P36877
PR
Gene name |
Ppp2r2b |
Protein name |
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform |
Names |
PP2A subunit B isoform B55-beta, PP2A subunit B isoform BRB, PP2A subunit B isoform PR55-beta, PP2A subunit B isoform R2-beta, PP2A subunit B isoform beta |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:60660 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P36877
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P36877-F1 | Predicted | AlphaFoldDB |
No variants for P36877
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P36877 | |||||
No associated diseases with P36877
8 regional properties for P36877
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 13 - 52 | IPR001680-1 |
| repeat | WD40 repeat | 79 - 119 | IPR001680-2 |
| repeat | WD40 repeat | 161 - 200 | IPR001680-3 |
| repeat | WD40 repeat | 211 - 251 | IPR001680-4 |
| repeat | WD40 repeat | 270 - 308 | IPR001680-5 |
| repeat | WD40 repeat | 402 - 439 | IPR001680-6 |
| conserved_site | Protein phosphatase 2A regulatory subunit PR55, conserved site | 79 - 93 | IPR018067-1 |
| conserved_site | Protein phosphatase 2A regulatory subunit PR55, conserved site | 170 - 184 | IPR018067-2 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| protein phosphatase type 2A complex | A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein phosphatase regulator activity | Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. |
| protein-containing complex binding | Binding to a macromolecular complex. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| mitochondrial fission | The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. |
| mitochondrial fragmentation involved in apoptotic process | The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form. |
| neuron differentiation | The process in which a relatively unspecialized cell acquires specialized features of a neuron. |
| positive regulation of neuron apoptotic process | Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. |
| protein targeting to mitochondrion | The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. |
| regulation of phosphoprotein phosphatase activity | Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein. |
| spermatid development | The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5E9Q7 | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Bos taurus (Bovine) | PR |
| Q5ZIY5 | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform | Gallus gallus (Chicken) | PR |
| Q9Y2T4 | PPP2R2C | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform | Homo sapiens (Human) | PR |
| Q66LE6 | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform | Homo sapiens (Human) | PR |
| Q00005 | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Homo sapiens (Human) | PR |
| Q8BG02 | Ppp2r2c | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform | Mus musculus (Mouse) | PR |
| Q6P1F6 | Ppp2r2a | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform | Mus musculus (Mouse) | PR |
| Q6ZWR4 | Ppp2r2b | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Mus musculus (Mouse) | PR |
| P54614 | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Sus scrofa (Pig) | PR |
| P97888 | Ppp2r2c | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform | Rattus norvegicus (Rat) | PR |
| Q0E2P1 | Os02g0224200 | Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Oryza sativa subsp japonica (Rice) | PR |
| Q38821 | PP2AB1 | Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6DIY3 | ppp2r2d | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q0D2F4 | ppp2r2b | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6NY64 | ppp2r2d | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEEDIDTRKI | NNSFLRDHSY | ATEADIISTV | EFNHTGELLA | TGDKGGRVVI | FQREQESKNQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VHRRGEYNVY | STFQSHEPEF | DYLKSLEIEE | KINKIRWLPQ | QNAAYFLLST | NDKTVKLWKV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SERDKRPEGY | NLKDEEGRLR | DPATITTLRV | PVLRPMDLMV | EATPRRVFAN | AHTYHINSIS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VNSDYETYMS | ADDLRINLWN | FEITNQSFNI | VDIKPANMEE | LTEVITAAEF | HPHHCNTFVY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SSSKGTIRLC | DMRASALCDR | HTKFFEEPED | PSNRSFFSEI | ISSISDVKFS | HSGRYIMTRD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YLTAKVWDLN | MENRPVETYQ | VHDYLRSKLC | SLYENDCIFD | KFECVWNGSD | SVIMTGSYNN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FFRMFDRNTK | RDVTLEASRE | NSKPRAILKP | RKVCVGGKRR | KDEISVDSLD | FSKKILHTAW |
| 430 | 440 | ||||
| HPSENIIAVA | ATNNLYIFQD | KVN |