotdog acyl-CoA thioesterase (ACOT)-type domain	6 - 118	IPR033120-1
domain	Hotdog acyl-CoA thioesterase (ACOT)-type domain	180 - 295	IPR033120-2

		Description
EC Number	3.1.2.1	Thiolester hydrolases
Subcellular Localization	Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
intercellular bridge	A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

Name	Definition
acetyl-CoA hydrolase activity	Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+).
acyl-CoA hydrolase activity	Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
carboxylic ester hydrolase activity	Catalysis of the hydrolysis of a carboxylic ester bond.
identical protein binding	Binding to an identical protein or proteins.
long-chain fatty acyl-CoA binding	Binding to a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.

Name	Definition
acetyl-CoA metabolic process	The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
acyl-CoA metabolic process	The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.
fatty acid metabolic process	The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3SWX2	ACOT9	Acyl-coenzyme A thioesterase 9, mitochondrial	Bos taurus (Bovine)	PR
O00154	ACOT7	Cytosolic acyl coenzyme A thioester hydrolase	Homo sapiens (Human)	PR
Q9Y305	ACOT9	Acyl-coenzyme A thioesterase 9, mitochondrial	Homo sapiens (Human)	PR
Q8WYK0	ACOT12	Acetyl-coenzyme A thioesterase	Homo sapiens (Human)	PR
Q9R0X4	Acot9	Acyl-coenzyme A thioesterase 9, mitochondrial	Mus musculus (Mouse)	PR
Q32MW3	Acot10	Acyl-coenzyme A thioesterase 10, mitochondrial	Mus musculus (Mouse)	PR
Q8VHQ9	Acot11	Acyl-coenzyme A thioesterase 11	Mus musculus (Mouse)	PR
Q91V12	Acot7	Cytosolic acyl coenzyme A thioester hydrolase	Mus musculus (Mouse)	PR
Q64559	Acot7	Cytosolic acyl coenzyme A thioester hydrolase	Rattus norvegicus (Rat)	PR
Q99NB7	Acot12	Acetyl-coenzyme A thioesterase	Rattus norvegicus (Rat)	PR