O01757

PR
Gene name
nath-10
Protein name
RNA cytidine acetyltransferase
Names
18S rRNA cytosine acetyltransferase
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_F55A12.8
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

986-1043 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O01757

Entry ID Method Resolution Chain Position Source
AF-O01757-F1 Predicted AlphaFoldDB

No variants for O01757

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O01757

No associated diseases with O01757

4 regional properties for O01757

Type Name Position InterPro Accession
domain GNAT domain 521 - 750 IPR000182
domain Helicase domain 280 - 480 IPR007807
domain tRNA(Met) cytidine acetyltransferase TmcA, N-terminal 8 - 200 IPR013562
domain Possible tRNA binding domain 765 - 994 IPR027992

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
rRNA cytidine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA.
tRNA binding Binding to a transfer RNA.

2 GO annotations of biological process

Name Definition
rRNA acetylation involved in maturation of SSU-rRNA Any rRNA acetylation that is involved in maturation of SSU-rRNA.
tRNA acetylation The modification of tRNA structure by addition of an acetyl group to tRNA. An acetyl group is CH3CO-, derived from acetic

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P53914 KRE33 RNA cytidine acetyltransferase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9H0A0 NAT10 RNA cytidine acetyltransferase Homo sapiens (Human) PR
Q8K224 Nat10 RNA cytidine acetyltransferase Mus musculus (Mouse) PR
Q9XIK4 At1g10490 RNA cytidine acetyltransferase 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M2Q4 At3g57940 RNA cytidine acetyltransferase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MRTKLDGRIR TQIENGVASG HRSMFAVVGD KARDQVPILY HILSKSTVSA RPNVLWCYKK
70 80 90 100 110 120
ELSFSTHRAK KAKKMKKATT TISGSLPDAD PFDVFISSTQ IRYCYYNETE KILGNTFGVL
130 140 150 160 170 180
VLQDFEAMTP NLLARTIETI EGGGMVILLM QSVRSLRQLY TISMDVHNRY RTEAHNEITA
190 200 210 220 230 240
RFNERFILSL ASCSSVLVLD DQLRVLPISS HIENVEAIPA SQKKIQSESD AELASLKEAM
250 260 270 280 290 300
KETKPIGPLL SRARTACQAK ALLRFLDVIT EKQSNVTCSL TAGRGRGKSA AVGLSLAGAI
310 320 330 340 350 360
AFGYTNIFVT SPSPENLKTL FEFVVKGFDA LDYQEHTDYE LIQSANPEFK NCLVRINVFR
370 380 390 400 410 420
EHKQTIQYIS PTDVQKLGQC ELIVIDEAAA IPLPLVKELI SGPYISFLSS TINGYEGTGR
430 440 450 460 470 480
SLSLKLLQQL RQQSAGGEAK EGKSASNKGK TLHEMHMEES IRYKPGDKIE KWLNRLLCLD
490 500 510 520 530 540
ATNCQLKLEC GTPPPAACEL YIVNRDTLFS FHDASEAFLQ QVMAIFVSAH YKNSPNDLQM
550 560 570 580 590 600
LSDAPAHNLF VLMAPIDKSR KTIPEVLAVV QVCLEGRLDS DNIQNGLESG KRAAGDLLPW
610 620 630 640 650 660
TVSQQFMDKQ FGTLCGGRIV RVAVHPDYQS MGYGGRAVQL IEQYYLGLAT SLDEEEKAPA
670 680 690 700 710 720
PPSKTVIKQV KDGHTVELLE ERIEPRADLP PLLQRLDERK PERLDYLGVS FGLTVPLLKF
730 740 750 760 770 780
WKRNEFVPVY IRQNSNDITG EHTCIILKGL EHGGSDSDEE PSATWLPVYW REFRRRIVNL
790 800 810 820 830 840
LSFDFSSFPA QMALSLLQLK NKHVEKQMKR LVIERSELAI HLSNTDLRRM SQYGRNMVDS
850 860 870 880 890 900
HIITDILPIV AKLNFEQRLP QELKLAVTQS AILLARGLQH KHFEDISKEL DLPMNQIFAL
910 920 930 940 950 960
LTKAIRRIGD WFDEVCETAV RENLDKEAEA SAANKPTSSL PKAVPLANLE DELESAAKEI
970 980 990 1000 1010 1020
RARHDRDRKA LLAELGNELQ KYEIIQDEKE LAEAYESVNM KYANKLVSVK SKRTAIQAAI
1030 1040
PDAKDPANKN AKKKKRFSSG GRR