Q6ZWR4

PR
Gene name
Ppp2r2b
Protein name
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Names
PP2A subunit B isoform B55-beta, PP2A subunit B isoform PR55-beta, PP2A subunit B isoform R2-beta, PP2A subunit B isoform beta
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:72930
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

25-102 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6ZWR4

Entry ID Method Resolution Chain Position Source
AF-Q6ZWR4-F1 Predicted AlphaFoldDB

25 variants for Q6ZWR4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389501514 6 D>Y No EVA
rs3389509946 7 T>I No EVA
rs3389512180 15 L>P No EVA
rs3389512236 25 D>V No EVA
rs3389503766 35 T>M No EVA
rs3389512179 41 T>M No EVA
rs3389459115 69 V>I No EVA
rs3389459142 87 E>G No EVA
rs3389517003 107 L>F No EVA
rs3407499487 116 K>E No EVA
rs3389501515 164 P>S No EVA
rs3389512169 180 S>Y No EVA
rs3389500635 181 V>F No EVA
rs3389500319 183 S>N No EVA
rs3408458769 187 T>A No EVA
rs3408652089 187 T>I No EVA
rs3408846581 263 K>* No EVA
rs3408379747 263 K>R No EVA
rs3389479113 295 Y>H No EVA
rs3389410528 343 E>V No EVA
rs3389501529 344 C>* No EVA
rs3389494867 345 V>G No EVA
rs3389509989 346 W>G No EVA
rs3408482558 372 D>V No EVA
rs3389500342 430 A>V No EVA

No associated diseases with Q6ZWR4

8 regional properties for Q6ZWR4

Type Name Position InterPro Accession
repeat WD40 repeat 13 - 52 IPR001680-1
repeat WD40 repeat 79 - 119 IPR001680-2
repeat WD40 repeat 161 - 200 IPR001680-3
repeat WD40 repeat 211 - 251 IPR001680-4
repeat WD40 repeat 270 - 308 IPR001680-5
repeat WD40 repeat 402 - 439 IPR001680-6
conserved_site Protein phosphatase 2A regulatory subunit PR55, conserved site 79 - 93 IPR018067-1
conserved_site Protein phosphatase 2A regulatory subunit PR55, conserved site 170 - 184 IPR018067-2

Functions

Description
EC Number
Subcellular Localization
  • [Isoform 1]: Cytoplasm
  • Cytoplasm, cytoskeleton
  • Membrane
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit.

2 GO annotations of molecular function

Name Definition
protein phosphatase regulator activity Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.
protein-containing complex binding Binding to a macromolecular complex.

5 GO annotations of biological process

Name Definition
mitochondrial fission The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
mitochondrial fragmentation involved in apoptotic process The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form.
positive regulation of neuron apoptotic process Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
protein targeting to mitochondrion The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein.
regulation of phosphoprotein phosphatase activity Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5E9Q7 PPP2R2B Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Bos taurus (Bovine) PR
Q5ZIY5 PPP2R2D Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform Gallus gallus (Chicken) PR
Q66LE6 PPP2R2D Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform Homo sapiens (Human) PR
Q9Y2T4 PPP2R2C Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform Homo sapiens (Human) PR
Q00005 PPP2R2B Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Homo sapiens (Human) PR
Q6P1F6 Ppp2r2a Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform Mus musculus (Mouse) PR
Q8BG02 Ppp2r2c Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform Mus musculus (Mouse) PR
P54614 PPP2R2B Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Sus scrofa (Pig) PR
P97888 Ppp2r2c Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform Rattus norvegicus (Rat) PR
P36877 Ppp2r2b Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Rattus norvegicus (Rat) PR
Q0E2P1 Os02g0224200 Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Oryza sativa subsp japonica (Rice) PR
Q38821 PP2AB1 Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform Arabidopsis thaliana (Mouse-ear cress) PR
Q6DIY3 ppp2r2d Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q0D2F4 ppp2r2b Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6NY64 ppp2r2d Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MEEDIDTRKI NNSFLRDHSY ATEADIISTV EFNHTGELLA TGDKGGRVVI FQREQESKNQ
70 80 90 100 110 120
VHRRGEYNVY STFQSHEPEF DYLKSLEIEE KINKIRWLPQ QNAAYFLLST NDKTVKLWKV
130 140 150 160 170 180
SERDKRPEGY NLKDEEGRLR DPATITTLRV PVLRPMDLMV EATPRRVFAN AHTYHINSIS
190 200 210 220 230 240
VNSDYETYMS ADDLRINLWN FEITNQSFNI VDIKPANMEE LTEVITAAEF HPHHCNTFVY
250 260 270 280 290 300
SSSKGTIRLC DMRASALCDR HTKFFEEPED PSNRSFFSEI ISSISDVKFS HSGRYIMTRD
310 320 330 340 350 360
YLTVKVWDLN MENRPIETYQ VHDYLRSKLC SLYENDCIFD KFECVWNGSD SVIMTGSYNN
370 380 390 400 410 420
FFRMFDRNTK RDVTLEASRE NSKPRAILKP RKVCVGGKRR KDEISVDSLD FSKKILHTAW
430 440
HPSENIIAVA ATNNLYIFQD KVN