Q9Y2T4
PR
Gene name |
PPP2R2C |
Protein name |
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform |
Names |
IMYPNO1, PP2A subunit B isoform B55-gamma, PP2A subunit B isoform PR55-gamma, PP2A subunit B isoform R2-gamma, PP2A subunit B isoform gamma |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:5522 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9Y2T4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Y2T4-F1 | Predicted | AlphaFoldDB |
221 variants for Q9Y2T4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs747864353 | 1 | M>? | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs768280067 CA2840346 |
2 | G>A | No |
ClinGen ExAC gnomAD |
|
|
rs1194206870 CA356275431 |
7 | T>A | No |
ClinGen gnomAD |
|
|
rs1489153323 CA356275428 |
7 | T>K | No |
ClinGen gnomAD |
|
|
CA356275424 rs1289255132 |
8 | R>W | No |
ClinGen gnomAD |
|
|
rs949371849 CA92311367 |
15 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
CA356275358 rs1453652431 |
17 | D>E | No |
ClinGen TOPMed |
|
| TCGA novel | 17 | D>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA356275354 rs1401400042 |
18 | H>Y | No |
ClinGen gnomAD |
|
| TCGA novel | 22 | T>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA356187166 rs1263044518 |
26 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1577129682 CA356187152 |
28 | S>P | No |
ClinGen Ensembl |
|
|
rs1009200231 CA91862583 |
29 | T>A | No |
ClinGen Ensembl |
|
|
CA356187142 rs1272579006 |
30 | V>I | No |
ClinGen TOPMed gnomAD |
|
|
rs751114949 CA2840214 |
33 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA91862570 rs1031902855 |
34 | H>D | No |
ClinGen Ensembl |
|
|
CA2840212 rs757810061 |
35 | T>M | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 36 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2840209 rs761226047 |
37 | E>D | No |
ClinGen ExAC gnomAD |
|
|
rs1389426870 CA356187078 |
40 | A>T | No |
ClinGen gnomAD |
|
|
CA356187054 rs1386974387 |
43 | D>E | No |
ClinGen TOPMed |
|
|
rs1169073410 CA356187037 |
46 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
CA91862552 rs904676187 |
47 | R>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs1577129554 CA356187025 |
48 | V>G | No |
ClinGen Ensembl |
|
|
CA356187028 rs1373942538 |
48 | V>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1032321120 CA91862541 |
49 | V>I | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 50 | I>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1334918091 CA356187016 |
50 | I>V | No |
ClinGen gnomAD |
|
|
CA356186992 rs1214385056 |
53 | R>Q | No |
ClinGen gnomAD |
|
|
CA2840203 rs762909236 |
53 | R>W | No |
ClinGen ExAC gnomAD |
|
|
CA2840202 rs775771834 |
54 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1265972688 CA356186980 |
55 | P>Q | No |
ClinGen TOPMed |
|
|
CA356186951 rs201343301 |
57 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA91861069 rs375793522 |
57 | S>T | No |
ClinGen Ensembl |
|
|
CA2840171 rs781641771 |
58 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
CA356186930 rs202026671 |
60 | A>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1257912436 CA356186933 |
60 | A>S | No |
ClinGen gnomAD |
|
|
CA2840170 rs202026671 |
60 | A>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1283010592 CA356186893 |
65 | G>V | No |
ClinGen gnomAD |
|
|
rs200176027 CA91861062 |
66 | E>K | No |
ClinGen 1000Genomes |
|
|
rs200481224 CA356186872 |
68 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs752918306 CA2840166 |
68 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1355262542 CA356186870 |
69 | V>M | No |
ClinGen gnomAD |
|
|
rs1343939204 CA356186766 |
77 | E>K | No |
ClinGen gnomAD |
|
|
rs760729044 CA2840161 |
78 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2840158 rs761614602 |
85 | S>T | No |
ClinGen ExAC gnomAD |
|
|
CA356186603 rs1577126580 |
89 | E>V | No |
ClinGen Ensembl |
|
|
rs1305208352 CA356186596 |
90 | E>K | No |
ClinGen gnomAD |
|
|
CA2840156 rs768337204 |
103 | A>P | No |
ClinGen ExAC gnomAD |
|
|
CA2840154 rs779671991 |
104 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2840153 rs769193125 |
105 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2840121 rs762760790 |
118 | W>S | No |
ClinGen ExAC gnomAD |
|
|
CA2840120 rs775168990 |
121 | T>S | No |
ClinGen ExAC gnomAD |
|
|
CA2840118 rs759067979 |
122 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs1478956407 CA356186052 |
122 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA91859342 rs964976059 |
123 | R>* | No |
ClinGen Ensembl |
|
|
rs150954241 CA91859338 |
124 | D>N | No |
ClinGen Ensembl |
|
|
CA2840116 rs190838630 |
126 | R>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA91859336 rs896915961 |
126 | R>S | No |
ClinGen TOPMed gnomAD |
|
|
rs866322387 CA91859319 |
129 | G>R | No |
ClinGen Ensembl |
|
|
rs1031797235 CA91859299 |
136 | E>Q | No |
ClinGen Ensembl |
|
|
rs1341987148 CA356185877 |
137 | G>R | No |
ClinGen TOPMed |
|
| TCGA novel | 137 | G>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA356185820 rs1298604554 |
141 | D>E | No |
ClinGen gnomAD |
|
|
rs1372860491 CA356185822 |
141 | D>G | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA2840109 rs139419142 |
142 | L>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2840110 rs139419142 |
142 | L>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2840107 rs763126722 |
144 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2840105 rs764052676 |
146 | T>M | No |
ClinGen ExAC gnomAD |
|
|
rs752487442 CA356185782 |
149 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
CA2840103 rs752487442 |
149 | Q>K | No |
ClinGen ExAC gnomAD |
|
|
CA356185779 rs1404338076 |
149 | Q>R | No |
ClinGen gnomAD |
|
|
rs1036394073 CA91856459 |
156 | M>V | No |
ClinGen TOPMed |
|
| TCGA novel | 161 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA356185434 rs1317972600 |
161 | E>G | No |
ClinGen TOPMed |
|
|
CA356185409 rs1385100274 |
163 | S>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1459598988 CA356185345 |
170 | N>S | No |
ClinGen gnomAD |
|
|
rs1393273164 CA356185317 |
173 | T>P | No |
ClinGen gnomAD |
|
|
rs1165114993 CA356185308 |
174 | Y>N | No |
ClinGen gnomAD |
|
|
rs373814468 CA2840075 |
181 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA2840073 rs150561015 |
185 | C>Y | No |
ClinGen ESP ExAC |
|
|
rs1184521250 CA356185149 |
189 | M>V | No |
ClinGen TOPMed |
|
|
rs369585524 CA2840070 |
191 | A>V | No |
ClinGen ESP ExAC gnomAD |
|
| TCGA novel | 192 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1214496946 CA356185104 |
193 | D>A | No |
ClinGen gnomAD |
|
|
CA356185102 rs1214496946 |
193 | D>G | No |
ClinGen gnomAD |
|
|
CA356185093 rs1577119722 |
194 | L>P | No |
ClinGen Ensembl |
|
|
rs747980900 CA2840068 |
195 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA2840067 rs778929388 |
195 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1577119709 CA356185068 |
197 | N>T | No |
ClinGen Ensembl |
|
|
rs1577119699 CA356185039 |
200 | H>P | No |
ClinGen Ensembl |
|
|
CA356185024 rs1577119690 |
202 | A>P | No |
ClinGen Ensembl |
|
|
rs1577119678 CA356185005 |
204 | T>P | No |
ClinGen Ensembl |
|
|
CA356185001 rs1162516236 |
204 | T>S | No |
ClinGen TOPMed |
|
|
rs371827360 CA91827113 |
211 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP NCI-TCGA gnomAD |
|
rs1247259830 CA356181734 |
214 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
rs1347846860 CA356181730 |
215 | P>L | No |
ClinGen gnomAD |
|
|
CA356181727 rs1239262134 |
216 | A>T | No |
ClinGen gnomAD |
|
|
CA2840040 rs765650812 |
217 | N>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA356181708 rs1354612897 |
218 | M>I | No |
ClinGen gnomAD |
|
|
rs1375368070 CA356181691 |
220 | D>E | No |
ClinGen gnomAD |
|
|
rs1456538721 CA356181684 |
221 | L>R | No |
ClinGen TOPMed |
|
|
CA91827100 rs916280657 |
222 | T>M | No |
ClinGen gnomAD |
|
|
rs1577090508 CA356181628 |
230 | F>S | No |
ClinGen Ensembl |
|
|
CA2840035 rs773263494 |
231 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1185518267 CA356181607 |
233 | H>P | No |
ClinGen TOPMed gnomAD |
|
|
rs1474880466 CA356181604 |
233 | H>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs1185518267 CA356181606 |
233 | H>R | No |
ClinGen TOPMed gnomAD |
|
|
CA2840032 rs774545521 |
236 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA356181583 rs774545521 |
236 | N>T | No |
ClinGen ExAC gnomAD |
|
|
CA2840031 rs768473282 |
237 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA2840029 rs775581608 |
239 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA356181518 rs1560465955 |
245 | G>D | No |
ClinGen Ensembl |
|
|
CA356181510 rs1450767373 |
246 | S>F | No |
ClinGen gnomAD |
|
|
rs756994097 CA2840025 |
248 | R>Q | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 251 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs757919406 CA2840022 |
253 | R>W | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 261 | H>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA356181406 rs1460745968 |
262 | S>C | No |
ClinGen gnomAD |
|
| TCGA novel | 262 | S>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 264 | L>= | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2840018 rs750844235 |
264 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA356181395 rs750844235 |
264 | L>I | No |
ClinGen ExAC gnomAD |
|
|
CA356180285 rs1577072836 |
270 | D>A | No |
ClinGen Ensembl |
|
|
CA356180264 rs1560449531 |
272 | S>G | No |
ClinGen Ensembl |
|
|
CA356180249 rs1370669801 |
272 | S>R | No |
ClinGen TOPMed |
|
|
rs1401064445 CA356180225 |
274 | R>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA2839990 rs776449314 |
274 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs760422388 CA2839988 |
278 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1426654793 CA356180150 |
279 | E>D | No |
ClinGen gnomAD |
|
|
CA2839985 rs747639231 |
284 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA356180053 rs1389741773 |
286 | D>N | No |
ClinGen TOPMed |
|
|
rs781570469 CA2839981 |
287 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA356179934 rs1222177679 |
292 | S>N | No |
ClinGen gnomAD |
|
|
CA91811846 rs964415543 |
293 | G>S | No |
ClinGen TOPMed |
|
|
rs1268217098 CA356179891 |
294 | R>C | No |
ClinGen gnomAD |
|
|
rs868460193 CA91811839 |
294 | R>L | No |
ClinGen Ensembl |
|
|
rs1312118358 CA356179838 |
296 | M>R | No |
ClinGen gnomAD |
|
|
CA2839978 rs368801587 |
296 | M>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA356179802 rs1360583500 |
298 | T>A | No |
ClinGen gnomAD |
|
| TCGA novel | 299 | R>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs374362764 CA2839976 |
302 | L>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA gnomAD |
| TCGA novel | 310 | N>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA356179457 rs1201663134 |
313 | A>T | No |
ClinGen TOPMed |
|
|
CA356179444 rs1183543693 |
314 | R>G | No |
ClinGen gnomAD |
|
|
CA91811745 rs531829023 |
314 | R>K | No |
ClinGen 1000Genomes TOPMed |
|
|
rs753771610 CA2839973 |
316 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA356179406 rs1473897058 |
316 | I>V | No |
ClinGen gnomAD |
|
| TCGA novel | 317 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs762501712 CA2839945 |
323 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs763692349 CA2839946 |
323 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA356178110 rs1190542476 |
324 | Y>S | No |
ClinGen gnomAD |
|
|
CA2839944 rs374272092 |
326 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs773880296 CA2839941 |
334 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA2839939 rs748566105 |
336 | D>H | No |
ClinGen ExAC gnomAD |
|
|
CA2839937 rs755209779 |
340 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs749379375 CA2839936 |
341 | K>T | No |
ClinGen ExAC gnomAD |
|
|
CA356177831 rs1168119647 |
344 | C>S | No |
ClinGen TOPMed |
|
|
rs779928185 CA2839935 |
345 | A>S | No |
ClinGen ExAC gnomAD |
|
|
CA2839933 rs267600204 |
348 | G>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA356177743 rs757014009 |
349 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA356177730 rs1429541816 |
350 | D>G | No |
ClinGen gnomAD |
|
|
CA356177737 rs1453968502 |
350 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA2839905 rs762339661 |
352 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA91801298 rs948636545 |
353 | I>V | No |
ClinGen TOPMed |
|
|
rs768851640 CA2839903 |
357 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA2839902 rs763404513 |
363 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA2839901 rs775542255 |
365 | F>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs770049137 CA2839900 |
366 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA2839899 rs367696094 |
367 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA gnomAD |
|
rs1204594682 CA356176021 |
367 | R>W | No |
ClinGen TOPMed |
|
|
rs1577063114 CA356175994 |
369 | T>P | No |
ClinGen Ensembl |
|
|
rs781182513 CA2839898 |
371 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA356175956 rs1340045766 |
371 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA356175925 rs1158595049 |
373 | V>M | No |
ClinGen gnomAD |
|
|
rs1577063066 CA356175912 |
374 | T>P | No |
ClinGen Ensembl |
|
|
CA356175853 rs1242711583 |
378 | S>* | No |
ClinGen TOPMed |
|
|
rs1242711583 CA356175850 |
378 | S>L | No |
ClinGen TOPMed |
|
|
rs752589937 CA2839893 |
379 | R>K | No |
ClinGen ExAC gnomAD |
|
|
rs754747800 CA2839891 |
380 | E>G | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs753541104 CA2839890 |
381 | S>G | No |
ClinGen ExAC gnomAD |
|
|
CA91801136 rs1048743697 |
383 | K>E | No |
ClinGen Ensembl |
|
|
rs765926966 CA2839889 |
384 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs1444984786 CA356175769 |
384 | P>S | No |
ClinGen gnomAD |
|
|
CA356175763 rs1330379905 |
385 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA2839888 rs760251644 |
385 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA356175758 rs1270601018 |
386 | A>P | No |
ClinGen gnomAD |
|
|
rs1175331044 CA356175727 |
391 | R>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA2839886 rs750077410 |
391 | R>W | Variant assessed as Somatic; 9.26e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA2839885 rs763204097 |
392 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA356175722 rs1403427226 |
392 | R>H | No |
ClinGen TOPMed |
|
|
rs1363348655 CA356175710 |
394 | C>Y | No |
ClinGen gnomAD |
|
|
CA2839882 rs375066274 |
395 | V>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2839881 rs375066274 |
395 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA356175700 rs1162714277 |
396 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
CA2839880 rs770960380 |
397 | G>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA356175680 rs1164835896 |
399 | R>C | No |
ClinGen gnomAD |
|
|
CA2839878 rs200809882 |
399 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs747148764 CA91801028 |
400 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs778779009 CA2839875 |
400 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs754837498 CA2839874 |
401 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs748903409 CA2839873 |
401 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754837498 CA356175674 |
401 | R>S | No |
ClinGen ExAC gnomAD |
|
|
rs1214417537 CA356175661 |
403 | D>H | No |
ClinGen TOPMed |
|
|
CA356175653 rs1467691614 |
404 | I>V | No |
ClinGen gnomAD |
|
|
CA356175584 rs1270935998 |
413 | K>R | No |
ClinGen TOPMed |
|
|
CA2839869 rs371740090 |
418 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA91800940 rs897978474 |
422 | P>S | No |
ClinGen TOPMed |
|
| TCGA novel | 425 | N>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs3796403 CA356175459 |
429 | I>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs545674626 CA91800915 |
429 | I>T | No |
ClinGen 1000Genomes |
|
|
rs1427606304 CA356175456 |
430 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
rs759923972 CA2839865 |
431 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA91800886 rs969324820 |
437 | I>V | No |
ClinGen Ensembl |
|
|
rs776801658 CA2839864 |
439 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
CA91800881 rs1022279531 |
442 | V>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1392708055 CA356175372 |
442 | V>I | No |
ClinGen gnomAD |
|
|
rs766669913 CA2839863 |
443 | N>D | No |
ClinGen ExAC gnomAD |
|
|
CA2839861 rs760655172 |
446 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1350113609 CA356175331 |
447 | H>Q | No |
ClinGen TOPMed |
|
|
rs1450253169 CA356175336 |
447 | H>Y | No |
ClinGen gnomAD |
No associated diseases with Q9Y2T4
8 regional properties for Q9Y2T4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 13 - 52 | IPR001680-1 |
| repeat | WD40 repeat | 79 - 119 | IPR001680-2 |
| repeat | WD40 repeat | 161 - 200 | IPR001680-3 |
| repeat | WD40 repeat | 211 - 251 | IPR001680-4 |
| repeat | WD40 repeat | 270 - 308 | IPR001680-5 |
| repeat | WD40 repeat | 402 - 439 | IPR001680-6 |
| conserved_site | Protein phosphatase 2A regulatory subunit PR55, conserved site | 79 - 93 | IPR018067-1 |
| conserved_site | Protein phosphatase 2A regulatory subunit PR55, conserved site | 170 - 184 | IPR018067-2 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| protein phosphatase type 2A complex | A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein phosphatase regulator activity | Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5E9Q7 | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Bos taurus (Bovine) | PR |
| Q5ZIY5 | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform | Gallus gallus (Chicken) | PR |
| Q00005 | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Homo sapiens (Human) | PR |
| Q66LE6 | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform | Homo sapiens (Human) | PR |
| Q6P1F6 | Ppp2r2a | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform | Mus musculus (Mouse) | PR |
| Q6ZWR4 | Ppp2r2b | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Mus musculus (Mouse) | PR |
| Q8BG02 | Ppp2r2c | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform | Mus musculus (Mouse) | PR |
| P54614 | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Sus scrofa (Pig) | PR |
| P36877 | Ppp2r2b | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Rattus norvegicus (Rat) | PR |
| P97888 | Ppp2r2c | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform | Rattus norvegicus (Rat) | PR |
| Q0E2P1 | Os02g0224200 | Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Oryza sativa subsp japonica (Rice) | PR |
| Q38821 | PP2AB1 | Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0D2F4 | ppp2r2b | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6DIY3 | ppp2r2d | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6NY64 | ppp2r2d | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGEDTDTRKI | NHSFLRDHSY | VTEADIISTV | EFNHTGELLA | TGDKGGRVVI | FQREPESKNA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PHSQGEYDVY | STFQSHEPEF | DYLKSLEIEE | KINKIKWLPQ | QNAAHSLLST | NDKTIKLWKI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TERDKRPEGY | NLKDEEGKLK | DLSTVTSLQV | PVLKPMDLMV | EVSPRRIFAN | GHTYHINSIS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VNSDCETYMS | ADDLRINLWH | LAITDRSFNI | VDIKPANMED | LTEVITASEF | HPHHCNLFVY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SSSKGSLRLC | DMRAAALCDK | HSKLFEEPED | PSNRSFFSEI | ISSVSDVKFS | HSGRYMLTRD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YLTVKVWDLN | MEARPIETYQ | VHDYLRSKLC | SLYENDCIFD | KFECAWNGSD | SVIMTGAYNN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FFRMFDRNTK | RDVTLEASRE | SSKPRAVLKP | RRVCVGGKRR | RDDISVDSLD | FTKKILHTAW |
| 430 | 440 | ||||
| HPAENIIAIA | ATNNLYIFQD | KVNSDMH |