Q9XIK4

PR
Gene name
At1g10490 (T10O24.10)
Protein name
RNA cytidine acetyltransferase 1
Names
18S rRNA cytosine acetyltransferase 1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G10490
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

965-1028 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9XIK4

Entry ID Method Resolution Chain Position Source
AF-Q9XIK4-F1 Predicted AlphaFoldDB

60 variants for Q9XIK4

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH04549955 17 V>A No 1000Genomes
tmp_1_3453813_C_T 46 S>L No 1000Genomes
tmp_1_3453861_T_C 62 L>P No 1000Genomes
tmp_1_3454114_C_T 67 H>Y No 1000Genomes
ENSVATH10912621 91 A>P No 1000Genomes
ENSVATH01032406 119 I>M No 1000Genomes
ENSVATH04549964 122 L>I No 1000Genomes
ENSVATH04549967 143 G>S No 1000Genomes
ENSVATH10912624 153 L>V No 1000Genomes
ENSVATH13875687 157 T>A No 1000Genomes
tmp_1_3454587_G_A 171 R>Q No 1000Genomes
ENSVATH01032408 179 S>F No 1000Genomes
ENSVATH04549969 197 V>I No 1000Genomes
tmp_1_3454672_G_A 199 M>I No 1000Genomes
ENSVATH10912815 220 T>R No 1000Genomes
ENSVATH04549975 226 A>G No 1000Genomes
ENSVATH04549976 231 E>Q No 1000Genomes
ENSVATH04549977 231 E>V No 1000Genomes
ENSVATH04549978 252 N>D No 1000Genomes
tmp_1_3454946_G_T 253 K>N No 1000Genomes
tmp_1_3454952_T_G 255 C>W No 1000Genomes
ENSVATH01032413 270 I>L No 1000Genomes
ENSVATH10912819 325 V>L No 1000Genomes
tmp_1_3455820_T_C 396 V>A No 1000Genomes
tmp_1_3456059_G_A 435 R>Q No 1000Genomes
ENSVATH00016103 436 A>S No 1000Genomes
tmp_1_3456068_T_A 438 V>D No 1000Genomes
ENSVATH13875715 477 L>F No 1000Genomes
ENSVATH00016108 498 Y>F No 1000Genomes
tmp_1_3456838_A_G 501 N>D No 1000Genomes
tmp_1_3457156_G_A 554 D>N No 1000Genomes
tmp_1_3457163_C_G 556 S>C No 1000Genomes
ENSVATH04550019 599 F>Y No 1000Genomes
ENSVATH04550021 626 M>T No 1000Genomes
ENSVATH04550024 632 S>Y No 1000Genomes
ENSVATH04550027 657 E>D No 1000Genomes
tmp_1_3457841_G_C 658 V>L No 1000Genomes
ENSVATH04550033 696 R>Q No 1000Genomes
tmp_1_3458106_T_G 720 H>Q No 1000Genomes
ENSVATH04550038 789 K>N No 1000Genomes
ENSVATH10913249 792 M>I No 1000Genomes
ENSVATH01032423 804 V>I No 1000Genomes
ENSVATH10913252 808 G>E No 1000Genomes
ENSVATH10913253 817 K>T No 1000Genomes
tmp_1_3458738_A_T 825 Y>F No 1000Genomes
ENSVATH13875719 862 S>L No 1000Genomes
ENSVATH04550046 866 V>I No 1000Genomes
ENSVATH10913358 902 V>A No 1000Genomes
tmp_1_3459326_G_A 912 G>E No 1000Genomes
ENSVATH10913359 914 A>T No 1000Genomes
tmp_1_3459346_G_A 919 E>K No 1000Genomes
ENSVATH10913362 949 E>K No 1000Genomes
ENSVATH04550061 972 D>E No 1000Genomes
tmp_1_3459762_C_G 975 A>G No 1000Genomes
tmp_1_3459801_T_A 988 L>H No 1000Genomes
tmp_1_3459814_G_C 992 E>D No 1000Genomes
tmp_1_3459877_A_T 1013 R>S No 1000Genomes
tmp_1_3459878_G_A 1014 G>S No 1000Genomes
tmp_1_3459889_G_C 1017 K>N No 1000Genomes
ENSVATH00016116 1021 T>R No 1000Genomes

No associated diseases with Q9XIK4

4 regional properties for Q9XIK4

Type Name Position InterPro Accession
domain GNAT domain 518 - 746 IPR000182
domain Helicase domain 281 - 478 IPR007807
domain tRNA(Met) cytidine acetyltransferase TmcA, N-terminal 8 - 200 IPR013562
domain Possible tRNA binding domain 763 - 977 IPR027992

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
rRNA cytidine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA.
tRNA binding Binding to a transfer RNA.

2 GO annotations of biological process

Name Definition
rRNA acetylation involved in maturation of SSU-rRNA Any rRNA acetylation that is involved in maturation of SSU-rRNA.
tRNA acetylation The modification of tRNA structure by addition of an acetyl group to tRNA. An acetyl group is CH3CO-, derived from acetic

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P53914 KRE33 RNA cytidine acetyltransferase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9H0A0 NAT10 RNA cytidine acetyltransferase Homo sapiens (Human) PR
Q8K224 Nat10 RNA cytidine acetyltransferase Mus musculus (Mouse) PR
O01757 nath-10 RNA cytidine acetyltransferase Caenorhabditis elegans PR
Q9M2Q4 At3g57940 RNA cytidine acetyltransferase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MRKKVDERIR TLIENGVKLR HRSMFVIIGD KARDQIVNLH HILSKSVVKS NPSVLWCYKN
70 80 90 100 110 120
RLDISSHNKK RAKQLKKMKE RGQLDPEKLD AFSLFLDVVD VTHCLYKDSE RILGNTFGIC
130 140 150 160 170 180
ILQDFEALTP NLLARTIETV EGGGLVVLLL QSLASLTSLC TMVMDVHDRF RTESHSEASG
190 200 210 220 230 240
RFNERFLLSL ASCKACVVMD DELNLLPLSS HIKSITKVPT KEDSEALSEA ERDLKSLKDA
250 260 270 280 290 300
LNDDFPVGPL INKCCTLDQG KAVVTFFDAI LDKTLRSIVA LIASRGRGKS AALGLAVAGA
310 320 330 340 350 360
VAAGYSNIYV TAPSPDNLKT VFEFVCKGFD ALEYKEHLEY DVVRSVNPEF NKAIVRINIF
370 380 390 400 410 420
KQHRQTIQYI QPHEHEKLSQ VELLVIDEAA AIPLPVVKSL LGPYLVFLSS TVSGYEGTGR
430 440 450 460 470 480
SLSLKLLQQL EEQSRAPVTG VEGSLSGCLF KKIELSESIR YASGDPIESW LNGLLCLDVA
490 500 510 520 530 540
NCLPNPACHP LPSQCDLYYV NRDTLFSYHK DSELFLQRMM ALCVSSHYKN SPNDLQLLSD
550 560 570 580 590 600
APAHHLFVLL GPVDESKNQL PDILCVIQVC LEGQISRKSA EKSLREGHSP HGDQIPWKFC
610 620 630 640 650 660
EQFRDVVFPK LSGARIVRIA VHPNAMKMGY GSAAVELLTR YFEGQLASIS EGDDELEVEP
670 680 690 700 710 720
SPVRVTEAAA KVSLLEEQIK PRANLPPLLV PLRDRRPERL HYIGVSFGLT LDLFRFWRKH
730 740 750 760 770 780
KFAPFYISQI PSAVTGEHTC MLLKPLTLSN DEFEVDESDE LGFFAPFYKD FRIRFSKLLS
790 800 810 820 830 840
DKFKKMDYKL AMSVLNPKIN FPEVDLTGNS PDGFLKKLDG VLSPYDMERF RAYTANLVDF
850 860 870 880 890 900
NLVYDICKTL AHHYFQEKLP VSLSYVQASV LLCLGLQESD FSSIERQMQL ERGQIYSLLL
910 920 930 940 950 960
KVGKKLYKYL NGIATKELES TLPRLKDRVL EPHKVSVDED LREGAKEVEE QMRARIEELL
970 980 990 1000 1010 1020
DPELLDQFAI GDKEAEALQK SKISSSGLIS IESTKTDNKK EKPSGFDKSA KKRGNDKHSS
TSNKKRRA