Q9R0X4
Gene name |
Acot9 (Acate2) |
Protein name |
Acyl-coenzyme A thioesterase 9, mitochondrial |
Names |
Acyl-CoA thioesterase 9, Acyl coenzyme A thioester hydrolase 2, MTE-2, Acyl-CoA thioester hydrolase 9, Mitochondrial 48 kDa acyl-CoA thioester hydrolase 1, Mt-ACT48.1, Protein U8, p48 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:56360 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9R0X4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9R0X4-F1 | Predicted | AlphaFoldDB |
25 variants for Q9R0X4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3411594325 | 71 | P>S | No | EVA | |
| rs3412312923 | 78 | P>S | No | EVA | |
| rs3389574061 | 87 | I>N | No | EVA | |
| rs3412603593 | 175 | N>K | No | EVA | |
| rs3389592961 | 184 | M>I | No | EVA | |
| rs234121038 | 220 | I>V | No | EVA | |
| rs3389577375 | 232 | Q>E | No | EVA | |
| rs3389588224 | 258 | R>M | No | EVA | |
| rs3389574105 | 269 | L>M | No | EVA | |
| rs260219360 | 306 | V>I | No | EVA | |
| rs3409684609 | 313 | G>A | No | EVA | |
| rs3411092800 | 316 | M>I | No | EVA | |
| rs3412348135 | 319 | A>P | No | EVA | |
| rs3389592885 | 332 | G>S | No | EVA | |
| rs3411092846 | 340 | V>G | No | EVA | |
| rs3389581771 | 347 | K>* | No | EVA | |
| rs3389580570 | 355 | L>P | No | EVA | |
| rs3412431762 | 365 | Q>L | No | EVA | |
| rs3389574604 | 381 | D>E | No | EVA | |
| rs3411985101 | 381 | D>N | No | EVA | |
| rs3389588187 | 402 | P>S | No | EVA | |
| rs3412792903 | 404 | I>V | No | EVA | |
| rs3411594447 | 412 | S>F | No | EVA | |
| rs3412792927 | 423 | K>SMPFAP* | No | EVA | |
| rs212109067 | 427 | T>I | No | EVA |
No associated diseases with Q9R0X4
2 regional properties for Q9R0X4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Hotdog acyl-CoA thioesterase (ACOT)-type domain | 85 - 209 | IPR033120-1 |
| domain | Hotdog acyl-CoA thioesterase (ACOT)-type domain | 289 - 401 | IPR033120-2 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| acetyl-CoA hydrolase activity | Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+). |
| acyl-CoA hydrolase activity | Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate. |
| carboxylic ester hydrolase activity | Catalysis of the hydrolysis of a carboxylic ester bond. |
| palmitoyl-CoA hydrolase activity | Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| acyl-CoA metabolic process | The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. |
| long-chain fatty acid metabolic process | The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. |
| short-chain fatty acid metabolic process | The chemical reactions and pathways involving fatty acids with a chain length of less than C6. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SWX2 | ACOT9 | Acyl-coenzyme A thioesterase 9, mitochondrial | Bos taurus (Bovine) | PR |
| Q8WYK0 | ACOT12 | Acetyl-coenzyme A thioesterase | Homo sapiens (Human) | PR |
| O00154 | ACOT7 | Cytosolic acyl coenzyme A thioester hydrolase | Homo sapiens (Human) | PR |
| Q9Y305 | ACOT9 | Acyl-coenzyme A thioesterase 9, mitochondrial | Homo sapiens (Human) | PR |
| Q9DBK0 | Acot12 | Acetyl-coenzyme A thioesterase | Mus musculus (Mouse) | PR |
| Q91V12 | Acot7 | Cytosolic acyl coenzyme A thioester hydrolase | Mus musculus (Mouse) | PR |
| Q8VHQ9 | Acot11 | Acyl-coenzyme A thioesterase 11 | Mus musculus (Mouse) | PR |
| Q32MW3 | Acot10 | Acyl-coenzyme A thioesterase 10, mitochondrial | Mus musculus (Mouse) | PR |
| Q64559 | Acot7 | Cytosolic acyl coenzyme A thioester hydrolase | Rattus norvegicus (Rat) | PR |
| Q99NB7 | Acot12 | Acetyl-coenzyme A thioesterase | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKRAAIRLWT | LNKGLLTHGR | GLSQGSQYKI | SEPLHIHQVR | DKLREIVGVS | TVWRDHVKAM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EERKLLHSFL | PKSQKVLPPR | KMRDSYIEVL | LPLGTDPELR | DKYVTVQNTV | RFGRILEDLD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SLGVLVCYMH | NHNHSTKMSP | LSIVTVLVDK | IDMCKHSLSP | EQDIKFTGHV | SWVGNTSMEV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KMKMFQLHND | EKYWPVLDAT | FVMVARDSEN | KGPAFVNPLI | PENKEEEELF | KQGELNKSRR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IAFSTSSLLK | VAPSSEERNI | IHELFLTTLD | PKTISFQSRI | LPPKAVWMED | TKLKSLDICH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PQERNVFNRI | FGGFLMRKAY | ELAWATACSF | GGSRPYVVTV | DDIMFQKPVE | VGSLLFLSSQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VCFTQDNYIQ | VRVHSEVSSL | DSREHMTTNV | FHFTFMSEKE | VPLIFPKTYG | ESMLYLDGQR |
| 430 | |||||
| HFKSMSTPVT | LKKDYPVEP |