Q8BG02

PR
Gene name
Ppp2r2c
Protein name
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
Names
PP2A subunit B isoform B55-gamma, PP2A subunit B isoform PR55-gamma, PP2A subunit B isoform R2-gamma, PP2A subunit B isoform gamma
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:269643
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

346-425 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BG02

Entry ID Method Resolution Chain Position Source
AF-Q8BG02-F1 Predicted AlphaFoldDB

17 variants for Q8BG02

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388755186 38 L>Q No EVA
rs3388758732 54 E>D No EVA
rs236693821 146 T>K No EVA
rs3388762668 159 M>K No EVA
rs3388742915 175 H>P No EVA
rs3388740006 177 N>H No EVA
rs3388730413 180 S>T No EVA
rs3388752194 230 F>S No EVA
rs3388763972 237 L>P No EVA
rs3388763962 255 A>G No EVA
rs3388754112 281 I>F No EVA
rs3412946430 292 S>T No EVA
rs3388762657 306 V>A No EVA
rs3388742868 317 E>* No EVA
rs3388747299 347 N>T No EVA
rs3388762644 418 T>M No EVA
rs3388763894 432 T>I No EVA

No associated diseases with Q8BG02

8 regional properties for Q8BG02

Type Name Position InterPro Accession
repeat WD40 repeat 13 - 52 IPR001680-1
repeat WD40 repeat 79 - 119 IPR001680-2
repeat WD40 repeat 161 - 200 IPR001680-3
repeat WD40 repeat 211 - 251 IPR001680-4
repeat WD40 repeat 270 - 308 IPR001680-5
repeat WD40 repeat 402 - 439 IPR001680-6
conserved_site Protein phosphatase 2A regulatory subunit PR55, conserved site 79 - 93 IPR018067-1
conserved_site Protein phosphatase 2A regulatory subunit PR55, conserved site 170 - 184 IPR018067-2

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit.

1 GO annotations of molecular function

Name Definition
protein phosphatase regulator activity Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5E9Q7 PPP2R2B Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Bos taurus (Bovine) PR
Q5ZIY5 PPP2R2D Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform Gallus gallus (Chicken) PR
Q00005 PPP2R2B Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Homo sapiens (Human) PR
Q66LE6 PPP2R2D Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform Homo sapiens (Human) PR
Q9Y2T4 PPP2R2C Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform Homo sapiens (Human) PR
Q6P1F6 Ppp2r2a Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform Mus musculus (Mouse) PR
Q6ZWR4 Ppp2r2b Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Mus musculus (Mouse) PR
P54614 PPP2R2B Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Sus scrofa (Pig) PR
P36877 Ppp2r2b Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Rattus norvegicus (Rat) PR
P97888 Ppp2r2c Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform Rattus norvegicus (Rat) PR
Q0E2P1 Os02g0224200 Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Oryza sativa subsp japonica (Rice) PR
Q38821 PP2AB1 Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform Arabidopsis thaliana (Mouse-ear cress) PR
Q0D2F4 ppp2r2b Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6DIY3 ppp2r2d Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6NY64 ppp2r2d Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MGEDTDTRKI NHSFLRDHSY VTEADVISTV EFNHTGELLA TGDKGGRVVI FQREPESKNA
70 80 90 100 110 120
PHSQGEYDVY STFQSHEPEF DYLKSLEIEE KINKIKWLPQ QNAAHSLLST NDKTIKLWKI
130 140 150 160 170 180
TERDKRPEGY NLKDEEGKLK DLSTVTSLQV PVLKPMDLMV EVSPRRTFAN GHTYHINSIS
190 200 210 220 230 240
VNSDCETYMS ADDLRINLWH LAITDRSFNI VDIKPANMED LTEVITASEF HPHHCNLFVY
250 260 270 280 290 300
SSSKGSLRLC DMRAAALCDK HSKLFEEPED PSNRSFFSEI ISSVSDVKFS HSGRYMLTRD
310 320 330 340 350 360
YLTVKVWDLN MEARPIETYQ VHDYLRSKLC SLYESDCIFD KFECAWNGSD SVIMTGAYNN
370 380 390 400 410 420
FFRMFDRNTK RDVTLEASRE SSKPRAVLKP RRVCVGGKRR RDDISVDSLD FTKKILHTAW
430 440
HPAENIIAIA ATNNLYIFQD KVNSDMH