Q6DIY3
PR
Gene name |
ppp2r2d |
Protein name |
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform |
Names |
PP2A subunit B isoform B55-delta, PP2A subunit B isoform PR55-delta, PP2A subunit B isoform R2-delta, PP2A subunit B isoform delta |
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:448324 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6DIY3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6DIY3-F1 | Predicted | AlphaFoldDB |
No variants for Q6DIY3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6DIY3 | |||||
No associated diseases with Q6DIY3
9 regional properties for Q6DIY3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 14 - 56 | IPR001680-1 |
| repeat | WD40 repeat | 83 - 123 | IPR001680-2 |
| repeat | WD40 repeat | 165 - 204 | IPR001680-3 |
| repeat | WD40 repeat | 215 - 255 | IPR001680-4 |
| repeat | WD40 repeat | 274 - 312 | IPR001680-5 |
| repeat | WD40 repeat | 339 - 370 | IPR001680-6 |
| repeat | WD40 repeat | 406 - 443 | IPR001680-7 |
| conserved_site | Protein phosphatase 2A regulatory subunit PR55, conserved site | 83 - 97 | IPR018067-1 |
| conserved_site | Protein phosphatase 2A regulatory subunit PR55, conserved site | 174 - 188 | IPR018067-2 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| protein phosphatase type 2A complex | A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein phosphatase regulator activity | Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| exit from mitosis | The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. |
| mitotic cell cycle | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5E9Q7 | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Bos taurus (Bovine) | PR |
| Q5ZIY5 | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform | Gallus gallus (Chicken) | PR |
| Q9Y2T4 | PPP2R2C | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform | Homo sapiens (Human) | PR |
| Q00005 | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Homo sapiens (Human) | PR |
| Q66LE6 | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform | Homo sapiens (Human) | PR |
| Q6ZWR4 | Ppp2r2b | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Mus musculus (Mouse) | PR |
| Q8BG02 | Ppp2r2c | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform | Mus musculus (Mouse) | PR |
| Q6P1F6 | Ppp2r2a | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform | Mus musculus (Mouse) | PR |
| P54614 | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Sus scrofa (Pig) | PR |
| P97888 | Ppp2r2c | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform | Rattus norvegicus (Rat) | PR |
| P36877 | Ppp2r2b | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Rattus norvegicus (Rat) | PR |
| Q0E2P1 | Os02g0224200 | Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Oryza sativa subsp japonica (Rice) | PR |
| Q38821 | PP2AB1 | Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0D2F4 | ppp2r2b | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6NY64 | ppp2r2d | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGVGGGNDF | QWCFSQVKGA | IDEDVAEADI | ISTVEFNCSG | DLLATGDKGG | RVVIFQREQE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NKSRPHSRGE | YNVYSTFQSH | EPEFDYLKSL | EIEEKINKIR | WLPQQNAAHF | LLSTNDKTIK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LWKISERDKR | VEGYNLKDDD | GRLRDPFRIT | SLRVPILKPM | DLMVEASPRR | IFANAHTYHI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NSISVNSDHE | TYLSADDLRI | NLWHLEITDR | SFNIVDIKPA | NMEELTEVIT | AAEFHPHHCN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VFVYSSSKGT | IRLCDMRDSA | LCDRHSKFFE | EPEDPSSRSF | FSEIISSISD | VKFSNSGRYM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MTRDYLSVKV | WDLNMESRPV | ETYQVHEYLR | SKLCSLYEND | CIFDKFECCW | NGSDSAIMTG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SYNNFFRMFD | RNTRRDITLE | ASRESSKPRA | ILKPRKVCTG | GKRKKDEINV | DSLDFNKKIL |
| 430 | 440 | ||||
| HTAWHPTDNI | IAVAATNNLY | IFQDKVN |