Q6P1F6
PR
Gene name |
Ppp2r2a |
Protein name |
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform |
Names |
PP2A subunit B isoform B55-alpha, PP2A subunit B isoform PR55-alpha, PP2A subunit B isoform R2-alpha, PP2A subunit B isoform alpha |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:71978 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6P1F6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6P1F6-F1 | Predicted | AlphaFoldDB |
17 variants for Q6P1F6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389341996 | 15 | S>F | No | EVA | |
| rs3389335385 | 42 | L>F | No | EVA | |
| rs3389341958 | 49 | G>D | No | EVA | |
| rs3389302977 | 82 | P>S | No | EVA | |
| rs3389351114 | 131 | P>T | No | EVA | |
| rs3389328700 | 132 | E>D | No | EVA | |
| rs3405216113 | 176 | H>P | No | EVA | |
| rs3389336969 | 210 | R>M | No | EVA | |
| rs3389335393 | 288 | I>F | No | EVA | |
| rs3389340611 | 300 | M>K | No | EVA | |
| rs3389334172 | 325 | V>I | No | EVA | |
| rs3389262082 | 351 | N>S | No | EVA | |
| rs3389262062 | 367 | R>K | No | EVA | |
| rs3389262113 | 392 | L>M | No | EVA | |
| rs3389322344 | 400 | S>N | No | EVA | |
| rs3389262053 | 409 | S>C | No | EVA | |
| rs3389262090 | 428 | E>D | No | EVA |
No associated diseases with Q6P1F6
9 regional properties for Q6P1F6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 21 - 56 | IPR001680-1 |
| repeat | WD40 repeat | 83 - 123 | IPR001680-2 |
| repeat | WD40 repeat | 165 - 204 | IPR001680-3 |
| repeat | WD40 repeat | 215 - 255 | IPR001680-4 |
| repeat | WD40 repeat | 274 - 312 | IPR001680-5 |
| repeat | WD40 repeat | 339 - 370 | IPR001680-6 |
| repeat | WD40 repeat | 406 - 443 | IPR001680-7 |
| conserved_site | Protein phosphatase 2A regulatory subunit PR55, conserved site | 83 - 97 | IPR018067-1 |
| conserved_site | Protein phosphatase 2A regulatory subunit PR55, conserved site | 174 - 188 | IPR018067-2 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| protein phosphatase type 2A complex | A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein phosphatase 2A binding | Binding to protein phosphatase 2A. |
| protein phosphatase regulator activity | Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. |
| protein-containing complex binding | Binding to a macromolecular complex. |
| tau protein binding | Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein dephosphorylation | The process of removing one or more phosphoric residues from a protein. |
| response to morphine | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5E9Q7 | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Bos taurus (Bovine) | PR |
| Q5ZIY5 | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform | Gallus gallus (Chicken) | PR |
| Q00005 | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Homo sapiens (Human) | PR |
| Q9Y2T4 | PPP2R2C | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform | Homo sapiens (Human) | PR |
| Q66LE6 | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform | Homo sapiens (Human) | PR |
| Q8BG02 | Ppp2r2c | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform | Mus musculus (Mouse) | PR |
| Q6ZWR4 | Ppp2r2b | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Mus musculus (Mouse) | PR |
| P54614 | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Sus scrofa (Pig) | PR |
| P97888 | Ppp2r2c | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform | Rattus norvegicus (Rat) | PR |
| P36877 | Ppp2r2b | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Rattus norvegicus (Rat) | PR |
| Q0E2P1 | Os02g0224200 | Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Oryza sativa subsp japonica (Rice) | PR |
| Q38821 | PP2AB1 | Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0D2F4 | ppp2r2b | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6DIY3 | ppp2r2d | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6NY64 | ppp2r2d | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGAGGGNDI | QWCFSQVKGA | VDDDVAEADI | ISTVEFNHSG | ELLATGDKGG | RVVIFQQEQE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NKIQSHSRGE | YNVYSTFQSH | EPEFDYLKSL | EIEEKINKIR | WLPQKNAAQF | LLSTNDKTIK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LWKISERDKR | PEGYNLKEED | GRYRDPTTVT | TLRVPVFRPM | DLMVEASPRR | IFANAHTYHI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NSISINSDYE | TYLSADDLRI | NLWHLEITDR | SFNIVDIKPA | NMEELTEVIT | AAEFHPNSCN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TFVYSSSKGT | IRLCDMRASA | LCDRHSKLFE | EPEDPSNRSF | FSEIISSISD | VKFSHSGRYM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MTRDYLSVKI | WDLNMENRPV | ETYQVHEYLR | SKLCSLYEND | CIFDKFECCW | NGSDSVVMTG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SYNNFFRMFD | RNTKRDITLE | ASRENNKPRT | VLKPRKVCAS | GKRKKDEISV | DSLDFNKKIL |
| 430 | 440 | ||||
| HTAWHPKENI | IAVATTNNLY | IFQDKVN |