P53914

PR
Gene name
KRE33
Protein name
RNA cytidine acetyltransferase
Names
18S rRNA cytosine acetyltransferase, Killer toxin-resistance protein 33, Ribosomal RNA cytidine acetyltransferase 1
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YNL132W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1001-1056 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

13 structures for P53914

Entry ID Method Resolution Chain Position Source
5WLC EM 380 A LX/LY 1-208 PDB
6KE6 EM 340 A RL/RM 1-1056 PDB
6LQP EM 320 A RL/RM 1-1056 PDB
6LQQ EM 410 A RL/RM 1-1056 PDB
6LQR EM 860 A RL/RM 1-1056 PDB
6LQU EM 370 A RL/RM 1-1056 PDB
6LQV EM 480 A RL/RM 1-1056 PDB
6ZQB EM 390 A JA/JB 1-1056 PDB
6ZQC EM 380 A JA/JB 1-1056 PDB
7AJT EM 460 A JA/JB 1-1056 PDB
7D63 EM 1230 A RL/RM 1-1056 PDB
7SUK EM 399 A LX/LY 2-924 PDB
AF-P53914-F1 Predicted AlphaFoldDB

9 variants for P53914

Variant ID(s) Position Change Description Diseaes Association Provenance
s14-375459 46 S>N No SGRP
s14-375483 54 S>F No SGRP
s14-376821 500 P>L No SGRP
s14-377033 571 I>V No SGRP
s14-377384 688 A>T No SGRP
s14-377753 811 A>T No SGRP
s14-377780 820 H>Y No SGRP
s14-377889 856 G>V No SGRP
s14-378012 897 T>I No SGRP

No associated diseases with P53914

4 regional properties for P53914

Type Name Position InterPro Accession
domain GNAT domain 536 - 766 IPR000182
domain Helicase domain 281 - 493 IPR007807
domain tRNA(Met) cytidine acetyltransferase TmcA, N-terminal 9 - 202 IPR013562
domain Possible tRNA binding domain 773 - 1007 IPR027992

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
90S preribosome A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
preribosome, small subunit precursor A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.
small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
rRNA cytidine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA.
snoRNA binding Binding to a small nucleolar RNA.
tRNA binding Binding to a transfer RNA.

5 GO annotations of biological process

Name Definition
maturation of SSU-rRNA Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.
mRNA modification The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically.
ribosomal small subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.
rRNA acetylation involved in maturation of SSU-rRNA Any rRNA acetylation that is involved in maturation of SSU-rRNA.
tRNA acetylation The modification of tRNA structure by addition of an acetyl group to tRNA. An acetyl group is CH3CO-, derived from acetic

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H0A0 NAT10 RNA cytidine acetyltransferase Homo sapiens (Human) PR
Q8K224 Nat10 RNA cytidine acetyltransferase Mus musculus (Mouse) PR
O01757 nath-10 RNA cytidine acetyltransferase Caenorhabditis elegans PR
Q9M2Q4 At3g57940 RNA cytidine acetyltransferase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9XIK4 At1g10490 RNA cytidine acetyltransferase 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAKKAIDSRI PSLIRNGVQT KQRSIFVIVG DRARNQLPNL HYLMMSADLK MNKSVLWAYK
70 80 90 100 110 120
KKLLGFTSHR KKRENKIKKE IKRGTREVNE MDPFESFISN QNIRYVYYKE SEKILGNTYG
130 140 150 160 170 180
MCILQDFEAL TPNLLARTIE TVEGGGIVVI LLKSMSSLKQ LYTMTMDVHA RYRTEAHGDV
190 200 210 220 230 240
VARFNERFIL SLGSNPNCLV VDDELNVLPL SGAKNVKPLP PKEDDELPPK QLELQELKES
250 260 270 280 290 300
LEDVQPAGSL VSLSKTVNQA HAILSFIDAI SEKTLNFTVA LTAGRGRGKS AALGISIAAA
310 320 330 340 350 360
VSHGYSNIFV TSPSPENLKT LFEFIFKGFD ALGYQEHIDY DIIQSTNPDF NKAIVRVDIK
370 380 390 400 410 420
RDHRQTIQYI VPQDHQVLGQ AELVVIDEAA AIPLPIVKNL LGPYLVFMAS TINGYEGTGR
430 440 450 460 470 480
SLSLKLIQQL RNQNNTSGRE STQTAVVSRD NKEKDSHLHS QSRQLREISL DEPIRYAPGD
490 500 510 520 530 540
PIEKWLNKLL CLDVTLIKNP RFATRGTPHP SQCNLFVVNR DTLFSYHPVS ENFLEKMMAL
550 560 570 580 590 600
YVSSHYKNSP NDLQLMSDAP AHKLFVLLPP IDPKDGGRIP DPLCVIQIAL EGEISKESVR
610 620 630 640 650 660
NSLSRGQRAG GDLIPWLISQ QFQDEEFASL SGARIVRIAT NPEYASMGYG SRAIELLRDY
670 680 690 700 710 720
FEGKFTDMSE DVRPKDYSIK RVSDKELAKT NLLKDDVKLR DAKTLPPLLL KLSEQPPHYL
730 740 750 760 770 780
HYLGVSYGLT QSLHKFWKNN SFVPVYLRQT ANDLTGEHTC VMLNVLEGRE SNWLVEFAKD
790 800 810 820 830 840
FRKRFLSLLS YDFHKFTAVQ ALSVIESSKK AQDLSDDEKH DNKELTRTHL DDIFSPFDLK
850 860 870 880 890 900
RLDSYSNNLL DYHVIGDMIP MLALLYFGDK MGDSVKLSSV QSAILLAIGL QRKNIDTIAK
910 920 930 940 950 960
ELNLPSNQTI AMFAKIMRKM SQYFRQLLSQ SIEETLPNIK DDAIAEMDGE EIKNYNAAEA
970 980 990 1000 1010 1020
LDQMEEDLEE AGSEAVQAMR EKQKELINSL NLDKYAINDN SEEWAESQKS LEIAAKAKGV
1030 1040 1050
VSLKTGKKRT TEKAEDIYRQ EMKAMKKPRK SKKAAN